Doxorubicin ototoxicity is induced in mice by combination treatment with cyclosporin A.

Abstract:

:Although doxorubicin [adriamycin (ADM)] ototoxicity has not been detected to date, it has been reported that neurotoxicity in the central nervous system was induced by chemotherapy with ADM in patients receiving chronic cyclosporin A (CsA) treatment. ADM ototoxicity may be induced by combination therapy with CsA because extrusion of ADM from the inner ear by p-glycoprotein (p-gp), which acts as an extrusion pump and is expressed on the surface of endothelial cells of capillary blood vessels, might be inhibited by CsA. resulting in significant accumulation of ADM in the inner ear. ADM (10 mg/kg) was administered to FVB mice either with or without CsA (200 mg/kg). Auditory brainstem responses (ABRs) were recorded before and after treatment. ABR changes were not observed in mice treated with either ADM or CsA alone. Threshold elevation, elongation of wave I-V latencies and interpeak latencies of waves I-II, I-III, I-IV and I-V were detected in mice treated with ADM in combination with CsA. These changes reached their peak values 3 weeks after treatment, and then recovered to pre-treatment levels. In normal mice, ADM is extruded by p-gp from the inner ear and auditory pathway, thus preventing hearing disorder. However, ADM ototoxicity was induced by combination therapy with CsA, indicating that CsA has an inhibitory action on p-gp function in the auditory pathway, including the inner ear. After organ transplantation, therefore, clinical administration of ADM in combination with CsA should be performed with caution.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Saito T,Zhang ZJ,Tokuriki M,Shibamori Y,Yamamoto T,Noda I,Ohtsubo T,Saito H

doi

10.1080/00016480152602212

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

787-93

issue

7

eissn

0001-6489

issn

1651-2251

journal_volume

121

pub_type

杂志文章
  • Type 2 thyroplasty for spasmodic dysphonia: fixation using a titanium bridge.

    abstract:OBJECTIVE:In order to facilitate surgery for spasmodic dysphonia, i.e. type 2 thyroplasty, a device was designed to fix the incised edges of the thyroid cartilage firmly. MATERIAL AND METHODS:Various types and sizes of titanium bridge were developed for clinical use. RESULTS:The results of surgery for spasmodic dysph...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016261

    authors: Isshiki N,Yamamoto I,Fukagai S

    更新日期:2004-04-01 00:00:00

  • Manometric rhinometry: a new method of measuring the volume of the air in the nasal cavity.

    abstract::Almost all the pathological and physiological process that effect the nose will change the volume of the airspace within it. This volume has previously been difficult to measure but a new method that calculates this space has been developed. A mechanical model was built to test the physical parameters involved in maki...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709117791

    authors: Porter MJ,Maw AR,Kerridge DH,Williamson IM

    更新日期:1997-03-01 00:00:00

  • The free radical forearm flap: a reliable method for reconstruction of the laryngohypopharynx after in-continuity resection.

    abstract::Between 1992 and 1996 14 patients with a squamous cell carcinoma of the laryngohypopharynx underwent tumour resection and primary reconstruction with the free volar forearm flap. Tumour resection was performed by a head and neck surgeon and reconstruction by a plastic surgeon. Preoperative radiotherapy was given to 13...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850183548

    authors: Stark B,Nathanson A

    更新日期:1998-06-01 00:00:00

  • Comparison of functional results after ethmoidectomy and nasalization for diffuse and severe nasal polyposis.

    abstract::Taking advantage of a natural experimental situation, we compared, retrospectively, functional results after nasalization and ethmoidectomy for diffuse nasal polyposis. Nasalization was a radical ethmoidectomy systematically removing all the bony lamellae and mucosa within the labyrinth, with large antrostomy, sphenoi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709113445

    authors: Jankowski R,Pigret D,Decroocq F

    更新日期:1997-07-01 00:00:00

  • Carotid artery pseudoaneurysm as a rare sequela of surgery for laryngeal cancer.

