Abstract:
BACKGROUND:The association between type 2 diabetes mellitus (T2DM) and hearing loss has not been fully investigated and there is little information on the effects of pre-diabetes on alterations in auditory function in Chinese subjects. METHODS:The study recruited 51 patients with T2DM, 55 patients with pre-diabetes and 43 control subjects. Auditory function was assessed by pure tone audiometry (PTA) tests and distortion product of otoacoustic emissions (DPOAEs). Tinnitus symptoms were recorded using a medical history questionnaire. RESULTS:A significantly larger number of patients with T2DM (45.1%) were affected by hearing loss, compared to pre-diabetes patients (23.6%; p = .04) and control subjects (25.6%; p = .02), as assessed by PTA. There was no significant difference in PTA between the number of pre-diabetes patients and control subjects. In contrast, mean DPOAEs amplitudes of the pre-diabetes patients were significantly lower than of the control subjects, at all frequencies investigated, except 0.75 kHz. A significantly greater number of pre-diabetes patients reported tinnitus symptoms. CONCLUSIONS:Diabetes is associated with bilateral sensorineural hearing loss, especially at high frequencies. While pre-diabetes is not necessarily associated with significant hearing loss, there may be cochlear malfunction, as indicated by DPOAEs. Thus, patients with pre-diabetes who have tinnitus may benefit from DPOAEs and PTA tests.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Li J,Zhang Y,Fu X,Bi J,Li Y,Liu B,Zhang Ldoi
10.1080/00016489.2017.1422084subject
Has Abstractpub_date
2018-06-01 00:00:00pages
542-547issue
6eissn
0001-6489issn
1651-2251journal_volume
138pub_type
杂志文章abstract::In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809124749
更新日期:1978-09-01 00:00:00
abstract::Spiral ganglia of guinea pig and mouse were investigated by scanning electron microscopy (SEM). The cochlea was freeze-fractured and then macerated with 0.1% OsO4 solution for 70-90 h (A-O-D-O method (1]. This allowed three-dimensional observation of the general view of the spiral ganglion and the intracellular struct...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127528
更新日期:1989-05-01 00:00:00
abstract::Substance P has been proved an important neurotransmitter and neuromodulator, serving not only as an excitatory transmitter of the first afferent synapse of pain pathways but as a valuable neuromodulator in the primary cortical areas of sensosensorial integration. In the human acoustic cortex, substance P has been fou...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127525
更新日期:1989-05-01 00:00:00
abstract::Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. The histogenesis of spindle cell tumours has been much debated, but electron microscopic investigations have shown that most of the laryngeal lesions are squamous epithelial carcinomas that have undergone tra...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107550
更新日期:1984-07-01 00:00:00
abstract:CONCLUSION:Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16 (HPV16)-related squamous cell carcinoma of the head and neck (HNSCC). OBJECTIVES:To evaluate the effectiveness of siRNA targeting E6 and/or E7 on the in vitro and in vivo growth ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.773405
更新日期:2013-07-01 00:00:00
abstract::Although still the subject of discussion, vestibular-evoked myogenic potentials (VEMPs) have been considered to reflect the function of the saccular and, more recently, the cochlear tracts. To accurately determine the precise afferent pathway carrying VEMPs, we studied the outcomes of VEMPs and other examinations in p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Five temporal bones and three surgical cochlear nerve specimens from patients who previously underwent labyrinthectomy were studied by light and electron microscopy. All cochleas had nearly total loss of sensory cells, extensive or total loss of both cochlear nerve fibers in the osseous spiral lamina, and spiral gangl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109138495
更新日期:1981-03-01 00:00:00
abstract::Racial differences in the size, shape and structure of the cranium exist. This paper evaluates the importance of race in influencing the required sizes of craniotomies for gaining access to the lateral end of the internal auditory meatus without breaching the labyrinth via the retrosigmoid approach. Fine-cut CT scans ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139402
更新日期:1995-11-01 00:00:00
abstract::The nystagmus and motion perception of two astronauts were recorded during Earth-vertical axis rotation and during off-vertical axis rotation (OVAR) before and after 7 days of spaceflight. Postflight, the peak velocity and duration of per- and postrotatory nystagmus during velocity steps about the Earth-vertical axis ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139374
更新日期:1995-09-01 00:00:00
abstract:CONCLUSIONS:The most likely cause of lesions with an absence of the long process of the incus was congenital origin because many cases were associated with the stapedial anomaly. However, the possibility of a potential inflammation of this lesion could not be completely excluded, especially in cases with only an absenc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601075449
更新日期:2007-08-01 00:00:00
abstract:CONCLUSION:Chemosensory event-related potentials (CSERPs) were identified in all measurements using the 20 s and the 10 s inter-stimulus interval (ISI) protocol, reducing the recording time to 75% or 57% compared with the standard protocol. A possible explanation for the rising CSERP amplitudes by shortening the ISI in...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480802644605
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:As tympanotomy using the transcanal approach was a routine surgical technique for traumatic ossicular disruption, the efficacy of the posterior tympanum approach was rarely explored. AIM:This study aimed to investigate whether the hearing outcomes improved after simultaneous ossiculoplasty and facial nerve ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1833081
更新日期:2020-11-05 00:00:00
abstract::It has previously been shown that simple compounds with multiple amine groups are ototoxic, the degree of ototoxicity depending on the number of amine groups in the molecule. The relationship between the number of amino groups and ototoxicity in aminoglycoside was studied using kanamycin A and kanamycin B, which conta...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709134700
更新日期:1987-01-01 00:00:00
