Abstract：
:The basement membrane zone (BMZ) of the epithelium of the vocal folds was investigated electron microscopically in 10 patients suffering from various benign lesions and in 3 controls. Various defects were observed: a thickening by deposition of electron dense material, a loss of normal architecture, and a near absence of normal hemidesmosomes and anchoring fibers. Beside these previously reported phenomena, many vesicles carrying electron dense material were found near the plasma membrane. The vesicles were observed at various stages of fusion with the plasma membrane, on the other side of which their content was discharged. In the cytoplasm an increase of mitochondria was seen. The amount of condensed chromatin decreased while the nucleoli increased in comparison with the controls. These observations are suggestive of a hyperactivity of the basal cells of the epithelium in response to vibratory stress.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Dikkers FG,Hulstaert CE,Oosterbaan JA,Cervera-Paz FJdoi
10.3109/00016489309135774subject
Has Abstractpub_date
1993-01-01 00:00:00pages
98-101issue
1eissn
0001-6489issn
1651-2251journal_volume
113pub_type
杂志文章abstract：CONCLUSION:Mouse embryonic stem cells (ESCs) transplanted into the scala tympani are able to migrate in the cochlea of rats deafened with aminoglycoside and partly restore the structure of sensory epithelia of the inner ear. OBJECTIVES:To explore the migration and differentiation of enhanced green fluorescence protein...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2012.720029
更新日期：2013-02-01 00:00:00
abstract：:The MRL/lpr mouse, which is homozygous for the recessive lpr genes and has a mutation in the Fas gene encoding a cell-surface receptor for apoptosis, exhibits severe lymphadenopathy and develops systemic lupus erythematosus (SLE)-like disease. It has recently been reported that this mouse also manifests sensorineural ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480310015344
更新日期：2004-01-01 00:00:00
abstract：:We established new cell lines from head and neck cancer patients for studies of adhesion molecules and cellular behavior in nine patients with primary or metastatic cancer treated at the Asan Medical Center. Explant cultures of fresh tumor tissue were used to develop new permanent tumor cell lines. Lines were tested f...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489709113477
更新日期：1997-09-01 00:00:00
abstract：:Synchronous benign and malignant tumors in the ipsilateral salivary glands are extremely rare. We report a unique case of synchronous unilateral parotid tumors in a 71-year-old man. The main parotid lesion was preoperatively suggested to be adenocarcinoma by fine needle aspiration cytology. A coexisting Warthin's tumo...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480600606707
更新日期：2007-01-01 00:00:00
abstract：:It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar ca...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480701687283
更新日期：2008-06-01 00:00:00
abstract：:The influence of the solitary avian middle ear muscle, the m. stapedius, on auditory sensitivity and sound transmission was investigated in the domestic chicken, Gallus gallus. Electrophysiological recordings of inner ear microphonic potentials (MP) were made in order to determine the effects of calibrated, mechanical...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:The maintenance of upright stance in humans requires the integrative evaluation of vestibular, visual, and proprioceptive information. Recent experiments prove the existence of fast vestibulo-spinal reactions in humans. Their physiological significance for the compensation of sudden external displacements of the body ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488909127518
更新日期：1989-05-01 00:00:00
abstract：:Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated w...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3109/00016489.2015.1113439
更新日期：2016-01-01 00:00:00
abstract：:Mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel of monoclonal antibodies against various lymphocyte subsets and macrophages. Tumours of various staging groups were examined in parallel with cells isolated from patient and donor periphe...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488809119459
更新日期：1988-01-01 00:00:00
abstract：CONCLUSION:The Na-K-2Cl cotransporter-1 (NKCCl) may be essential for the maintenance and functioning of the vestibular morphology in mice and it is strongly expressed in human vestibular end organs. OBJECTIVE:NKCCl is a member of the cation-coupled chloride transporter which participates in salt transport and cell vol...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480510012309
更新日期：2005-12-01 00:00:00
abstract：:The influence of cigarette smoke on the pharyngeal mucosa was investigated in a clinical study and in an experiment on animals. Histologic reports were evaluated according to the Kambic-Lenart classification of hyperplastic aberrations of the throat mucosa. A close dependence of the degree of hyperplasia and the numbe...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016487809121433
更新日期：1978-01-01 00:00:00
abstract：:We examined the mucosa of 50 rat middle ears in an experimental model of acute otitis media, in order to obtain information on the mechanisms of polyp formation. The right middle ear of 25 rats was inoculated with type 3 pneumococci, and the left ear served as a control. The animals were killed, the middle ear bulla r...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489509133351
更新日期：1995-01-01 00:00:00
abstract：:Acoustic rhinometry (AR) evaluates the geometry of the nasal cavity by measuring the minimum cross-sectional area (MCA) and nasal volume (V) by means of acoustic reflection. Understanding the normal and pathologic conditions of the internal nasal cavity using AR is important in the diagnosis of structural abnormalitie...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480152602311
更新日期：2001-10-01 00:00:00
abstract：:The influence of obstructed nasal passages was investigated in l4 patients with allergic rhinitis. Disordered breathing in sleep was found in all patients in the form of periodic breathing, and hypopneic and hyperpneic episodes, associated with characteristic "microarousals' from sleep. Patients had an average of 50 "...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488109133292
更新日期：1981-11-01 00:00:00
abstract：CONCLUSIONS:This study showed that macrophages, B cells, and T cells occurred at different frequencies, localizations, and times after acute laser tympanic membrane perforation. Immunological cells were most prevalent in the proliferative mass adjacent to the annulus region. The cellular immunological response in fresh...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016480802669552
更新日期：2009-11-01 00:00:00
abstract：CONCLUSION:Idiopathic otolithic vertigo (IOV) with relatively long duration of attacks might be caused by endolymphatic hydrops in the otolith organ. OBJECTIVES:To clarify the pathophysiology underlying IOV, episodic tilting or translational sensation attacks by unknown causes, especially the possibility of endolympha...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2015.1022834
更新日期：2015-01-01 00:00:00
abstract：:Beta 2-microglobulin (beta 2m) is a small polypeptide, related to the immunoglobulins and present on nucleated cells as part of the strong transplantation antigens. Elevated plasma levels have been recorded in patients with various malignant diseases. Human beta 2m has also been detected immunohistochemically in carci...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488409107571
更新日期：1984-09-01 00:00:00
abstract：:The nasal mucosa and the autonomic nervous regulation of protective reflexes plays an important role for the protection of the lower airways. Increasing experimental evidence from both animal models and humans suggests that the organization of the autonomic nervous pathways is more complicated than previously assumed....
