Abstract:
:Interleukins 6 (IL-6) and 12 (IL-12), and the chemoattractant chemokine RANTES were studied in ethmoidal mucosa, using reverse transcriptase polymerase chain reaction. The 49 patients had chronic sinusitis or nasal/paranasal polyposis, and some also allergy. To the best of our knowledge, this is the first study that demonstrates RANTES and IL-12 on mRNA level in human sinonasal mucosa in situ. mRNA for IL-6, IL-12 and RANTES were detected in 2, 8 and 6 patients with chronic sinusitis, respectively, and in mucosa from patients with polyposis a positive expression was observed in 4, 14 and 10 cases. There were no statistically significant differences. Analysing the entire group of 49 patients, disregarding type of mucosal disease, the number of patients with positive RANTES was significantly higher than that for IL-6. Similarly, IL-12 positivity was more frequently expressed than IL-6. mRNA for IL-6 was expressed in only 2 of the allergic patients. The cytokine production studied thus seems to be unrelated to the clinically defined entities. There is thus a local production in human diseased sinonasal mucosa of RANTES, as well as of IL-6 and IL-12. The local production of RANTES is an important prerequisite for recruitment and migration of inflammatory cells into the tissue. IL-12 is a co-stimulator of antigen-specific responses of established T helper 1 (Th1) clones, and regulates the responsiveness of the clones to a number of T cell growth factors. The study supports a shift towards Th1 cells in these disease entities.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Davidsson A,Danielsen A,Viale G,Olofsson J,Dell'Orto P,Pellegrini C,Karlsson MG,Hellquist HBdoi
10.3109/00016489609137897subject
Has Abstractpub_date
1996-07-01 00:00:00pages
604-10issue
4eissn
0001-6489issn
1651-2251journal_volume
116pub_type
杂志文章abstract:CONCLUSION:Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16 (HPV16)-related squamous cell carcinoma of the head and neck (HNSCC). OBJECTIVES:To evaluate the effectiveness of siRNA targeting E6 and/or E7 on the in vitro and in vivo growth ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.773405
更新日期:2013-07-01 00:00:00
abstract::Normal subjects were exposed to two kinds of optokinetic stimulation, viz. at speeds of 60 degrees/s and 90 degrees/s preceded by acceleration at 6 degrees/s2 and 4.5 degrees/s2, respectively. In most subjects the speed of the eye in the slow nystagmus phase equalled the speed of the rotating device during the acceler...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709123954
更新日期:1977-09-01 00:00:00
abstract:CONCLUSIONS:A new method for noninvasive standard evaluation of normal endolymphatic space and endolymphatic hydrops using magnetic resonance imaging (MRI) is indicated. OBJECTIVE:To standardize the evaluation of endolymphatic space in the cochlea and the vestibule in healthy volunteers by applying noninvasive intraty...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
doi:10.3109/00016489.2010.524938
更新日期:2011-03-01 00:00:00
abstract:CONCLUSION:PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. OBJECTIVES:Assessment of remission at the primary site, in patients treated with organ preservation ther...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.895038
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To assess paranasal sinus material histopathologically for the presence of fungus. MATERIAL AND METHODS:Paraffin-embedded archival biopsy samples of patients who underwent endonasal sinus surgery between 1992 and 2002 were retrospectively assessed for the presence of fungi. Hematoxylin-eosin-stained sections...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001222
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Multiple patches of atrophy have been reported in the stria vascularis (SV) in elderly persons with presbycusis The aim of this study was to investigate the correlation between sensorineural hearing loss and this strial condition. MATERIALS AND METHODS:We established a new animal model comprising two small l...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0001648021000028131
更新日期:2003-04-01 00:00:00
abstract::To predict the possible benefit of a cochlear implant to a patient, the clinician requires a reliable objective method to monitor the presence of surviving fibres in the 8th nerve. The subjective promontory test and the evaluation of electrically evoked brainstem potentials are not adequate. An electrical stimulus art...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126093
更新日期:1994-09-01 00:00:00
abstract::This study was performed in order to determine the immunohistochemical expression and distribution pattern as well as the electrophysiological actions of substance P in human vestibular ganglion cells. Substance P-like immunostaining was mainly found in the cytoplasm of small vestibular ganglion cells. In contrast, ne...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137839
更新日期:1996-03-01 00:00:00
abstract::Transitory hearing impairment has been well documented in humans during basilar migraine attacks. Ischemia induced by activation of central nervous system adrenoreceptors by cAMP is one of the mechanisms that has been implicated, as well as calcium metabolism alterations. Propranolol-HCl has proven to be an effective ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109137383
更新日期:1991-01-01 00:00:00
abstract::Voluntary control of the human vestibulo-ocular reflex with and without visual targets was investigated. Subjects were rotated sinusoidally from 0.1 to 1.0 Hz using d.c. electro-oculography to record eye position. The ratio of eye to head movement, or gain, of the vestibulo-ocular reflex was measured. When subjects we...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609107490
更新日期:1976-05-01 00:00:00
abstract:CONCLUSIONS:Over-adduction of the unaffected vocal fold may not compensate vocal function in unilateral vocal fold paralysis (UVFP). OBJECTIVE:To determine whether over-adduction of the unaffected vocal fold has any impact on vocal function in patients with UVFP. METHODS:A total of 101 patients with UVFP who underwen...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.886020
更新日期:2014-07-01 00:00:00
abstract::Primary non-Hodgkin's lymphoma of the nasal cavity is a disease more likely to affect men than women; it is characterized by a T cell immunophenotype and is often associated with involvement of the paranasal structures and with high recurrence rates. Many authors report that its extremely poor prognosis depends on tum...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750046081
更新日期:2000-06-01 00:00:00
