The role of the endolymphatic sac in inner ear immunity.

Abstract:

:The present study further assessed the role of the endolymphatic sac (E.S.) in the generation of inner ear immune responses. Guinea pigs underwent unilateral endolymphatic sac obliteration (Rt) and the opposite ears (Lt) served as controls. The animals were then systemi-cally sensitized to KLII and both inner ears were subsequently challenged with KLU. Absence of the E.S. significantly reduced perilymph anti-KLH levels and greatly reduced cellular infiltration within the cochlea as compared to the control ears (Lt). Control studies demonstrated that neither surgical trauma to the semicircular canal nor the chemical effects of silver nitrate caused immunosuppression of the normal inner ear immune response. From these findings, the E.S. appears to be the main site of antigen processing in the inner ear and a site analogous to the gut with respect to absorptive and immunologic functions.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Tomiyama S,Harris JP

doi

10.3109/00016488709107782

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

182-8

issue

5-6

eissn

0001-6489

issn

1651-2251

journal_volume

103

pub_type

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