Abstract:
:Nasal polyps is a chronic inflammatory disease of the upper airway characterized by structural abnormalities including stromal fibrosis. Fibroblasts are a rich source of cytokines and inflammatory mediators and are thought to play an important role in the development of fibrosis. In addition, there is considerable evidence for the participation of eosinophils in the pathophysiology of nasal polyps. Although increased numbers of eosinophils are present in nasal polyps, the mechanisms responsible for their selective accumulation are not completely clear. Eotaxin is a chemokine that promotes the selective recruitment of eosinophils. Thus, it may be an important molecule for the recruitment of eosinophils in nasal polyps. The purpose of this study was to investigate whether nasal polyp fibroblasts synthesize eotaxin after stimulation with lipopolysaccharide, IL-1beta or TNF-alpha. Using primary nasal polyp tissue-derived fibroblast lines, we demonstrated that LPS, IL-1beta and TNF-alpha induced the gene expression and protein production of eotaxin in nasal polyp fibroblasts. This responsiveness to LPS, IL-1beta and TNF-alpha was time- and dose-dependent. These findings support the hypothesis that fibroblasts could play an important role in the recruitment of eosinophils in nasal polyps through the production of eotaxin.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Nonaka M,Pawankar R,Saji F,Yagi Tdoi
10.1080/00016489950180478subject
Has Abstractpub_date
1999-01-01 00:00:00pages
816-20issue
7eissn
0001-6489issn
1651-2251journal_volume
119pub_type
杂志文章abstract:CONCLUSIONS:We suggest that age-induced changes of serotonin, N-methyl-d-aspartate receptor (NMDAR), and glutamate decarboxylase (GAD) expression in rats are dependent on the specific location in the central auditory system (CAS). OBJECTIVES:Despite the importance of understanding changes in neurotransmitters during p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.622785
更新日期:2012-01-01 00:00:00
abstract::We investigated the effect of prolonged hypergravity on the otoconial layer of the maculae utriculi and the maculae sacculi in hamsters. The animals were placed in a centrifuge under conditions of 2.5 G, and remained there for 6 months. We then determined the calcium contents of the otoconia with energy dispersive X-r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139297
更新日期:1995-03-01 00:00:00
abstract::Experimental animals (cats) were exposed to tones of 125, 1000, 2000, and 4000 Hz at sound pressure levels in the range 120 to 157.5 dB, and for durations of one hour (1000, 2000, 4000 Hz) or four hours (125 Hz). Pure tone audiograms were obtained for each animal before and after exposure. Post-exposure tests were con...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121336
更新日期:1975-11-01 00:00:00
abstract::The condition of the cochlear vasculature was evaluated in 7 normal guinea pigs subsequent to fatal aortic hemorrhage. The cochleas were prepared for histological analysis using a soft surface preparation technique. The data analysis revealed two statistically significant differences: an increase in the number of aggr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409130986
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:The prognostic factors of facial paralysis complicated by middle ear cholesteatoma (MEC) are largely unknown due to limited reports and smaller sample size. OBJECTIVES:This study aimed to analyze prognostic factors of postoperative outcomes of facial paralysis complicated by MEC. MATERIAL AND METHODS:Clini...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1543951
更新日期:2019-02-01 00:00:00
abstract::The early development of human otoconial membranes was studied by scanning electron microscopy and X-ray microanalysis; 87 specimens, ranging from 7 to 12 weeks gestational age were examined. A few otoconia, which contained calcium, were present in the utricle by the end of the seventh week. By 8 weeks, both the saccu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128884
更新日期:1982-07-01 00:00:00
abstract::In a previous study, the authors described a technique for recording ipsilateral EABRs using the DIGISONIC MXM cochlear implant (Gallégo et al, Acta Otolaryngol (Stockh) 1996; 116: 228-33) and showed that the EABR input/output functions were very similar across electrodes. In the present study a test of electrode func...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709117761
更新日期:1997-03-01 00:00:00
abstract::Background: Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist.Aims: The objective of this systematic review was to provide an overview and rate the certainty of the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1777326
更新日期:2020-10-01 00:00:00
abstract:CONCLUSION:Our results show a significant difference between skin and cholesteatoma biology in vitro. OBJECTIVES:Cholesteatoma disease is a process of destruction characterized by uncontrolled growth of squamous epithelial cells in the middle ear or temporal bone. The pathophysiology behind the cholesteatoma developme...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903413657
更新日期:2010-07-01 00:00:00
abstract:CONCLUSION:Selected patients with Meniere's disease (MD) show an improvement of disability from vertigo after transtympanic ventilation tube insertion, although an effect on vestibular function is not seen if ipsilateral middle ear pressure lower than -50 daPa is used as a selection criterion. OBJECTIVES:Transtympanic...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480902791678
更新日期:2009-12-01 00:00:00
abstract::Formation of carotid artery pseudoaneurysm is uncommon after intensive treatment for head and neck cancer. We encountered a case of postoperative formation of pseudoaneurysm at the left carotid bifurcation in a diabetic man. The risk factors for carotid artery pseudoaneurysm in the patient included diabetes mellitus, ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500437401
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To improve the efficacy of intratympanic therapy using perilymphatic entry through the round window membrane. MATERIAL AND METHODS:The perilymphatic entry characteristics of 2 neutral molecules, mannitol (182.2 Da) and inulin (7,000 Da), were studied. A polyethylene catheter was placed in contact with the gu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001042
更新日期:2003-01-01 00:00:00
abstract:CONCLUSIONS:A large series confirmation may suggest elective neck dissection in cN0 MASPIN-negative oral squamous cell carcinomas (SCCs). Re-activated nuclear MASPIN in association with anti-angiogenic or cytotoxic drugs may be extremely effective in the treatment of laryngeal SCC. OBJECTIVES:MASPIN is a serpin showin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/00016480802256079
更新日期:2009-05-01 00:00:00
