Freeze-fracturing of vestibular sensory epithelia in a strain of the waltzing guinea pig.

Abstract:

:The waltzing guinea pig exhibits genetically induced inner ear disease which develops into deafness and vestibular disorder. The type I hair cell in vestibular end organs shows specific pathology, featuring protrusion of the hair cell apex, sensory hair fusion and an intracellular actin filament rod. With the freeze-fracturing technique, consecutive stages of degeneration of the apical part of the type I hair cell are shown. Different possible mechanisms underlying these changes are discussed. It is probable that the genetically induced prenatally developed hair cell pathology is related to a pathological development of actin filaments and their connections in the apical cytoskeleton.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Sobin A,Flock A,Bagger-Sjöbäck D

doi

10.3109/00016488309132893

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

207-14

issue

3-4

eissn

0001-6489

issn

1651-2251

journal_volume

96

pub_type

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