abstract::In a previous study, the authors described a technique for recording ipsilateral EABRs using the DIGISONIC MXM cochlear implant (Gallégo et al, Acta Otolaryngol (Stockh) 1996; 116: 228-33) and showed that the EABR input/output functions were very similar across electrodes. In the present study a test of electrode func...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709117761
更新日期:1997-03-01 00:00:00
abstract::A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128897
更新日期:1982-07-01 00:00:00
abstract::The efflux of Na-24 was investigated in isolated labyrinths from a membrane section containing stria vascularis and spiral ligament in artificial endolymph medium. The efflux curves were calculated and compartmental analyses were made. The theoretical possibility of a exchange of sodium between compartments connected ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121308
更新日期:1975-07-01 00:00:00
abstract::Paclitaxel (Taxol) is an antimicrotubular agent which blocks the cells in the G2/M phase of the cell cycle. Because of this mechanism it is presumed that this drug could function as a radiation sensitizer. The cytotoxic and genotoxic effects of paclitaxel and a combination of paclitaxel and radiation were studied in t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850154793
更新日期:1998-07-01 00:00:00
abstract::Evidence for a common anatomical and physiological substrate for the generation of the background EEG and the vertex-evoked response led to the hypothesis that the EEG can be interpreted as the output from a time varying filter driven by (a) a noise generator responsible for the background activity, and (b) a pulse ge...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128834
更新日期:1977-01-01 00:00:00
abstract:CONCLUSION:In patients with early glottic squamous cell carcinoma (SCC) submitted to CO2 laser endoscopic resection, local disease recurrence was significantly correlated with the presence of positive additional surgical margins on permanent sections. OBJECTIVES:To evaluate the rate of cancer recurrence in patients wi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500316985
更新日期:2006-03-01 00:00:00
abstract::This study was designed to assess the utility of otolith-ocular reflex testing in patients with complete unilateral peripheral vestibular deficits. Ten subjects were given a clinical vestibular test battery (ENG & vertical rotation) and research oriented tests of otolith function including dynamic posturography with h...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139392
更新日期:1995-11-01 00:00:00
abstract::The effects of transdermally administered scopolamine (TTS-scopolamine) (release rate 5 micrograms/h, one and two patches) and dimenhydrinate (100 mg) on caloric, angular acceleration induced and optokinetic nystagmus were examined in 16 volunteers in a randomized double-blind study. All drugs induced a statistically ...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016488509182266
更新日期:1985-05-01 00:00:00
abstract:CONCLUSION:Bilateral electric acoustic stimulation (EAS) effectively improved speech perception in noise and sound localization in patients with high-frequency hearing loss. OBJECTIVE:To evaluate bilateral EAS efficacy of sound localization detection and speech perception in noise in two cases of high-frequency hearin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.951453
更新日期:2015-02-01 00:00:00
abstract::One hundred patients subjected to tonsillectomy because of recurrent acute tonsillitis or tonsillar hypertrophy were evaluated bacteriologically both with ordinary throat culturing and cultures from tonsillar cores. In 26% of the patients H. influenzae was isolated and in 20% beta-haemolytic group A streptococci. Grow...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009107448
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To determine the role of cell proliferation neoplastic progression in the larynx and possibly derive criteria of clinical significance using automated quantitative image analysis. MATERIAL AND METHODS:In a retrospective study involving archival material, the occurrence and location, size, shape and staining ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0001648021000028135
更新日期:2003-08-01 00:00:00
abstract::An in vivo method for the study of mucociliary activity in the human trachea and bronchi is presented. The method is based on a two-way fibre-optic system whereby reflections of light emitted by one glass-fibre and reflected by the cilia are picked up by a second glass fibre and transmitted to a recording unit. The gl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135885
更新日期:1993-09-01 00:00:00
abstract::One hundred and fifty-five patients with complaints indicating acute sinusitis were examined and their symptoms and signs registered. The final diagnosis--maxillary sinus empyema versus not empyema--was established by means of antral aspiration. A computer-based analysis of clinical data demonstrated the significance ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097017
更新日期:1988-03-01 00:00:00
abstract::The possible beneficial effects of carbogen gas (95% O2/5% CO2) inhalation on noise-induced permanent cochlear impairment were investigated. Groups of guinea pigs were exposed to daily 3 1/2-hour presentations of 120 dB of broad-band noise in an atmosphere of either carbogen gas or normal air. Other groups received ca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130889
更新日期:1982-05-01 00:00:00
abstract::Detailed longitudinal studies of speech perception, speech production and language acquisition have justified a significant change in the demographics of congenitally and prelingually deaf children who receive cochlear implants. A trend toward earlier cochlear implantation has been justified by improvements in measure...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181701
更新日期:1999-03-01 00:00:00
abstract::A method is described for the intravital microscopic observations of rabbit tracheal mucosa microcirculation during compression with a thin, transparent high volume cuff. The cuff pressure (CP) required to cause complete ischemia in the mucosa over the cartilages was measured and a correlation was found to the mean ar...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137192
更新日期:1979-01-01 00:00:00
abstract::This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent e...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750045983
更新日期:2000-06-01 00:00:00
abstract:CONCLUSIONS:Polytetrafluoroethylene (PTFE) may represent a material that prevents adhesions when implanted in the middle ear. This characteristic can be used to improve the design of prostheses. OBJECTIVE:Prostheses in the middle ear have a relatively high failure rate due to extrusion, deformation and adhesion. Adhes...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500312570
更新日期:2006-02-01 00:00:00