abstract::In order to examine evidence of high activity of pinocytosis in capillaries of the stria vascularis, quantitative morphometry of pinocytotic vesicles was carried out ultrastructurally by the horseradish peroxidase (HRP) tracer method. In guinea pigs, there was a significant difference between the stria vascularis and ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:CONCLUSION:The degree of contrast enhancement of the cochlea after intratympanic administration of meglumine gadopentetate (Gd-DTPA) or gadodiamide hydrate (Gd-DTPA-BMA) varies widely among patients with inner ear diseases. There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was place...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.507781
更新日期:2011-02-01 00:00:00
abstract::The basement membrane zone (BMZ) of the epithelium of the vocal folds was investigated electron microscopically in 10 patients suffering from various benign lesions and in 3 controls. Various defects were observed: a thickening by deposition of electron dense material, a loss of normal architecture, and a near absence...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135774
更新日期:1993-01-01 00:00:00
abstract::Simultaneous monitoring in human subjects on the same ear of eardrum displacement by tympanomanometry, and impedance with the electroacoustic bridge, provided information concerning contraction of the stapedius muscle and its effect on eardrum displacement. Extensive control procedures were employed to elicit only the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609107472
更新日期:1976-01-01 00:00:00
abstract::POLGON (Polarized light goniometer) was used to evaluate ataxia during stepping movements in patients with spinocerebellar degeneration (SCD) and Parkinson's disease. The measurements included mean angular change of shoulders (M.A.C.S.) and its coefficient of variation (C.V.). In patients with SCD, the values of M.A.C...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135847
更新日期:1993-07-01 00:00:00
abstract::The Dynamic Illegible E (DIE) test measures visual acuity with head held still while reading a specially designed visual acuity chart of E's. The head is then moved passively and the change in visual acuity is recorded. The DIE test has previously been shown to be very useful for assessing patients with aminoglycoside...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:CONCLUSIONS:The procedure cleared the lesion completely and preserved the physiological function of the external auditory canal. OBJECTIVE:To develop a novel surgical procedure to treat chronic suppurative otitis media (CSOM). To explore the merit of using pedicled temporalis myofascia (PTM) and reconstruction of the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.767987
更新日期:2013-07-01 00:00:00
abstract::Abstract Usage of the Vibrant Soundbridge (VSB) with round window (RW)-Coupler placement at the RW has been shown to successfully treat mixed hearing loss. Coupling between the VSB's floating mass transducer (FMT) and the RW membrane is difficult in the case of sclerosis in the RW and drilling down the bony lip unti...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.649492
更新日期:2012-06-01 00:00:00
abstract::Metal intoxication (mercury and arsenic) in guinea pigs may cause damage to labyrinthine blood vessels by swelling of the endothelial cells, mitochondrial disintegration and sometimes protrusion of endothelial cell cytoplasm herniating into the blood vessel lumen. Chronic mercury intoxication resulted in distorted end...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128869
更新日期:1977-05-01 00:00:00
abstract::Losses (determined by measuring microphonic responses) were essentially identical, regardless of whether produced by admittance of sound into the middle ear via perforations in the tympanic membrane (TM) or in the bulla. With SPLs monitored directly at the TM, losses increased at 12 dB/oct with inverse frequency for f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609119970
更新日期:1976-03-01 00:00:00
abstract:CONCLUSION:The curative effect in the group where facial-facial anastomosis (FFA) was delayed for 7 days was similar to that in the immediate FFA group and had a better repair within 60 days. OBJECTIVE:Due to the uncertainty about optimal timing of delayed facial nerve repair, we designed an experimental study in guin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.765967
更新日期:2013-07-01 00:00:00
abstract::A case-control design was used to assess eye-head-trunk coordination for community-dwelling elders performing a stand-walk task. Eighteen elders with a high risk of falling were matched to 18 subjects with low risk on the basis of age, living status (living alone or with someone) and category of residence (independent...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480152583656
更新日期:2001-09-01 00:00:00
abstract::Two hundred Malaysian patients representing 227 ears with previously untreated cholesteatoma disease were analysed retrospectively in terms of i) type of disease, i.e. primary acquired attic defect or posterior superior retraction pocket and secondary acquired type cholesteatoma; ii) positive history of previous middl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138380
更新日期:1991-01-01 00:00:00
abstract:CONCLUSION:On average, adult CI recipients report a moderate sound quality using the Dutch version of the HISQUI19 questionnaire. These results are correlated with their age, speech perception scores, CI aided hearing thresholds, and the SSQ5 and the APHAB questionnaire. BACKGROUND:The general aim of the study was to ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1066934
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:pH monitoring can reflect the changes in H+ in the airway. OBJECTIVES:To explore the utility of pharyngeal pH monitoring in the diagnosis of laryngopharyngeal reflux disease (LPRD). MATERIAL AND METHODS:Clinical data from 956 suspected LPRD patients from February 2016 to March 2018 were analyzed retrospect...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1571280
更新日期:2019-03-01 00:00:00
abstract:CONCLUSION:The narrowing pattern of the upper airway in obstructive sleep apnea patients may be different in sleep as compared with awake. Three different types of obstruction were observed in these subjects during drug-induced sleep. The different obstruction pattern during drug-induced sleep suggests that different s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480902780242
更新日期:2009-12-01 00:00:00
abstract:CONCLUSION:The necessity of considering cervical tuberculous lymphadenitis (CTL) should be emphasized even today for the differential diagnosis of cervical lymphadenopathy, particularly when it is located in the posterior triangle and supraclavicular regions even in patients without active pulmonary tuberculosis (PTB)....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.789927
更新日期:2013-09-01 00:00:00