CD73 expression in lymph node metastases in patients with head and neck cancer.

Abstract:

INTRODUCTION:CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall poor prognosis, also due to early spread of metastatic cells. MATERIALS AND METHODS:Tumor and lymph node specimens of 65 patients with HNSCC were subjected to immunohistochemical and H-score analysis of CD73 expression. Demographics, diagnoses, histopathology and subsequent outcome were analyzed. RESULTS:The primary cancer was squamous cell carcinoma in all patients (male/female 55:10) with the following locations: oral cavity n:16, oropharynx n:28, hypopharynx n:11 and larynx n:10. H-score for CD73 expression in the primary lesion and metastatic lymph nodes was significantly higher in advanced compared to early stages with no significant differences among tumor locations. High CD73 expression was associated with reduced overall survival rates at a mean follow-up of 83.4 months (6-204 months). CONCLUSIONS:CD73 expression in HNSCC correlated positively with tumor stage and was associated with poor prognosis. Therefore, CD73 expression in primary lesions and regional metastases appears to predict HNSCC patients at high risk of all tumor sites. Therapeutic approaches targeting CD73 might seem promising for this patient population.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Mandapathil M,Boduc M,Netzer C,Güldner C,Roessler M,Wallicek-Dworschak U,Jahns E,Stuck B

doi

10.1080/00016489.2017.1378436

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

180-184

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

138

pub_type

杂志文章
  • Plaster of Paris: thermal properties and biocompatibility. A study on an alternative implant material for ear surgery.

    abstract::There is no single technique for reconstruction of the canal wall following radical mastoidectomy. Autograft tissues may be unsuitable because of resorption and limited availability. An ideal foreign implant material should be bone-like in quality, non-ototoxic, readily available and malleable. Plaster of Paris, a deg...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609108631

    authors: Högset O,Bredberg G

    更新日期:1986-05-01 00:00:00

  • Computerized analysis of the caloric response.

    abstract::Caloric responses from 50 consecutive patients, referred routinely for investigation of hearing and/or balance problems, were evaluated by computer and manual methods of analysis. Using measures of nystagmic slow-phase velocity, there was found to be a high degree of correlation between the two methods. Of the 50 pati...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709128267

    authors: O'Neill G,Owen WA

    更新日期:1987-11-01 00:00:00

  • Frequency of serious complications after surgery for snoring and sleep apnea.

    abstract:CONCLUSION:No case of death related to surgery in the form of uvulopalatopharyngoplasty, uvulopalatoplasty or nasal surgery for snoring or sleep apnea has been recorded in Sweden among 4876 patients treated between 1997 and 2005. Severe complications of surgery in the peri- and postoperative period, especially in the f...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.528793

    authors: Franklin KA,Haglund B,Axelsson S,Holmlund T,Rehnqvist N,Rosén M

    更新日期:2011-03-01 00:00:00

  • Vestibular dysfunction causing instability in aged patients.

    abstract::Unilateral vestibular hypofunction (UVH) is a common vestibular dysfunction. Its influence upon the vestibulospinal reflex (VSR) is studied by posturography. The postural sway is disturbed when the VSR is disregulated because of the UVH. The degree of disturbance depends on the effectivity of the central compensation....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709109046

    authors: Norré ME,Forrez G,Beckers A

    更新日期:1987-07-01 00:00:00

  • Efficient transduction of spiral ganglion cells using adenovirus type 5 vector in the rat.

    abstract:CONCLUSIONS:The adenovirus-5 vector specifically transduced spiral ganglion cells with high efficiency, suggesting that it is a potential gene therapeutic tool for the survival of spiral ganglion cells with secondary injury. OBJECTIVES:This study aimed to find a suitable viral vector allowing efficient transduction to...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903510742

    authors: Lei L,Han D

    更新日期:2010-07-01 00:00:00

  • A scanning electron microscopy study of post mortem autolytic changes in the human and rat cochleas.

