Quinine-induced hearing loss in the guinea pig is not affected by the Ca2+ channel antagonist verapamil.

Abstract:

:It is well documented that quinine induces reversible hearing loss and tinnitus. The purpose in this study was to induce a quinine hearing loss and to investigate if verapamil, a Ca2+ channel antagonist of L-type might affect the response. Pigmented guinea pigs (n = 24) were anaesthetized by atropine. Hypnorm and midazolam but permitting spontaneous respiration. An electrode of platinum was placed on the round window and short (10 msec) tone pulses at 8 kHz were presented to the external ear. A typical deflection of the N1-wave was determined as the hearing threshold. Quinine hydrochloride 40 mg/kg and verapamil 1 mg/kg were given intravenously. Quinine induced a significant and reversible hearing loss (mean 16 dB). This hearing loss was not at all affected by verapamil given before or after quinine. Verapamil often caused acute cardiac arrest and particularly the combination verapamil followed by quinine-induced death to the animal. We conclude that verapamil and quinine had no in vivo interaction with regard to the hearing ability.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Jäger W,Idrizbegovic E,Karlsson KK,Alván G

doi

10.3109/00016489709117990

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

46-8

issue

1

eissn

0001-6489

issn

1651-2251

journal_volume

117

pub_type

杂志文章
  • Spindle cell carcinoma of the larynx.

    abstract::Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. The histogenesis of spindle cell tumours has been much debated, but electron microscopic investigations have shown that most of the laryngeal lesions are squamous epithelial carcinomas that have undergone tra...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409107550

    authors: Katholm M,Krogdahl A,Hainau B,Bretlau P

    更新日期:1984-07-01 00:00:00

  • Compound action potential and cochlear microphonic extracted from electrocochleographic responses to condensation or rarefaction clicks.

    abstract::In electrocochleography (ECochG) compound action potential (CAP) and summation potential (SP) are usually separated from the cochlear microphonic (CM) by the CM cancellation technique consisting in averaging the responses evoked by rarefaction and condensation clicks. With the aim of analysing the ECochG responses evo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/000164800750000892

    authors: Arslan E,Santarelli R,Sparacino G,Sella G

    更新日期:2000-03-01 00:00:00

  • Lateralization of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) with the latency test: a pilot study.

    abstract::Background: The treatments of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) have low remission rates ranging between 60% and 90%, connected to the difficulty in correctly identifying the affected side of HSC-BPPV. Objective: To propose and compare the efficacy of the latency test (LT) i...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1635712

    authors: Scarpa A,Cassandro C,Gioacchini FM,Viola P,Cuofano R,Kaleci S,Ralli M,Chiarella G,Cassandro E

    更新日期:2019-10-01 00:00:00

  • Increased levels of urokinase receptor in plasma of head and neck squamous cell carcinoma patients.

    abstract::Urokinase-type plasminogen activator (uPA) is important for matrix degradation and motility of cancer cells. The binding of uPA to its cell surface receptor on cancer cells is essential for effective invasion. A soluble form of urokinase receptor (suPAR) has been described in serum and ascites of ovarian cancer patien...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950180342

    authors: Schmidt M,Hoppe F

    更新日期:1999-01-01 00:00:00

  • Evaluation of phenotype of mononuclear host cells isolated from primary tumour and peripheral blood of patients with laryngeal carcinoma.

    abstract::Mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel of monoclonal antibodies against various lymphocyte subsets and macrophages. Tumours of various staging groups were examined in parallel with cells isolated from patient and donor periphe...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809119459

    authors: Zeromski J,Pietrzak J,Szmeja Z,Jezewska E,Górny MK,Kruk-Zagajewska A

    更新日期:1988-01-01 00:00:00

  • Analysis on outcomes of facial paralysis complicated by middle ear cholesteatoma.

    abstract:BACKGROUND:The prognostic factors of facial paralysis complicated by middle ear cholesteatoma (MEC) are largely unknown due to limited reports and smaller sample size. OBJECTIVES:This study aimed to analyze prognostic factors of postoperative outcomes of facial paralysis complicated by MEC. MATERIAL AND METHODS:Clini...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1543951

    authors: Li Q,Jia Y,Feng Q,Tang B,Luo X,Xu P,Wang D,Zhang X

    更新日期:2019-02-01 00:00:00

  • Speech-reception Threshold in Noise for Hearing-impaired Listeners in Conditions with a Varying Amplitude-Frequency Response.

