Abstract:
BACKGROUND:Supracricoid partial laryngectomy (SCL) can have a positive impact on patients' quality of life by circumventing dysphagia and voice problems resulting from creation of a permanent stoma after conventional total laryngectomy (TL) surgery. AIMS/OBJECTIVES:The aim of this study was to investigate the oncologic and functional outcomes of salvage SCL for recurrent laryngeal carcinoma. MATERIAL AND METHODS:Forty-five patients that underwent salvage surgery for recurrent laryngeal carcinoma between January 2004 and May 2015 after initial treatment failure were included in this retrospective study. RESULTS:Overall survival and disease free survival were non-significantly higher in the salvage SCL group (n = 14) than in the salvage TL group (n = 31) (87.5 versus 56.5%, 53.4 versus 41.9%). Multivariate analyses showed only positive resection margin to be significantly associated with survival and recurrence (HR 9.974, p = .007, and HR 9.196, p = .002, respectively). In the salvage SCL group, 92.8% achieved successful decannulation and all patients returned to an oral diet. All patients in the salvage TL group sustained a permanent stoma and conversation was possible only through esophageal voice or a voice prosthesis. 74.2% of patients in the group were able to tolerate an oral diet. CONCLUSIONS AND SIGNIFICANCE:Salvage SCL showed comparable oncologic outcomes and favorable functional outcomes relative to the classic salvage TL. This study could provide a sufficient basis of SCL as salvage treatment for recurrent laryngeal carcinoma in selected patients.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Kim JH,Kim WS,Koh YW,Kim SH,Byeon HK,Choi ECdoi
10.1080/00016489.2018.1506154subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1117-1122issue
12eissn
0001-6489issn
1651-2251journal_volume
138pub_type
杂志文章abstract::The early development of human otoconial membranes was studied by scanning electron microscopy and X-ray microanalysis; 87 specimens, ranging from 7 to 12 weeks gestational age were examined. A few otoconia, which contained calcium, were present in the utricle by the end of the seventh week. By 8 weeks, both the saccu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128884
更新日期:1982-07-01 00:00:00
abstract::The change in the EP, CM, SP and AP during perilymphatic perfusion of vasopressin (antidiuretic hormone) was examined in the guinea pig. The EP was recorded with a microelectrode through the spiral ligament of the second turn. The CM, SP and AP were measured with the differential electrodes in the basal turn. The perf...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609132830
更新日期:1986-03-01 00:00:00
abstract:CONCLUSIONS:It has been shown that TRPMs may play a functional role in sensory cell physiology, fluid homeostasis, sensory cell death, and thermosensation in the inner ear, while TRPA1 plays an important role in sensory transduction. OBJECTIVE:To study expression of TRPM1-8 and TRPA1 in the mouse inner ear. MATERIALS...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802570545
更新日期:2009-10-01 00:00:00
abstract::The sympathetic nerve pathways to the nasal vasculature were examined in 8 cats by recoding the effects of section of the orbital nerves on vasoconstriction produced by cervical sympathetic nerve stimulation. No sympathetic fibres were found in the sphenopalatine and infraorbital nerves. The majority were conveyed by ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709123967
更新日期:1977-09-01 00:00:00
abstract::The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external caro...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097018
更新日期:1988-03-01 00:00:00
abstract::Nl action potentials, elicited by low-level, 4.0-kHz filtered clicks, were recorded from the ear canals of normal-hearing adults. Responses were recorded at two sensation levels in the presence and absence of a pure tone delivered to the contralateral ear. Waveforms were analysed for changes in amplitude and latency. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107792
更新日期:1987-05-01 00:00:00
abstract:CONCLUSION:MCT is a useful tool to pre-operatively determine whether internal nasal valve (INV) narrowing affects a nasal obstruction. Functional rhinoplasty seemed to produce better results than septoplasty in Asian patients with a nasal obstruction, due to INV narrowing. OBJECTIVE:This study compared pre-operative m...