journal_title：Acta oto-laryngologica
pub_type： 杂志文章,评审
doi：10.3109/00016489309135832
更新日期：1993-05-01 00:00:00
abstract：CONCLUSION:Although this study did not show higher risk of oropharyngeal malignancy in HIV patients overall, they still had much higher prevalence of NHL as well as HL than HIV negative patients. Presence of cervical lymphadenopathy is unreliable in differentiating malignant oropharyngeal tumours from benign lymphoid h...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2016.1170878
更新日期：2016-09-01 00:00:00
abstract：:This study was designed to investigate morphological changes in the tympanic membrane (TM) associated with cholesteatoma formation in experimental animals following application of propylene glycol to the middle ear. A 50% solution of propylene glycol was applied bilaterally to the middle ear cavities of 30 young-adult...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488909107401
更新日期：1989-07-01 00:00:00
abstract：:Almost all the pathological and physiological process that effect the nose will change the volume of the airspace within it. This volume has previously been difficult to measure but a new method that calculates this space has been developed. A mechanical model was built to test the physical parameters involved in maki...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489709117791
更新日期：1997-03-01 00:00:00
abstract：:Blood circulation in the cochlear lateral wall after exposure to a non-physiological level of sound (120-125 dB SPL, 3 h) was investigated immunohistologically. Kanamycin (KM), which was expected to function as a tracer of blood flow, was administered to guinea pigs 5 min to 21 h after sound termination. At 5-30 min, ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489109137358
更新日期：1991-01-01 00:00:00
abstract：CONCLUSION:The Finnish Matrix Test is the first sentence test in noise for the Finnish language. It was developed according to the HearCom standards and provides reliable speech intelligibility measurements with highly comparable results with the other international matrix tests. OBJECTIVES:The aim of the study was to...
journal_title：Acta oto-laryngologica
pub_type： 临床试验,杂志文章
doi：10.3109/00016489.2014.898185
更新日期：2014-07-01 00:00:00
abstract：:Earlier investigation did not show any clear distinctive pathological features that differentiate vocal polyps from vocal nodules. The light microscopic distinctive features between the two lesions point in the direction of a more pronounced epithelial reaction and a more fibrous stromal change in vocal nodules. In th...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488809119505
更新日期：1988-05-01 00:00:00
abstract：:683 tumour fragments from 63 head and neck carcinoma patients were cultured in vitro. Two laryngeal carcinomas and two salivary gland carcinomas were established into permanent cell lines. Malignancy of these cultured cells was proved by cloning, by chromosomal analysis and by transplantation into athymic (nu/nu) mice...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488309130956
更新日期：1983-03-01 00:00:00
abstract：:A homozygous mutant rat at the white spotting (Ws) locus showing a deficiency of melanocytes has recently been found (4, 5). The function and morphology of the inner ear of the Ws/Ws rat were examined by auditory brainstem response (ABR), endocochlear DC potential (EP), and electron microscopy. The mean ABR threshold ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489409126038
更新日期：1994-03-01 00:00:00
abstract：:Cochlear microphonics (CM) were recorded in the guinea pig using differential recording from the first and third cochlear turns as well as by using a 10-electrode array inserted in the scala tympani of the basal turn. The excitation profile as represented by the CM was quantified by amplitude and phase data, and was m...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016487809121465
更新日期：1978-05-01 00:00:00
abstract：CONCLUSION:The technology of stimulation rates between 1500 and 5000 pulses per second per channel (pps/ch) brings a benefit for all users. However, the fastest possible rate does not necessarily lead to best hearing performance in each individual subject. Individual optimization of stimulation rate is recommended. OB...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016480902971239
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To investigate the outcome of surgically managed laryngeal carcinoma patients attending an outpatient clinic over a 5-year period. MATERIAL AND METHODS:This was an analytical, retrospective, cross-sectional study. A total of 36 laryngeal carcinoma patients who were managed surgically with or without radiothe...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480410018070
更新日期：2004-08-01 00:00:00
abstract：:The gas nitric oxide (NO) is present in high concentrations in human nasal airways. Since NO is known to inhibit the growth of bacteria and viruses, it has been suggested that airborne NO represents the first line of defence against pathogens in the upper airways. Low nasal NO levels have been reported previously in p...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/000164800750000676
更新日期：2000-03-01 00:00:00