abstract::Cochlear blood flow in guinea pigs was assessed using histological assessment of various red blood cell and vessel lumen parameters. Cochlear blood flow was either enhanced by administration of carbogen or inhibited by induced positive airway pressure. The resulting enhancement or reduction of blood flow in the cochle...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709109055
更新日期:1987-07-01 00:00:00
abstract::Multimodality therapy of advanced malignant tumours of the head and neck includes surgery, radiotherapy and chemotherapy. However, the cure rate for these tumours is low and guidelines for the selection and timing of therapy are needed. For such guidelines, tumour cell kinetic parameter studies, e.g. cell proliferatio...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309130933
更新日期:1983-01-01 00:00:00
abstract:CONCLUSION:The occult metastasis rate for T2 oral cancer can be reduced by ultrasonography (US). Also, the late metastasis rate is considered to be reduced by combining US with frozen section biopsy (FSB) during supraomohyoid neck dissection (SOHND). OBJECTIVES:Early oral cancer has been reported to show occult metast...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.598553
更新日期:2011-11-01 00:00:00
abstract::The influence of obstructed nasal passages was investigated in l4 patients with allergic rhinitis. Disordered breathing in sleep was found in all patients in the form of periodic breathing, and hypopneic and hyperpneic episodes, associated with characteristic "microarousals' from sleep. Patients had an average of 50 "...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133292
更新日期:1981-11-01 00:00:00
abstract:CONCLUSION:The psychometric characteristics of Standard-Chinese lexical neighborhood test (LNT) confirmed the lexical effects of the four word categories. The established normative baseline can be used in evaluating the word-recognition performance of the hearing-impaired listeners. OBJECTIVES:The purpose of the prese...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016489.2013.840923
更新日期:2014-01-01 00:00:00
abstract::An antimicrobial agent, kanamycin, has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of kanamycin ototoxicity as a function of Rx timing with regard to circadian rhythms. Four groups of comparable weight Sprague-Dawley rats received a daily ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109100749
更新日期:1991-01-01 00:00:00
abstract::This study was performed in order to determine the immunohistochemical expression and distribution pattern as well as the electrophysiological actions of substance P in human vestibular ganglion cells. Substance P-like immunostaining was mainly found in the cytoplasm of small vestibular ganglion cells. In contrast, ne...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137839
更新日期:1996-03-01 00:00:00
abstract::Background: The management of patients with tinnitus who receive middle ear surgery has not been established.Aims: The aim of this study is (1) how many patients who receive middle ear surgery have tinnitus and (2) how educational counselling and middle ear surgery is effective with consistent tinnitus.Subjects and me...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1713397
更新日期:2020-04-01 00:00:00
abstract:CONCLUSION:Speech thresholds measured using Cantonese Hearing in Noise Test (CHINT) and cortical evoked response audiometry (CERA) thresholds were highly correlated with pure-tone behavioral results. Both tests are considered to provide good estimates of hearing thresholds and can be employed to confirm the degree of h...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701642189
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. Eosinophilic CRSwNP (ENP) exhibits a strong tendency for recurrence after surgery. Given that the treatment strategy of ENP differs from that of non-eosinophilic CRSwNP (nENP), clinical diagnostic criteria that distinguish ENP from...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1388540
更新日期:2018-04-01 00:00:00
abstract::In the present study, the protective effect of dexamethasone was analysed following exposure of the cochlea to Pseudomonas aeruginosa Exotoxin A (PaExoA). Four groups of albino Sprague-Dawley rats were used. 20 microl saline was instilled through the tympanic membrane into the round window niche (group A, n = 4); 1 mi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000577
更新日期:2000-03-01 00:00:00
abstract::Taking advantage of a natural experimental situation, we compared, retrospectively, functional results after nasalization and ethmoidectomy for diffuse nasal polyposis. Nasalization was a radical ethmoidectomy systematically removing all the bony lamellae and mucosa within the labyrinth, with large antrostomy, sphenoi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113445
更新日期:1997-07-01 00:00:00
abstract::Test-retest variability of values for directional asymmetry in primary and secondary horizontal optokinetic after-nystagmus (OKAN I and OKAN II, respectively) was studied in 16 apparently healthy subjects. OKAN was induced by 60 s of whole-field optokinetic stimulation at speeds of 60 degrees/s and 90 degrees/s in eit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209100776
更新日期:1992-01-01 00:00:00
abstract::The present study on the anatomy of the human facial nerve is based on the results of a series of gross dissections, and histological and electro-diagnostic examinations. From our findings it follows that there is a definite spatial orientation of the peripheral branches in the facial nerve trunk. The results of the m...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609119946
更新日期:1976-03-01 00:00:00
abstract:CONCLUSION:The curative effect in the group where facial-facial anastomosis (FFA) was delayed for 7 days was similar to that in the immediate FFA group and had a better repair within 60 days. OBJECTIVE:Due to the uncertainty about optimal timing of delayed facial nerve repair, we designed an experimental study in guin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.765967
更新日期:2013-07-01 00:00:00
abstract:UNLABELLED:Abstract Conclusion: The selected scFv antibody could specifically recognize and target nasopharyngeal carcinoma (NPC), and could be applied to clinical diagnosis and therapy. OBJECTIVE:The aim was to construct and screen fully human anti-NPC single chain Fv fusion phage libraries, and to identify the sp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.655861
更新日期:2012-06-01 00:00:00
abstract:CONCLUSION:Our results suggest that patients with migraine or tension-type headache have subclinical deviations of the subjective visual vertical, which may be associated with their subjective imbalance. OBJECTIVES:Patients affected by migraine or tension-type headache often complain of unsteadiness. However, they rar...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802032785
更新日期:2009-01-01 00:00:00