    abstract::In a study on the effects of a frequency-dependent automatic gain control in hearing-aids, two experiments were carried out with hearing-impaired listeners. In the first experiment, the effect of varying the amplitude-frequency response on the speech-reception threshold (SRT) of sentences presented in noise was studie...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.1990.12088430

    authors: Van Dijkhuizen JN,Festen JM,Plomp R

    更新日期:1990-01-01 00:00:00

  • MicroRNA-21 promotes the proliferation and invasion of cholesteatoma keratinocytes.

    abstract:CONCLUSIONS:The present study revealed that miR-21 promotes the proliferation and invasion of cholesteatoma keratinocytes. These results provide a partial explanation for the more aggressive clinical behavior observed in cholesteatoma. OBJECTIVE:This study aims to investigate the post-transcriptional regulatory effect...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1202447

    authors: Chen X,Li X,Qin Z

    更新日期:2016-12-01 00:00:00

  • Nasal peak flow rate records in work related nasal blockage.

    abstract::Eleven patients, who had symptoms of blocking nose in relation to exposure to airway irritants in their work environment, and 11 control subjects recorded nasal and bronchial peak expiratory flow rates (PEFRN and PEFRB) during a working week. In contrast to the control subjects the patients demonstrated a pattern of g...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Ahman M

    更新日期:1992-09-01 00:00:00

  • Outcome of surgical management of laryngeal carcinoma: a 5-year experience.

    abstract:OBJECTIVE:To investigate the outcome of surgically managed laryngeal carcinoma patients attending an outpatient clinic over a 5-year period. MATERIAL AND METHODS:This was an analytical, retrospective, cross-sectional study. A total of 36 laryngeal carcinoma patients who were managed surgically with or without radiothe...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410018070

    authors: Baskota DK,Prasad R,Sinha BK,Amatya RC,Bhattarai H,Guragain RP

    更新日期:2004-08-01 00:00:00

  • Impaired membrane targeting and aberrant cellular localization of human Cx26 mutants associated with inherited recessive hearing loss.

    abstract:CONCLUSION:This study demonstrated that five Cx26 mutations (R32H, S199F, 572delT, 631-632delGT, and Y155X) affect gap junction (GJ) functions by causing impaired membrane targeting and aberrant cellular localization, and one mutation (R165W) leads to a constriction of the channel pore with no dye coupling. OBJECTIVE:...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.506885

    authors: Xiao Z,Yang Z,Liu X,Xie D

    更新日期:2011-01-01 00:00:00

  • The effect of maxillary sinus surgery on its development.

    abstract:CONCLUSION:The study showed that surgery in the maxillary sinus can affect its development. OBJECTIVE:To quantitatively evaluate the long-term impact of sinus surgery on its development in the rabbit. MATERIALS AND METHODS:This was an experimental study performed at an academic tertiary medical center using 20 4-week...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701596039

    authors: Bahadir O,Bahadir A,Kosucu P,Livaoglu M

    更新日期:2008-05-01 00:00:00

  • Activated T cells and Leu-7+ cells in Bell's palsy.

    abstract::Patients with Bell's palsy were investigated with regard to the cellular immune response during the acute and convalescent stages with the purpose of acquiring information concerning the etiology of the condition. In order to ascertain whether there was activation of the immune system, the proportion of activated T ce...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809119452

    authors: Jonsson L,Sjöberg O,Thomander L

    更新日期:1988-01-01 00:00:00

  • Heavy metal staining, a comparative assessment of gadolinium chloride and osmium tetroxide for inner ear labyrinthine contrast enhancement using X-ray microtomography.

    abstract:CONCLUSION:The use of both gadolinium chloride (GdCl(3)) and osmium tetroxide (OsO(4)) allowed for the visualization of the membranous labyrinth and other intralabyrinthine structures, at different intensities, as compared with the control sample. This initial comparison shows the advantages of GdCl(3) in radiological ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.715751

    authors: Wong CC,Curthoys IS,O'Leary SJ,Jones AS

    更新日期:2013-01-01 00:00:00

  • One-third of vertiginous episodes during the follow-up period are caused by benign paroxysmal positional vertigo in patients with Meniere's disease.