    abstract::The use of SEM as an adjunct to TEM and electrophysiological examination of the cochlea is now well established. It has provided a relatively simple method of assessing the effect of noise, ototoxic drugs, electrical stimulation, etc. on the surface features of the organ of corti. A controlled experiment was undertake...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509126566

    authors: Gleeson MJ

    更新日期:1985-11-01 00:00:00

  • Thyroplasty type I (lateral compression) for dysphonia due to vocal cord paralysis or atrophy.

    abstract::Based on the experimental results of thyroplasty, thyroplasty type I which aims at medical shifting the vocal cord was performed on 8 patients with dysphonia, 6 with vocal cord paralysis and 2 with vocal cord atrophy. The surgery was conducted on either in- or out-patient basis and local anesthesia was used. Usually, ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509121353

    authors: Isshiki N,Okamura H,Ishikawa T

    更新日期:1975-11-01 00:00:00

  • Divergent expression of α-ENaC in middle ear mucosa in the course of otitis media with effusion induced by barotrauma.

    abstract:CONCLUSION:Gene transcription and protein expression of α-ENaC showed a divergent expression in association with the development of OME induced by barotrauma. OBJECTIVES:ENaC was identified to mediate the fluid absorption through epithelia of the middle ear. This study was designed to investigate the involvement of EN...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1017888

    authors: Xu J,Zong Y,Li X,Zhang Y,Li J

    更新日期:2015-07-01 00:00:00

  • Comparative ototoxicity of kanamycin A and kanamycin B in the guinea pig.

    abstract::It has previously been shown that simple compounds with multiple amine groups are ototoxic, the degree of ototoxicity depending on the number of amine groups in the molecule. The relationship between the number of amino groups and ototoxicity in aminoglycoside was studied using kanamycin A and kanamycin B, which conta...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709134700

    authors: Yung MW

    更新日期:1987-01-01 00:00:00

  • Ultrastructural localization of GABA-like immunoreactivity in the vestibular periphery of the rat.

    abstract::Gamma-aminobutyric acid (GABA) is presumed to be a neurotransmitter candidate in the vestibular periphery of mammals. However, experimental reports about the localization of GABA in afferents or efferents of the vestibular systems are contradictory. It is an open question whether there are species differences in the a...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850155198

    authors: Kong WJ,Hussl B,Thumfart WF,Schrott-Fischer A

    更新日期:1998-01-01 00:00:00

  • Inner ear injury caused by air intrusion to the scala vestibuli of the cochlea.

    abstract::In a previous communication, we demonstrated that the introduction of air into the scala tympani of the cochlea causes a decrease of cochlear potentials; however, the change in endocochlear dc potential (EP) was mild and the decreased cochlear microphonics (CM) and compound action potentials (CAP) were, at least parti...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135892

    authors: Kobayashi T,Sakurada T,Ohyama K,Takasaka M

    更新日期:1993-11-01 00:00:00

  • Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation.

    abstract::Cell proliferation in the endolymphatic sac (ES) after immunostimulation was assessed immunohistochemically. Guinea pigs were employed as experimental animals and keyhole limpet hemocyanin was used as the antigen. After i.p. injection of 5-bromo-2'-deoxyuridine (BrdUrd), the BrdUrd+ cells were counted to assess the nu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139336

    authors: Takahashi M,Tomiyama S

    更新日期:1995-05-01 00:00:00

  • Objective and subjective evaluations of the Nurotron Venus cochlear implant system via animal experiments and clinical trials.

    abstract:CONCLUSION:This study described objective and subjective evaluations of the Nurotron® Venus™ Cochlear Implant System and indicated that this system produced a satisfactory performance. OBJECTIVE:To observe the performance of the Nurotron® Venus™ cochlear implant (CI) system via electrophysiological and psychophysical ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1086022

    authors: Gao N,Xu XD,Chi FL,Zeng FG,Fu QJ,Jia XH,Yin YB,Ping LC,Kang HY,Feng HH,Wu YZ,Jiang Y

    更新日期:2016-01-01 00:00:00

  • Improved speech reception and sound quality with the DUET2 audio processor for electric acoustic stimulation.

