Progressive degeneration in the cochlear nucleus after chemical destruction of the cochlea.

Abstract:

:In the guinea pig, the organ of Corti and the spiral ganglion cells were destroyed by administering gentamicin into the inner ear. The antero-ventral cochlear nucleus (AVCN) was studied with electron microscopy 15 and 30 days after treatment. There does not seem to be a specific type of degeneration induced by the drug. For nerve terminals, a progressive degeneration occurred: after 15 days, clear and swollen boutons appeared and after 30 days an electron-dense type of degeneration was observed. The cell bodies of the AVCN did not seem altered infirming a rapid, direct or indirect, neurotoxic effect of the drug.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Koitchev K,Aran JM,Ivanov E,Cazals Y

doi

10.3109/00016488609108643

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

31-9

issue

1-2

eissn

0001-6489

issn

1651-2251

journal_volume

102

pub_type

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