Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy.

Abstract:

CONCLUSION:Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of many sarcomas, PDT appears to be an organ- and function-sparing therapy, although it is more costly than other treatments. OBJECTIVES:The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer. METHODS:We studied the results of PDT when used as a primary treatment. We looked at survival, effect on tumor, side effects, voice, and costs. RESULTS:The follow-up period was a median of 59 months. Nine of 10 patients were cured of their laryngeal cancer. PDT alone cured seven patients. All four of the sarcomas were cured using temoporfin. Two of three tumors that involved the anterior commissure were cured using only interstitial illumination with PDT. No serious side effects were noted. The patient's voices were improved after treatment in 5 of 10 cases, and none had a worsened voice.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

von Beckerath MP,Reizenstein JA,Berner AL,Nordqvist KW,Landström FJ,Löfgren AL,Möller CG

doi

10.3109/00016489.2014.906748

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

852-8

issue

8

eissn

0001-6489

issn

1651-2251

journal_volume

134

pub_type

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