    abstract::Formation of carotid artery pseudoaneurysm is uncommon after intensive treatment for head and neck cancer. We encountered a case of postoperative formation of pseudoaneurysm at the left carotid bifurcation in a diabetic man. The risk factors for carotid artery pseudoaneurysm in the patient included diabetes mellitus, ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500437401

    authors: Iguchi H,Takayama M,Kusuki M,Nakamura A,Kanazawa A,Hachiya K,Yamane H

    更新日期:2006-05-01 00:00:00

  • Preparation of human scFv antibody against nasopharyngeal carcinoma and identification of its specificity.

    abstract:UNLABELLED:Abstract Conclusion: The selected scFv antibody could specifically recognize and target nasopharyngeal carcinoma (NPC), and could be applied to clinical diagnosis and therapy. OBJECTIVE:The aim was to construct and screen fully human anti-NPC single chain Fv fusion phage libraries, and to identify the sp...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.655861

    authors: Li YD,Li YH,Zhao Y,Wang JJ,Xie PL,Guo FJ,Ren CP,Li GC

    更新日期:2012-06-01 00:00:00

  • Postnatal development of the auditory evoked brainstem potentials in the guinea pig.

    abstract::The postnatal development of lower stations in the auditory pathway was studied in the guinea pig by recording auditory brainstem potentials. At birth, the brainstem responses of young guinea pigs already have thresholds corresponding to those of adult animals. However, the latencies of the individual potentials are s...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409130965

    authors: Dum N

    更新日期:1984-01-01 00:00:00

  • Source and role of endolymph macromolecules.

    abstract::Evaluation of some 200 endolymph proteins indicates that they are predominantly derived from plasma. However, the profile of endolymph proteins is remarkably similar to that of perilymph and entirely different from that of plasma. This supports the current consensus that perilymph rather than plasma is the (direct) so...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/00016489950181260

    authors: Thalmann R,Thalmann I

    更新日期:1999-01-01 00:00:00

  • Immunohistochemical distribution of fibronectin in the mucosa with chronic sinusitis.

    abstract::The distribution of fibronectin (FN) in operative specimens of maxillary sinus mucosa from 35 patients with chronic sinusitis was examined immunohistochemically. Mouse monoclonal antibody to human FN was used for the peroxidase-antiperoxidase staining technique. FN was found in most of the serous cells and in some (ab...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109137365

    authors: Ito O,Suzaki H,Nomura Y

    更新日期:1991-01-01 00:00:00

  • Comparison of vestibular function between large cerebellopontine angle meningioma and schwannoma.

    abstract:CONCLUSION:Abnormal caloric and vestibular evoked myogenic potential (VEMP) responses are frequently encountered with a large cerebellopontine angle (CPA) schwannoma, while normal caloric responses and abnormal VEMPs are noted with a large CPA meningioma. This difference may possibly exist because schwannoma causes ves...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802126553

    authors: Hu YF,Cheng PW,Young YH

    更新日期:2009-02-01 00:00:00

  • Is there a deafness duration limit for cochlear implants in post-lingual deaf adults?

    abstract:CONCLUSION:Patients with post-lingual deafness should not be excluded from cochlear implantation (CI) on the basis of duration of deafness. We found that the prognosis was favorable in patients who developed deafness after adolescence, even in those with extremely long-term deafness. OBJECTIVES:CI is an effective trea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2013.850175

    authors: Moon IS,Park S,Kim HN,Lee WS,Kim SH,Kim JH,Choi JY

    更新日期:2014-02-01 00:00:00

  • Eye movements and motion perception induced by off-vertical axis rotation (OVAR) at small angles of tilt after spaceflight.

    abstract::The nystagmus and motion perception of two astronauts were recorded during Earth-vertical axis rotation and during off-vertical axis rotation (OVAR) before and after 7 days of spaceflight. Postflight, the peak velocity and duration of per- and postrotatory nystagmus during velocity steps about the Earth-vertical axis ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139374

    authors: Clement G,Darlot C,Petropoulos A,Berthoz A

    更新日期:1995-09-01 00:00:00

  • Analysis of symptoms and clinical signs in the maxillary sinus empyema.

