Abstract:
:The aim of this study was to evaluate histologic changes after long-term administration of the topical nasal decongestants phenylephrine and oxymetazoline. Ninety healthy rabbits were divided into 3 groups for topical administration for 1 week, 2 weeks, and 4 weeks. Each group was subdivided into 3 subgroups by topical administration of phenylephrine. oxymetazoline, and physiologic saline as controls. Each study group thus consisted of 10 rabbits. Phenylephrine was administered by 2 puffs in the left nostril 5 times daily and oxymetazoline by 2 puffs twice a day using metered sprayers giving 0.10 ml in each puff with a dosage used in clinical practice. For statistical significance the Kolmogorov-Smirnov test was used. Light and electron microscopic examination were performed after obtaining nasal respiratory mucosa from the nasal septum of the rabbits. Administration of phenylephrine and oxymetazoline for more than 2 weeks caused histologic changes including ciliary loss, epithelial ulceration, inflammatory cell infiltration and subepithelial edema, and the changes were more pronounced with increasing administration duration of the decongestants. Ciliary loss was prominent in the 4-week phenylephrine and oxymetazoline groups. There were significantly severer changes in the morphologic variables in the decongestant groups compared with the control group according to administration duration (p < 0.05). Dilatation or vacuolization of mitochondria and endoplasmic reticula and vesicles ill the cytoplasm were observed in the 2- and 4-week phenylephrine groups as well as the 2- and 4-week oxymetazoline groups. Mild widening of the intercellular space was observed in the 4-week phenylephrine group. Purulent maxillary sinusitis developed in 6 of 10 rabbits treated for 4 weeks with phenylephrine. The results of this study suggest that the administration of decongestants may cause ciliary loss with subsequent inflammatory changes in the nasal respiratory mucosa.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Suh SH,Chon KM,Min YG,Jeong CH,Hong SHdoi
10.3109/00016489509139384subject
Has Abstractpub_date
1995-09-01 00:00:00pages
664-71issue
5eissn
0001-6489issn
1651-2251journal_volume
115pub_type
杂志文章abstract:BACKGROUND:Many patients with coronavirus disease 2019 (COVID-19) complain from olfactory dysfunction (OD). Aims/objectives: To evaluate the prevalence, prognosis, and recovery from OD in COVID-19 patients. MATERIAL AND METHODS:In this study, patients with COVID-19 symptoms who were referred to six different tertiary ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1836397
更新日期:2020-11-11 00:00:00
abstract::Endoscopy is needed for reliable evaluation of the treatment of nasal polyposis. In this study, we compared the reproducibility of various score systems for staging nasal polyposis and the inter-individual variations between investigators. The mass of the polyps was assessed by five methods, three new techniques (numb...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800760370873
更新日期:2000-01-01 00:00:00
abstract:CONCLUSION:Early intervention may change the natural course of allergic rhinitis, preventing the progression to asthma. In particular, immunotherapy guarantees remission of local symptoms and valid protection against local and bronchial complications. Symptomatic treatment represents a valid alternative; it is always t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.815362
更新日期:2013-11-01 00:00:00
abstract::Alloplastic materials have been used in middle ear reconstruction since 1952. Biologically, biomaterials and specifically ceramics can be defined as being bioinert, bioactive or biodegradable; these terms being descriptive of the biochemical response provoked by the material in the host tissue. Various ceramics, carbo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1992.11665426
更新日期:1992-01-01 00:00:00
abstract::The three-dimensional distribution of the cricoid area was investigated using computer graphics and its histological structure and pathology were studied using whole-organ serial sections. A total of 26 adult human larynges were examined. The findings were as follows: 1. Cricoid areas were located along the superior p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract:CONCLUSION:Nasal obstruction, rhinorrhea, and the amount of rhinorrhea that confidently reflect the parasympathetic stimulation can be used to more precisely predict nonspecific nasal hyper-reactivity (NHR). OBJECTIVE:We aimed to identify factors that confidently reflected the presence and the degree of NHR, measured ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.681798
