Abstract:
:Human papillomavirus (HPV) has a well-established association with benign and malignant cervical tumours as well as with laryngeal papillomas, while its association with laryngeal carcinomas is still controversial. We have examined 39 squamous cell carcinomas of the larynx for HPV using PCR with three consensus primers (Cp, My 09/11 and Gp 5+/6+). Specimens positive for consensus primers were examined with specific PCR primers for HPV 6, 11, 16, 18, 31, 33 and 35 and with in situ hybridization (ISH). Three samples (8%) were found HPV positive for two or three consensus primers. One case was confirmed to be HPV 16 with both PCR and ISH. The findings of both a punctate and diffuse signal with the use of ISH indicated HPV to be in both integrated and episomal form. For the other two HPV positive specimens, the examination indicated a type related to HPV 6/11, but it could not be determined with certainty. This study strongly indicates that HPV 16 is associated with some squamous cell laryngeal carcinomas. The possibility of association with other HPV types or mutants of these needs further investigation.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Lie ES,Karlsen F,Holm Rdoi
10.3109/00016489609137949subject
Has Abstractpub_date
1996-11-01 00:00:00pages
900-5issue
6eissn
0001-6489issn
1651-2251journal_volume
116pub_type
杂志文章abstract:CONCLUSION:Endolymphatic hydrops could be a reversible inner ear pathological condition. After sac surgery, hydrops was reduced and symptoms went into remission in some cases, although vertigo suppression was not always a result of the reduced hydrops. OBJECTIVE:To examine the changes in endolymphatic hydrops detected...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.795290
更新日期:2013-09-01 00:00:00
abstract::Sigmoid sinus diverticulum-induced pulsatile tinnitus is a rare medical problem. Here we report a case where pulsatile tinnitus occurred in the perimenopause with evidence of sigmoid sinus diverticulum. The tinnitus disappeared with the restoration of hearing after surgery. While diagnosis is critical for the treatmen...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.567998
更新日期:2011-08-01 00:00:00
abstract::It has previously been shown that simple compounds with multiple amine groups are ototoxic, the degree of ototoxicity depending on the number of amine groups in the molecule. The relationship between the number of amino groups and ototoxicity in aminoglycoside was studied using kanamycin A and kanamycin B, which conta...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709134700
更新日期:1987-01-01 00:00:00
abstract:CONCLUSIONS:We describe a Japanese family with high-frequency sensorineural hearing loss (SNHL) harboring a c.211delC mutation in the KCNQ4 gene. Families showing progressive high-frequency SNHL should be investigated for mutations in the KCNQ4 gene. OBJECTIVE:To determine the responsible deafness gene in a Japanese f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.890740
更新日期:2014-06-01 00:00:00
abstract::An experimental model of sinusitis in the rabbit was developed, using type 3 pneumococci. The superior parts of the rabbit maxillary sinuses were surgically exposed and the maxillary ostium was unilaterally blocked. The following day a challenge dose of 10(7)-10(9) colony-forming units of Streptococcus pneumoniae, cap...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract:CONCLUSIONS:The transconjunctival approach to orbital floor fractures permits excellent exposure of the inferior orbit and provides a good surgical outcome, especially with regard to ocular motility. OBJECTIVE:Surgical access to orbital floor fractures can be accomplished via the transconjunctival approach. The majori...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500395757
更新日期:2006-04-01 00:00:00
abstract:CONCLUSIONS:Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which are essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal epithelial cells. Considering that the ligand for TLR3 is viral dsRNA, this result is in good...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601089416
更新日期:2007-04-01 00:00:00
abstract:CONCLUSION:Mean incudostapedial joint (ISJ) angulation of atretic ears was statistically wider than ISJ angulation of non-atretic ears. Postoperative hearing results in the narrow tympanoplasty type II (T2) subgroup were better than those in the wide T2 subgroup. In cases of abnormally wide ISJ angulation, we recommend...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.552920
更新日期:2011-07-01 00:00:00
abstract:CONCLUSION:The circling mouse (cir/cir) has phenotypes which follow the pattern of neuroepithelial defects of deafness from 10 days after birth. The cir mouse is defective in Tmie gene, the function of which should be further elucidated. OBJECTIVES:We previously reported a recessive mutation of deafness called circlin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600827071
更新日期:2007-03-01 00:00:00
abstract::Eleven patients, who had symptoms of blocking nose in relation to exposure to airway irritants in their work environment, and 11 control subjects recorded nasal and bronchial peak expiratory flow rates (PEFRN and PEFRB) during a working week. In contrast to the control subjects the patients demonstrated a pattern of g...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::Thirty-nine cases of congenital facial asymmetry, in which one corner of the mouth does not dip downward symmetrically with the other, are presented. The author has termed this condition 'congenital unilateral lower lip palsy' (CULLP). CULLP was the most frequent condition in congenital facial anomalies seen in our cl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137173
更新日期:1979-01-01 00:00:00
abstract::We report a case of electromagnetic interference between a bone-anchored hearing aid (BAHA) and a cellular phone. A 54-year-old women was successfully treated for severe mixed conductive and sensorineural hearing loss with a BAHA. Five years after implantation, the patient experienced a sudden feeling of dizziness, ac...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750061723
更新日期:2000-10-01 00:00:00