    abstract::One hundred and fifty-five patients with complaints indicating acute sinusitis were examined and their symptoms and signs registered. The final diagnosis--maxillary sinus empyema versus not empyema--was established by means of antral aspiration. A computer-based analysis of clinical data demonstrated the significance ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809097017

    authors: Berg O,Carenfelt C

    更新日期:1988-03-01 00:00:00

  • Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome.

    abstract:CONCLUSION:Results from a database for sudden sensorineural hearing loss (SSNHL) demonstrate no correlation between laboratory findings, treatment, and outcome in 400 patients. The patients with pathological test results were not treated differently from those with normal test results. The value of laboratory findings ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480903161541

    authors: Nosrati-Zarenoe R,Hansson M,Hultcrantz E

    更新日期:2010-03-01 00:00:00

  • Can chronic nasal obstruction cause dysfunction of the paratubal muscles and otitis media? An experimental study in developing Wistar rats.

    abstract:OBJECTIVE:To quantitatively analyze modifications of the paratubal muscles in developing Wistar rats following nasal obstruction. MATERIAL AND METHODS:Twenty-four Wistar rats were used. Twelve were examined at 6, 8 and 12 weeks after birth and were considered normal controls. The nostrils of the remaining 12 rats were...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480310001141

    authors: Scarano E,Fetoni AR,Picciotti P,Cadoni G,Galli J,Paludetti G

    更新日期:2003-01-01 00:00:00

  • Unique penetrance of hearing loss in a five-generation Chinese family with the mitochondrial 12S rRNA 1555A > G mutation.

    abstract:CONCLUSIONS:Analysis of the complete mtDNA genome and X-linkage of this five-generation Chinese family revealed that the 1555A > G mutation may lead to deafness. OBJECTIVES:Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. However, the variable clinical phenotype ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.575794

    authors: Men M,Jiang L,Wang H,Liu Y,Hu Z,He C,Feng Y

    更新日期:2011-09-01 00:00:00

  • Selective resection of the semicircular canals of rabbits with preservation of hearing.

    abstract::The goal of this investigation was to develop a method of surgical removal of the semicircular canals of the rabbit without induction of auditory impairment. Four different surgical techniques were utilized: i) fenestration of the lateral semicircular canal; ii) fibrin glue perfusion of the canal following fenestratio...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489209137490

    authors: Gjuric M,Wigand ME,Hosemann W

    更新日期:1992-11-01 00:00:00

  • Early timing of low-dose dexamethasone decreases inflammation in a murine model of eosinophilic airway disease.

    abstract:CONCLUSION:A very low dose of dexamethasone (DEX) was as equally as sufficient as a pharmacological dose to decrease eosinophil inflammation in airways and bone marrow. The timing of DEX treatment in relation to allergen challenge was strongly decisive for the outcome of the inflammatory response. OBJECTIVES:We aimed ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802126561

    authors: Georén SK,Tcacencu I,Wikström AC,Stierna P

    更新日期:2009-02-01 00:00:00

  • Subpixel tracking for the analysis of outer hair cell movements.

    abstract:CONCLUSION:Videomicroscopy with subpixel analysis is an excellent system for quantification of outer hair cell (OHC) movements. The resolution of a few nanometers is accurate enough to show induced differences of electromotility. OBJECTIVE:Electromotility of OHCs is a voltage-dependent process resulting from a membran...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701411502

    authors: Canis M,Ortner M,Olzowy B,Jahn K,Strupp M,Hemmert W,Berghaus A,Suckfuell M

    更新日期:2008-03-01 00:00:00

  • Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy.

    abstract:CONCLUSION:Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.906748

    authors: von Beckerath MP,Reizenstein JA,Berner AL,Nordqvist KW,Landström FJ,Löfgren AL,Möller CG

    更新日期:2014-08-01 00:00:00

  • Experimental surgery on the nose. I. Airflow and goblet-cell density.

    abstract::In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487809124749

    authors: Mogensen C,Tos M

    更新日期:1978-09-01 00:00:00

  • Amplification of int-2 and bcl-1 genes in squamous cell carcinoma of the larynx.