    abstract:CONCLUSION:In the present study, about one-third of patients with Meniere's disease developed benign paroxysmal positional vertigo (BPPV)-like attacks. Additionally, more than one-third of all vertigo attacks were BPPV-like attacks. Thus, vertigo attacks in patients with Meniere's disease must be carefully treated beca...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.936624

    authors: Taura A,Funabiki K,Ohgita H,Ogino E,Torii H,Matsunaga M,Ito J

    更新日期:2014-11-01 00:00:00

  • The developing electrolytes concentrations of inner ear fluids in guinea pigs.

    abstract::Cochlear endolymph, scala tympani perilymph, and scala vestibuli perilymph were collected from fetal, neonatal, and mature guinea pigs. The concentrations of Na and K in these fluids were then assessed using a microflame photometer. The electrolyte composition in the endolymph was already characterized by a high conce...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509182256

    authors: Kanoh N,Ohmura M,Fukazawa T,Hirono Y,Makimoto K

    更新日期:1985-05-01 00:00:00

  • Otolith function tests in patients with unilateral vestibular lesions.

    abstract::This study was designed to assess the utility of otolith-ocular reflex testing in patients with complete unilateral peripheral vestibular deficits. Ten subjects were given a clinical vestibular test battery (ENG & vertical rotation) and research oriented tests of otolith function including dynamic posturography with h...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139392

    authors: Payman RN,Wall C 3rd,Ash-Bernal R

    更新日期:1995-11-01 00:00:00

  • Clinical profile of hearing loss in children with congenital cytomegalovirus (CMV) infection: CMV DNA diagnosis using preserved umbilical cord.

    abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.583268

    authors: Furutate S,Iwasaki S,Nishio SY,Moteki H,Usami S

    更新日期:2011-09-01 00:00:00

  • The roles of local inhibition mediated by gamma-aminobutyric acid (GABA)-A receptor in duration tuning in the inferior colliculus of guinea pigs.

    abstract:CONCLUSION:GABA-mediated inhibition is responsible for the duration tuning in the inferior colliculus (IC) of guinea pigs, a non-echo-locating mammal. Duration tuning in this species is better demonstrated in an appropriate short time window. OBJECTIVES:To investigate the role of GABA-mediated inhibition in duration t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701840122

    authors: Yin S,Chen Z,Feng Y,Wang J

    更新日期:2008-10-01 00:00:00

  • The association of codeine, macrocytosis and bilateral sudden or rapidly progressive profound sensorineural deafness.

    abstract:CONCLUSIONS:Codeine shows a similar association with profound deafness to other opiates. Good cochlear implant outcomes suggest a sensory disorder. Although macrocytosis could be due to confounding factors, the lack of other consistent findings may signify a vascular pathology. OBJECTIVES:To describe a series of patie...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802579082

    authors: Freeman SR,Bray ME,Amos CS,Gibson WP

    更新日期:2009-10-01 00:00:00

  • Resting potentials in the inner sulcus and tunnel of corti.

    abstract::Under constant visual guidance and closed-circuit television monitoring, electrodes are inserted into the fluid spaces of the organ of Corti. The resting electrical potentials are determined with respect to the neutral voltage of the guinea pig and related to other potentials of the auditory labyrinth. The resting pot...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509124690

    authors: Lawrence M

    更新日期:1975-03-01 00:00:00

  • Intraoperative monitoring of facial nerve antidromic potentials during acoustic neuroma surgery.

    abstract::The present paper presents monopolar recording of facial nerve antidromic potentials as an alternative technique to facial electromyography for the continuous monitoring of the facial nerve during acoustic neuroma surgery. The investigation involved 22 patients undergoing acoustic neuroma surgery via a retrosigmoid ap...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709113457

    authors: Colletti V,Fiorino F,Policante Z,Bruni L

    更新日期:1997-09-01 00:00:00

  • Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis.