    abstract:CONCLUSION:The results show that the DUET2 offers users speech perception that is equivalent to or better than the DUET. Moreover, the DUET2 offers subjective benefits above those provided by the DUET. BACKGROUND:The DUET is a combination of hearing aid and CI in one device for electric acoustic stimulation. Since its...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1050605

    authors: Kleine Punte A,Mertens G,Cochet E,De Bodt M,Van de Heyning P

    更新日期:2015-01-01 00:00:00

  • Radiotherapy response in head and neck cancer - evaluation of the primary tumour site.

    abstract:CONCLUSION:PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. OBJECTIVES:Assessment of remission at the primary site, in patients treated with organ preservation ther...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.895038

    authors: Sjövall J,Brun E,Almquist H,Kjellén E,Wahlberg P

    更新日期:2014-06-01 00:00:00

  • Strial prostaglandins and leukotrienes. Biochemical characteristics and interrelationship with furosemide.

    abstract::Synthesis of prostaglandins (PGs) was characterized in the lateral wall (LW) of guinea-pig cochlea. Basal synthesis at 37 degrees C was about 480 pg/LW (12.8 ng X mg-1 protein) for PGI2 and 85 pg/LW (2.3 ng X mg-1 protein) for PGE2, levelling out after 10 min of incubation. Incubation with arachidonic acid (10(-5) M) ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Tran Ba Huy P,Ferrary E,Escoubet B,Sterkers O

    更新日期:1987-05-01 00:00:00

  • The vestibular blood flow during CO2-breathing in rabbits.

    abstract::The microsphere method was used to measure the inner ear blood flow in albino rabbits before and during artificial ventilation with 5% CO2 in air. An increase in blood flow resulted in both the cochlear and the vestibular parts of the inner ear. ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709134692

    authors: Larsen HC,Angelborg C

    更新日期:1987-01-01 00:00:00

  • Presence of human papillomavirus in squamous cell laryngeal carcinomas. A study of thirty-nine cases using polymerase chain reaction and in situ hybridization.

    abstract::Human papillomavirus (HPV) has a well-established association with benign and malignant cervical tumours as well as with laryngeal papillomas, while its association with laryngeal carcinomas is still controversial. We have examined 39 squamous cell carcinomas of the larynx for HPV using PCR with three consensus primer...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137949

    authors: Lie ES,Karlsen F,Holm R

    更新日期:1996-11-01 00:00:00

  • Dose and time dependent ototoxicity of aspartame in rats.

    abstract:CONCLUSION:Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased. OBJECTIVES:While Ap toxicity has been stu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1256498

    authors: Ozturan O,Dogan R,Tugrul S,Gedik O,Sjostrand AP,Yildirim YS

    更新日期:2017-04-01 00:00:00

  • Compound action potential and cochlear microphonic extracted from electrocochleographic responses to condensation or rarefaction clicks.

    abstract::In electrocochleography (ECochG) compound action potential (CAP) and summation potential (SP) are usually separated from the cochlear microphonic (CM) by the CM cancellation technique consisting in averaging the responses evoked by rarefaction and condensation clicks. With the aim of analysing the ECochG responses evo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/000164800750000892

    authors: Arslan E,Santarelli R,Sparacino G,Sella G

    更新日期:2000-03-01 00:00:00

  • Post-tonsillectomy haemorrhage: a retrospective comparison of abscess- and elective tonsillectomy.

    abstract:CONCLUSION:There is no increased risk of postoperative haemorrhage for abscess tonsillectomies in comparison to elective tonsillectomies. OBJECTIVE:There is still controversy as regards the optimal management of peritonsillar abscess. Opponents of tonsillectomy à chaud cite an increased postoperative bleeding risk. Mo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480510012336

    authors: Lehnerdt G,Senska K,Jahnke K,Fischer M

    更新日期:2005-12-01 00:00:00

  • Spontaneous otogenic pneumocephalus.

    abstract::The diagnosis and management of spontaneous otogenic pneumocephalus with literature review is described. A young sportsman experienced headache and fluctuating mass in his occiput during increased physical activity. A large extradural intracranial pneumocephalus with corresponding emphysema was imaged on a CT scan. Tr...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.3109/00016489.2010.541941

    authors: Mohammed el R,Profant M

    更新日期:2011-06-01 00:00:00

  • Radix Astragali injection enhances recovery from acute acoustic trauma.

