Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig.

Abstract:

:Reserpine (2 mg/kg and 10 mg/kg, i.p.), an adrenergic blocker, was administered to normal guinea pigs, and samples of serum, CSF, scala tympani perilymph, scala vestibuli perilymph and cochlear endolymph were collected. The concentrations of Na and K in these fluids were then assessed to observe electrolyte distributions. Both Na and K concentrations were reduced in serum. In CSF, the Na concentration was markedly depressed, while the K concentration remained unchanged. Scala tympani perilymph showed a pattern of electrolyte changes similar to that in CSF. In scala vestibuli perilymph, the Na concentration was unaltered, but the K concentration was lowered. Cochlear endolymph exhibited no change of the Na concentration but there was a marked decrease in the K concentration. These changes are thought to be attributable to the indirect blockage of energy producing systems in membrane transport in the inner ear by the reserpine-induced depletion of catecholamines.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Kanoh N,Makimoto K

doi

10.3109/00016488409107540

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

98-104

issue

1-2

eissn

0001-6489

issn

1651-2251

journal_volume

98

pub_type

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