Induction of nitric oxide synthase activity in nucleus ambiguus motoneurons after injury to the rat recurrent laryngeal nerve.

Abstract:

:Recent studies have implicated nitric oxide (NO) in neuronal degeneration and plasticity in the motor nervous system. In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (RLN) using nicotinamide-adenine-dinucleotide-phosphate-diaphorase (NADPH-d) histochemistry. NADPH-d reactivity was clearly induced in motoneurons in the ipsilateral NA after transection or avulsion of the RLN, compared with control animals. This finding suggests that NO may play an important role in the pathogenesis of RLN paralysis. Another interesting finding in the present study was the induction of NADPH-d reactivity in nerve terminals of the NA after RLN injury. This finding suggests that RLN injury has some effect on nitrergic input to the NA and a direct effect on the motoneurons.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Bamba H,Uno T,Koike S,Shogaki K,Hisa Y

doi

10.1080/000164800750001198

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

327-9

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

120

pub_type

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