    abstract::We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other am...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850183331

    authors: Miyahara H,Naito H,Ueda K,Yane K,Matsunaga T,Okaichi K,Ohnishi T

    更新日期:1998-09-01 00:00:00

  • Outcome of surgical management of laryngeal carcinoma: a 5-year experience.

    abstract:OBJECTIVE:To investigate the outcome of surgically managed laryngeal carcinoma patients attending an outpatient clinic over a 5-year period. MATERIAL AND METHODS:This was an analytical, retrospective, cross-sectional study. A total of 36 laryngeal carcinoma patients who were managed surgically with or without radiothe...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410018070

    authors: Baskota DK,Prasad R,Sinha BK,Amatya RC,Bhattarai H,Guragain RP

    更新日期:2004-08-01 00:00:00

  • Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application.

    abstract::Basic scientific research has demonstrated that epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor-AA (PDGF-AA) and transforming growth factor-alpha (TGF-alpha) are induced by acute tympanic membrane (TM) perforation. The expression of these growth factors peaks during...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/000164802320396259

    authors: Ma Y,Zhao H,Zhou X

    更新日期:2002-09-01 00:00:00

  • The influence of type of visual image and gender on the perception of horizontality: a subjective visual horizontal (SVH) study.

    abstract:BACKGROUND:The graviceptive otolith function can be measured using subjective visual horizontal (SVH) testing. Nevertheless, more research efforts are required to understand the essential variables affecting SVH. OBJECTIVE:The aim of the present study was to determine the effects of type of visual image and gender on ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1817552

    authors: Zakaria MN,Tahir A,Zainun Z,Salim R,Mohd Sakeri NS,Abdul Wahat NH

    更新日期:2021-01-01 00:00:00

  • The effect of Japanese cedar-specific immunotherapy on cytokine production in peripheral blood mononuclear cells.

    abstract::The most common cause of seasonal allergic rhinitis in Japan is the Japanese cedar (JC). Recently, a pullulan-conjugated antigen (CS-560) has been developed to reduce adverse effects and to enhance the effect of JC-specific immunotherapy (IT). If the mechanism of IT can be fully elucidated and the treatment can be use...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.1080/00016480252775742

    authors: Nakano A,Nakano K,Okawa T,Yamakoshi T,Terada N,Numata T,Konno A

    更新日期:2002-01-01 00:00:00

  • The desynchrony between complaints and signs of vestibular disorders.

    abstract::As part of an early intervention study on the acceptability of auditory rehabilitative intervention, we examined patient complaints and clinical findings of balance disorders. Hallam et al. have discussed desynchrony between such findings in hospital patient populations, and the aim of the present study was to investi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109137373

    authors: Stephens SD,Hogan S,Meredith R

    更新日期:1991-01-01 00:00:00

  • The effects of cochlear implantation in Japanese single-sided deafness patients: five case reports.

    abstract:CONCLUSION:Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. OBJECTIVES:This study reports results for five adult SSD cases with CI, focusing on the benefits they obtained in terms of spee...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00016489.2015.1116046

    authors: Kitoh R,Moteki H,Nishio S,Shinden S,Kanzaki S,Iwasaki S,Ogawa K,Usami S

    更新日期:2016-01-01 00:00:00

  • Electrocochleography used as a clinical hearing test in difficult-to-test children.

    abstract::Thirty difficult-to-test children have been tested with transtympanic ECoG. When possible, informal hearing tests and/or free-field testing were performed. Children in whom no action potential (AP) could be recorded were submitted to conventional radiography of the inner ear, and vestibular tests. The correlation betw...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709123981

    authors: Bergholtz LM,Arlinger SD,Kylén P,Jerlvall LB

    更新日期:1977-11-01 00:00:00

  • Indications of cone beam CT in head and neck imaging.

    abstract:CONCLUSION:Cone Beam Computed Tomography (CBCT) can be widely used in imaging of bony structures of the anterior and lateral skull base. Significant differences of applied dosages result from the different protocols of the various indications. OBJECTIVES:CBCT is increasingly being used in head and neck imaging. Until ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1076172

    authors: Stutzki M,Jahns E,Mandapathil MM,Diogo I,Werner JA,Güldner C

    更新日期:2015-01-01 00:00:00