abstract::During the course of a chronic intracochlear electrical stimulation study using charge balanced biphasic current pulses, one animal inadvertently received a short period of direct current (DC) stimulation at a level of approximately 1 microA. Subsequent, the animal was chronically stimulated using a poorly charge bala...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138421
更新日期:1991-01-01 00:00:00
abstract:CONCLUSIONS:Local administration of MP delivered by the C/GP-MP-hydrogel can improve the recovery of facial nerve following crush injury. The findings suggested that locally injected MP delivered by C/GP-hydrogel might be a promising treatment for facial nerve damage. OBJECTIVES:In this study, the aim is to assess the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::An impaired ostial function may be of importance in the pathogenesis of the maxillary sinus empyema due to changes of the antral gas composition. Oxygen is usually not demonstrable in purulent sinus secretion while carbon dioxide accumulates. In vitro, pneumococci were able to create a similar gas environment, provide...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121431
更新日期:1978-01-01 00:00:00
abstract::This study correlates static and flow-cytometric analysis on paraffin-embedded and fresh material of salivary gland carcinomas. Nuclear suspensions for DNA analysis were prepared from paraffin-embedded and fresh material. Comparison of the results of static and flow cytometry on paraffin-embedded material revealed no ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181080
更新日期:1999-01-01 00:00:00
abstract:CONCLUSION:Endoscopic surgery improved facial pain/headache and physical-psychosocial impacts in patients with nasal polyposis. However, one fifth of patients still experienced residual pain after surgery, requiring neurologic counseling to look for the non-sinonasal cause of their symptoms. OBJECTIVE:Considering the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1058531
更新日期:2015-01-01 00:00:00
abstract::The author presents a study of the personality structure, youth development and the role of interhuman conflicts in the work situation and the family, in the causation and course of Menière's disease, the somatopsychic reactions of the patients to the illness, and the principles of a form of psychotherapy which was co...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139423
更新日期:1983-05-01 00:00:00
abstract::A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128897
更新日期:1982-07-01 00:00:00
abstract:CONCLUSION:An 18-mer peptide derived from the neurotrophic region of prosaposin (PS-pep) prevents hearing loss and cochlear damage due to transient cochlear ischaemia by activating an anti-apoptotic pathway. PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss. OBJECTIVE:PS-pep was inve...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.750430
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS:Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese mu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016489.2017.1296970
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Although community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections have recently become an increasing problem in various fields of medicine, they have rarely been studied in the ear. The purpose of this study was to determine the prevalence of community-acquired MRSA infections in disc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0036554021000028076
更新日期:2002-12-01 00:00:00
abstract:CONCLUSION:The narrowing pattern of the upper airway in obstructive sleep apnea patients may be different in sleep as compared with awake. Three different types of obstruction were observed in these subjects during drug-induced sleep. The different obstruction pattern during drug-induced sleep suggests that different s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480902780242
更新日期:2009-12-01 00:00:00
abstract:CONCLUSION:This study demonstrated that five Cx26 mutations (R32H, S199F, 572delT, 631-632delGT, and Y155X) affect gap junction (GJ) functions by causing impaired membrane targeting and aberrant cellular localization, and one mutation (R165W) leads to a constriction of the channel pore with no dye coupling. OBJECTIVE:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.506885
更新日期:2011-01-01 00:00:00
abstract:CONCLUSIONS:The underlying pathophysiological mechanisms of the posterior nasal nerve (PNN) resection involved the suppression of the secretogogue motor and the inhibition of neurogenic inflammation induced by parasympathetic and sensory denervation. OBJECTIVE:The study was designed to clarify the underlying mechanism...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480801935525
更新日期:2008-01-01 00:00:00
abstract::Critical bandwidths and absolute intensity thresholds were measured in cats before and after kanamycin treatment which induced selective inner and outer hair cell losses. Hair cell losses were measured from cochleograms constructed from surface preparations of the organ of Corti. Results suggested that, for the test f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137179
更新日期:1979-01-01 00:00:00
abstract::In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809124749
更新日期:1978-09-01 00:00:00
abstract::An antimicrobial agent, kanamycin, has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of kanamycin ototoxicity as a function of Rx timing with regard to circadian rhythms. Four groups of comparable weight Sprague-Dawley rats received a daily ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109100749
更新日期:1991-01-01 00:00:00
abstract::The present study further assessed the role of the endolymphatic sac (E.S.) in the generation of inner ear immune responses. Guinea pigs underwent unilateral endolymphatic sac obliteration (Rt) and the opposite ears (Lt) served as controls. The animals were then systemi-cally sensitized to KLII and both inner ears wer...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107782
更新日期:1987-05-01 00:00:00
abstract:CONCLUSION:Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. OBJECTIVES:The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contrib...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480903168066
更新日期:2010-03-01 00:00:00