M2-polarized tumour-associated macrophages in stroma correlate with poor prognosis and Epstein-Barr viral infection in nasopharyngeal carcinoma.

Abstract:

OBJECTIVES:To assess the relationships between CD163 expression, localization of CD163+ macrophages, clinicopathological features and prognosis of NPC. METHODS:A total of 110 cases of NPC specimens and 80 cases of nasopharyngitis specimens were analysed for CD163 expression by immunohistochemistry and EBERs expression in situ hybridization. RESULTS:CD163 + macrophages in the tumour stroma were positively correlated with the tumour and nodal stage. Higher expression of Epstein-Barr virus-encoded RNAs (EBERs) in the nuclei of tumour cells was associated with higher density of CD163 + macrophages in the tumour stroma. More importantly, greater infiltration of CD163 + macrophages in the tumour stroma was associated with poor overall survival (OS) and poor progression-free survival (PFS). Multivariate analysis revealed that the density of CD163+ macrophages in the tumour stroma may be an independent risk factor for NPC prognosis. CONCLUSIONS:Increased infiltration of CD163+ macrophages in the tumour stroma correlates with worse outcomes and with Epstein-Barr virus (EBV) infection status of tumour cells in nasopharyngeal carcinoma (NPC).

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Huang H,Liu X,Zhao F,Lu J,Zhang B,Peng X,Zhang M,Chen X,Li G,Li X

doi

10.1080/00016489.2017.1296585

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

888-894

issue

8

eissn

0001-6489

issn

1651-2251

journal_volume

137

pub_type

杂志文章
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