    abstract::Abstract Usage of the Vibrant Soundbridge (VSB) with round window (RW)-Coupler placement at the RW has been shown to successfully treat mixed hearing loss. Coupling between the VSB's floating mass transducer (FMT) and the RW membrane is difficult in the case of sclerosis in the RW and drilling down the bony lip unti...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.649492

    authors: Iwasaki S,Suzuki H,Moteki H,Miyagawa M,Takumi Y,Usami S

    更新日期:2012-06-01 00:00:00

  • Human papillomavirus (HPV)-positive tonsillar carcinomas are frequent and have a favourable prognosis in males in Norway.

    abstract:CONCLUSIONS:This study confirms a high prevalence of human papillomavirus (HPV)-positive tonsillar tumours (52%). The survival of the HPV-positive group was significantly better in males. OBJECTIVES:We assessed the prevalence of HPV in 137 patients with tonsillar carcinomas, measured the p53- and Ki-67-positive tumour...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903071377

    authors: Hannisdal K,Schjølberg A,De Angelis PM,Boysen M,Clausen OP

    更新日期:2010-02-01 00:00:00

  • Vestibulo-ocular responses during static head roll and three-dimensional head impulses after vestibular neuritis.

    abstract::This study aimed to investigate whether unilateral vestibular neuritis (VN) causes the same deficits of ocular counter-roll during static head roll (OCR(S)) and dynamic vestibulo-ocular reflex gains during head impulses (VOR(HI)) as unilateral vestibular deafferentation (VD). Ten patients with acute and 14 patients wi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950180379

    authors: Schmid-Priscoveanu A,Straumann D,Böhmer A,Obzina H

    更新日期:1999-01-01 00:00:00

  • Can the bending forward test be used to detect a diseased anterior semi-circular canal in patients with chronic vestibular multi-canalicular canalithiasis (BPPV)?

    abstract::Introduction: Patients with chronic vestibular multi-canalicular canalithiasis (CVMCC) can have serious morbidities, for example, musculoskeletal pain, dizziness, fatigue, and cognitive difficulties. Involvement of the anterior semi-circular canal (SCC) is common in CVMCC. A mono-canalicular diseased anterior SCC is r...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.1080/00016489.2019.1667529

    authors: Iglebekk W,Tjell C,Borenstein P

    更新日期:2019-12-01 00:00:00

  • Circadian rhythm dependent kanamycin-induced hearing loss in rodents assessed by auditory brainstem responses.

    abstract::An antimicrobial agent, kanamycin, has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of kanamycin ototoxicity as a function of Rx timing with regard to circadian rhythms. Four groups of comparable weight Sprague-Dawley rats received a daily ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109100749

    authors: Yonovitz A,Fisch JE

    更新日期:1991-01-01 00:00:00

  • Redistribution of facial nerve motor neurons after recovery from nerve crushing injury in the gerbil.

    abstract::We investigated the redistribution of facial motor neurons after recovery from a crush injury of the facial nerve in the mongolian gerbil, with the retrograde transportation of horseradish peroxidase (HRP) technique. The facial nerve at the vertical segment was crushed unilaterally for 10 s with forceps. After 1 month...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139307

    authors: Park HJ,Kim HN,Kim KM

    更新日期:1995-03-01 00:00:00

  • Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma: immunohistochemical and tissue microarray analysis.

    abstract:CONCLUSION:This work demonstrated that juvenile nasopharyngeal angiofibromas (JNAs) express high levels of hormone receptors and vascular endothelial growth factor (VEGF) compared with normal nasal mucosa. The interaction between hormone receptors and VEGF may be involved in the initiation and growth of JNA. OBJECTIVE...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.952774

    authors: Liu Z,Wang J,Wang H,Wang D,Hu L,Liu Q,Sun X

    更新日期:2015-01-01 00:00:00

  • A contribution to the structural pattern differences between the apical and basal spiral ganglions in mammals.

    abstract::The purpose of this paper was to establish a mammalian comparative study between the neuronal spaces of the upper versus the basal cochlear turns. We studied with light microscopy i) Webster albino rat embryos at various gestational days (GD), and a postnatal (PN) series; ii) kittens 3 weeks old; iii) pigmented guinea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709117781

    authors: Sánchez-Fernández JM,Sánchez-del Rey A,Santaolalla-Montoya F,Martinez Ibarguen A

    更新日期:1997-03-01 00:00:00