Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma.

Abstract:

CONCLUSIONS:In computer-assisted analysis of acinic cell cancer (ACC) morphological characteristics of CD34 immunoreactivity were detected. Bigger vessel size, vessel irregularity, and lower intensity of CD34-positive vessel staining may indicate unfavorable prognosis. OBJECTIVES:Salivary gland cancer (SGC) is a morphologically diverse group of malignancies, the most common histological types being mucoepidermoid, adenoid cystic and ACC, which has the most favorable prognosis of the three. The aim of this research was to study the applicability of automated image analysis as prognostic criteria in ACC. PATIENTS AND METHODS:In a nationwide study covering SGC patients in Finland during 1991-1996, 34 patients with ACC (15 males, 19 females, aged 19-95 years, mean 55 years) were included. Parameters were measured from CD34-stained samples. RESULTS:In all, 10 385 vessels were measured, of which 9873 were from specimens from patients who were alive 5 years after treatment (n=32, group I) and 512 were from patients who died of disease (n=2, group II). The following results were found in group II versus group I: mean vessel size 469 microm vs 272 microm (p=0.024); vessel irregularity 28.3 microm vs 22.3 microm (p<0.001); CD34 staining intensity 0.555 microm vs 0.584 microm (p=0.024).

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Luukkaa H,Laitakari J,Vahlberg T,Klemi P,Grénman R

doi

10.1080/00016480601053099

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

869-73

issue

8

eissn

0001-6489

issn

1651-2251

pii

772811191

journal_volume

127

pub_type

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