Bone marrow cells as an origin of immune-mediated hearing loss.

Abstract:

:The MRL/lpr mouse, which is homozygous for the recessive lpr genes and has a mutation in the Fas gene encoding a cell-surface receptor for apoptosis, exhibits severe lymphadenopathy and develops systemic lupus erythematosus (SLE)-like disease. It has recently been reported that this mouse also manifests sensorineural hearing loss (SHL) with cochlear pathology at 20 weeks of age. We examined the effects of reconstituting severe combined immunodeficient (SCID) mice with MRL/lpr bone marrow on the development of SHL. These mice normally develop neither SHL nor cochlear pathology. Immune-mediated SHL and cochlear pathology did, indeed, occur following transfer of MRL/lpr bone marrow into SCID mice. These findings suggest that the development of SHL and cochlear pathology observed in MRL/lpr mice and in SCID mice receiving MRL/lpr bone marrow are the result of bone marrow defects rather than the result of a problem intrinsic to the cochlea.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Iwai H,Lee S,Baba S,Tomoda K,Inaba M,Ikehara S,Yamashita T

doi

10.1080/00016480310015344

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

8-12

issue

1

eissn

0001-6489

issn

1651-2251

journal_volume

124

pub_type

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