更新日期:2012-10-01 00:00:00
abstract::Most epidemiological surveys concerning populations exposed to occupational noise or random populations have shown that the left ear is slightly but significantly poorer than the right ear, especially at frequencies most susceptible to noise damage. To experimentally study the possible left-right asymmetry in response...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138399
更新日期:1991-01-01 00:00:00
abstract:CONCLUSION:Continuous positive airway pressure (CPAP) therapy improved not only apnea-hypopnea during sleep and sleep structure but also sleep-related deglutition, especially respiratory phase patterns associated with deglutition. OBJECTIVES:Sleep-related deglutition and related respiratory phase patterns in patients ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.520166
更新日期:2011-02-01 00:00:00
abstract::Following responses to constant velocity and sinusoidally oscillating movements of the whole visual environment were examined in normal subjects wearing blinkers to obscure central vision or subjected to a photo flash to induce a central scotoma, in patients with central scotomas of pathological origin and in one pati...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909126455
更新日期:1979-05-01 00:00:00
abstract:CONCLUSION:We demonstrated an early increase in aquaporin 2 (AQP2) expression in a motor nerve (extratemporal facial nerve, FN) following acute peripheral compression (crush), concomitant to effective development of motor dysfunction (facial palsy). The early increase in AQP2 expression that occurred concomitantly with...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1010104
更新日期:2015-07-01 00:00:00
abstract::We studied the influence of neck afferents on the perception of orientation. In Experiment 1, we investigated the effect of head tilt on the subjective vertical in both the visual and tactile modalities. The results showed that head tilt triggers an Aubert effect in the visual modality and a Müller effect in the tacti...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000261
更新日期:2000-09-01 00:00:00
abstract::Recent studies have implicated nitric oxide (NO) in neuronal degeneration and plasticity in the motor nervous system. In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (RLN) using nicotina...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750001198
更新日期:2000-03-01 00:00:00
abstract::We investigated the postoperative conditions of ears and the hearing acuity of patients who underwent posterior canal wall reconstruction tympanoplasty for operated ears with open mastoid. The study included 118 ears of 105 patients (57 males, 48 females; age range 5-75 years) and the patients were followed for > 1 ye...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164802753648114
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To improve the efficacy of intratympanic therapy using perilymphatic entry through the round window membrane. MATERIAL AND METHODS:The perilymphatic entry characteristics of 2 neutral molecules, mannitol (182.2 Da) and inulin (7,000 Da), were studied. A polyethylene catheter was placed in contact with the gu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001042
更新日期:2003-01-01 00:00:00
abstract::In the present study cholinesterase histochemical (ChE) techniques have been used to demonstrate differentiation and maturation of the medial geniculate body (MGB) in the human fetuses (ranging between 10.5 to 28 weeks) and infants (premature and three postnatal months). In the youngest specimens examined (10.5 to 15 ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139464
更新日期:1983-05-01 00:00:00
abstract:CONCLUSION:The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosom...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701813822
更新日期:2008-09-01 00:00:00
abstract:CONCLUSIONS:Endoscopic laser microsurgery (ELM) provides comparable oncological outcomes, and improved functional recovery and laryngeal preservation compared with open partial laryngopharyngectomy (OPLP) in patients with early squamous cell carcinoma of the hypopharynx (HPSCC). The use of open surgery is declining. Th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.805341
更新日期:2013-10-01 00:00:00
abstract:UNLABELLED:Abstract Conclusions: In survival analysis, the combined Charlson comorbidity index (CCI) can be considered as a prognostic factor independent of the tumor node metastasis (TNM) classification, tumor stage, and tumor location. Severe comorbidity was the factor that had the greatest impact on prognosis in cas...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.564651
更新日期:2011-08-01 00:00:00