    abstract:CONCLUSION:The average recovery of hearing and cessation of tinnitus was significantly better after treatment with Radix Astragali (RA) than after non-treatment with RA. RA can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT). OBJECTIVES:AAT is one of the early indications for the use of RA. ...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016489.2011.591823

    authors: Xiong M,He Q,Lai H,Huang W,Wang L,Yang C,Wang J

    更新日期:2011-10-01 00:00:00

  • Validity of a new feedback method for the VEMP test.

    abstract:CONCLUSIONS:We used a feedback method, based on a blood pressure manometer with inflatable cuff, to control the sternocleidomastoid muscle (SCM) contraction. To obtain comparable left-right VEMP responses, it is necessary (1) to determine which cuff pressures on both sides yield identical mean rectified voltage (MRV) v...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500527227

    authors: Vanspauwen R,Wuyts FL,Van De Heyning PH

    更新日期:2006-08-01 00:00:00

  • Simultaneous and non-simultaneous dual electrode stimulation in cochlear implants: evidence for two neural response modalities.

    abstract:CONCLUSION:There are two modalities of dual electrode stimulation: a shifting, continuous excitation, which is the desired effect, and a split excitation with considerable variation in loudness. The first one most likely occurs in the basal turn, with adjacent contacts, stimulated simultaneously rather than sequentiall...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802610218

    authors: Frijns JH,Kalkman RK,Vanpoucke FJ,Bongers JS,Briaire JJ

    更新日期:2009-04-01 00:00:00

  • Cuff pressure and microvascular occlusion in the tracheal mucosa. An intravital microscopic study in the rabbit.

    abstract::A method is described for the intravital microscopic observations of rabbit tracheal mucosa microcirculation during compression with a thin, transparent high volume cuff. The cuff pressure (CP) required to cause complete ischemia in the mucosa over the cartilages was measured and a correlation was found to the mean ar...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909137192

    authors: Stenqvist O,Bagge U

    更新日期:1979-01-01 00:00:00

  • The anti-inflammatory effect of erythromycin and its derivatives, with special reference to nasal polyposis and chronic sinusitis.

    abstract::Macrolides have been used for decades as an important chemotherapeutic agent in the treatment of infectious diseases. In the last 10 years there has also been increasing interest in the interaction between macrolide antibiotics and the immune system. The aim of this review is to focus on the anti-inflammatory action o...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/000164801300006326

    authors: Cervin A

    更新日期:2001-01-01 00:00:00

  • Hearing impairment associated with spinal anesthesia.

    abstract:OBJECTIVES:Hearing loss after spinal anesthesia has been reported to be related to the transmission of a reduced subarachnoid pressure to the inner ear via the cochlear aqueduct due to loss of spinal fluid. However, there are also some controversies related to this phenomenon, which require systematic investigation. M...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410017143

    authors: Cosar A,Yetiser S,Sizlan A,Yanarates O,Yildirim A

    更新日期:2004-12-01 00:00:00

  • Aerobic and anaerobic bacteria in chronic suppurative otitis media. A quantitative study.

    abstract::The aerobic and anaerobic bacterial flora of middle ear exudate (MEE) of 47 consecutive patients with chronic suppurative otitis media were studied using a quantitative bacteriological technique under strictly anaerobic conditions. Specimens from the external auditory canal (EAC) and the nasopharynx (NP) were obtained...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609119425

    authors: Jonsson L,Schwan A,Thomander L,Fabian P

    更新日期:1986-11-01 00:00:00

  • Subpixel tracking for the analysis of outer hair cell movements.

    abstract:CONCLUSION:Videomicroscopy with subpixel analysis is an excellent system for quantification of outer hair cell (OHC) movements. The resolution of a few nanometers is accurate enough to show induced differences of electromotility. OBJECTIVE:Electromotility of OHCs is a voltage-dependent process resulting from a membran...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701411502

    authors: Canis M,Ortner M,Olzowy B,Jahn K,Strupp M,Hemmert W,Berghaus A,Suckfuell M

    更新日期:2008-03-01 00:00:00