abstract:CONCLUSION:The necessity of considering cervical tuberculous lymphadenitis (CTL) should be emphasized even today for the differential diagnosis of cervical lymphadenopathy, particularly when it is located in the posterior triangle and supraclavicular regions even in patients without active pulmonary tuberculosis (PTB)....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.789927
更新日期:2013-09-01 00:00:00
abstract:CONCLUSION:Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. OBJECTIVE:Prognostic f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480802642096
更新日期:2009-11-01 00:00:00
abstract::We evaluated the vestibulo-ocular reflex (VOR) in 50 normal human subjects, uniformly distributed in age 20-59 years, and evenly distributed in sex by decade, using sinusoidal rotation over the frequency range of 0.005 to 1.0 Hz and three peak amplitudes of 25, 50, and 100 deg/sec. Age variations. The gain magnitude o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107563
更新日期:1984-09-01 00:00:00
abstract::Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in the Western world in recent years. Human papillomavirus (HPV) infection is established as the main explanation.Aims/objectives: This study aims to review the most recently published studies on the repartition of HPV-positive ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1669820
更新日期:2019-12-01 00:00:00
abstract::Test-retest variability of values for directional asymmetry in primary and secondary horizontal optokinetic after-nystagmus (OKAN I and OKAN II, respectively) was studied in 16 apparently healthy subjects. OKAN was induced by 60 s of whole-field optokinetic stimulation at speeds of 60 degrees/s and 90 degrees/s in eit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209100776
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to show the early stages of polyp formation, as part of our studies on the pathogenesis of nasal polyps. Two and 4 weeks after experimental tubal occlusion in 18 Wistar rats, 13 showed signs of bacterial infection, respective acute otitis media. In the majority of these rats polypouslike ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138432
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the capability of indirect computed tomography and magnetic resonance lymphography (CT/MR-LG) with gadolinium-loaded, polyethylenimine-entrapped gold nanoprobes (Gd-Au PENPs) for assessing lingual sentinel lymph node (SLN) metastasis in a tongue VX2 carcinoma model. MATERIALS AND METHODS:Seventee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1441544
更新日期:2018-08-01 00:00:00
abstract::The main parameters of the vestibulo-ocular reflex (i.e. the gain or reflectivity, the long-time constant of the semicircular canals, the time constant of the mechano-neural transduction, and that of the central leaky integrator) were computed from the post-rotational nystagmic responses of unilateral Meniere's patien...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121469
更新日期:1978-05-01 00:00:00
abstract::Fibroblasts in two portions of the vocal fold mucosa, the macula flava (MF) and Reinke's space (RS), were investigated by means of transmission electron microscopy. Five adult and five newborn larynges from autopsy cases were subjected to study. Both in adults and newborns, fibroblasts in the MF tended to be stellate ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181800
更新日期:1999-03-01 00:00:00
abstract:CONCLUSION:The developed software (HITCal) may be a useful tool in the analysis and measurement of the saccadic video head impulse test (vHIT) responses and with the experience obtained during its use the authors suggest that HITCal is an excellent method for enhanced exploration of vHIT outputs. OBJECTIVE:To develop ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1035401
更新日期:2015-09-01 00:00:00
abstract::Contact endoscopy allows an in vivo and in situ study of the superficial layers of the vocal cord epithelium. This technique offers access to some characteristics of the epithelium cells: dimension and shape of the nuclei, nucleus/cytoplasm ratio, keratosis, presence of nucleolus, mitosis and koylocites. Contact endos...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139318
更新日期:1995-03-01 00:00:00
abstract::Five temporal bones and three surgical cochlear nerve specimens from patients who previously underwent labyrinthectomy were studied by light and electron microscopy. All cochleas had nearly total loss of sensory cells, extensive or total loss of both cochlear nerve fibers in the osseous spiral lamina, and spiral gangl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109138495
更新日期:1981-03-01 00:00:00