journal_title:Acta oto-laryngologica
pub_type: 评论,杂志文章
doi:10.3109/00016489.2015.1108523
更新日期:2016-01-01 00:00:00
abstract:CONCLUSION:Although this study did not show higher risk of oropharyngeal malignancy in HIV patients overall, they still had much higher prevalence of NHL as well as HL than HIV negative patients. Presence of cervical lymphadenopathy is unreliable in differentiating malignant oropharyngeal tumours from benign lymphoid h...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2016.1170878
更新日期:2016-09-01 00:00:00
abstract::Serially cultivated rat middle ear epithelium was studied under exposure to various concentrations of carbon dioxide. Three experiments were performed exposing the epithelium to a gaseous environment containing 5 or 10% CO2 or to an atmosphere almost devoid of CO2. Oxygen was maintained constant at 20% and nitrogen wa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009125165
更新日期:1990-05-01 00:00:00
abstract::The influence of neck and leg proprioceptive inputs on optokinetic-induced quick phases was studied in humans. Ten subjects received unidirectional horizontal optokinetic stimulation (10-20%/s) during sinusoidal neck, leg and combined neck + leg proprioceptive stimulation. The optokinetic reflex was measured by electr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043523
更新日期:2001-01-01 00:00:00
abstract:CONCLUSION:Early intervention may change the natural course of allergic rhinitis, preventing the progression to asthma. In particular, immunotherapy guarantees remission of local symptoms and valid protection against local and bronchial complications. Symptomatic treatment represents a valid alternative; it is always t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.815362
更新日期:2013-11-01 00:00:00
abstract::This study was designed to investigate morphological changes in the tympanic membrane (TM) associated with cholesteatoma formation in experimental animals following application of propylene glycol to the middle ear. A 50% solution of propylene glycol was applied bilaterally to the middle ear cavities of 30 young-adult...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909107401
更新日期:1989-07-01 00:00:00
abstract::This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent e...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750045983
更新日期:2000-06-01 00:00:00
abstract::The sound conduction method for measurement of the Eustachian tube opening has been studied and modifications made in the test procedure to increase its easy performance and reliability. By holding the sound source near to the nostril, mounting the microphone into a circumaural ear defender and by feeding the output o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809124724
更新日期:1978-07-01 00:00:00
abstract:CONCLUSIONS:The critical stage for cochlear gene regulation in the embryo is E49-E56. These data provide a valuable resource to help elucidate gene regulation in cochlear development and will benefit ear-related studies, especially those that focus on gene and stem cell therapies in hearing loss. OBJECTIVES:To investi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1341641
更新日期:2017-11-01 00:00:00
abstract::Patients with Bell's palsy were investigated with regard to the cellular immune response during the acute and convalescent stages with the purpose of acquiring information concerning the etiology of the condition. In order to ascertain whether there was activation of the immune system, the proportion of activated T ce...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119452
更新日期:1988-01-01 00:00:00
abstract:CONCLUSION:Telephone usage is a difficult challenge for cochlear implanted patients. A significant number of cochlear implanted patients are able to carry on a land-line or mobile telephone conversation. The telephone model may be a critical factor for telephone performance. OBJECTIVES:The goals of this study were to ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500469552
更新日期:2006-07-01 00:00:00
abstract:CONCLUSION:Alterations within a novel putative Exon 1a within the gap junction beta 2 (GJB2) gene may play a role in the development of genetic hearing impairment in Austria. OBJECTIVES:Mutations in the GJB2 gene are the most common cause of hereditary sensorineural deafness. Genome-wide screening for alternative tran...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1249946
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Li quick repositioning maneuver for treatment of geotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV) was reported in the literature. OBJECTIVE:The aim of this study is to observe the clinical efficacy of the Li quick repositioning maneuver for the treatment of geotropic HC-BPPV. METHO...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
abstract:CONCLUSION:The chewing gum indirectly affects postural control by influencing vestibular function to stabilize posture during upright standing. OBJECTIVES:This study aimed to evaluate the effect of chewing gum on static posturography in patients. METHODS:The subjects were 26 patients with chronic balance disorders. T...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016489.2011.607846
更新日期:2011-11-01 00:00:00
abstract::By using the microsuction technique, quantitative determination of the chemical mediators in nasal secretions was performed in 40 patients with seasonal allergic rhinitis during the pollen season. The aim of this study was to investigate the actual concentrations of these important mediators in nasal secretions during...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126103
更新日期:1994-09-01 00:00:00
abstract::Cochlear blood flow in guinea pigs was assessed using histological assessment of various red blood cell and vessel lumen parameters. Cochlear blood flow was either enhanced by administration of carbogen or inhibited by induced positive airway pressure. The resulting enhancement or reduction of blood flow in the cochle...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709109055
更新日期:1987-07-01 00:00:00
abstract::Background: Amyloidosis is a benign, slowly progressive disease. However, the treatment of laryngeal amyloidosis (LA) has not been studied systematically.Objectives: To investigate the treatment results of cold micro forceps or carbon dioxide laser under microlaryngoscope in the treatment of LA.Methods: A retrospectiv...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1680864
更新日期:2019-12-01 00:00:00
abstract::The purpose of this study was to show the early stages of polyp formation, as part of our studies on the pathogenesis of nasal polyps. Two and 4 weeks after experimental tubal occlusion in 18 Wistar rats, 13 showed signs of bacterial infection, respective acute otitis media. In the majority of these rats polypouslike ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138432
更新日期:1991-01-01 00:00:00
abstract::The subjective visual horizontal (SVH) was measured by means of a small, rotatable, luminous line in darkness in the upright head and body position and at 10, 20 and 30 degrees of tilt to the right and left before, and repeatedly during a follow-up period of 1 year after intratympanic gentamicin instillations in 12 pa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850154595
更新日期:1998-07-01 00:00:00
abstract::A delayed conditioning paradigm was employed to condition the stapedius muscle. While many previous attempts have failed using loud sound as the unconditioned stimulus(UCS), this paper presents evidence of successful conditioning of this muscle when the unconditioned stimulus was a mild electrocutaneous stimulation of...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016487609120857
更新日期:1976-07-01 00:00:00
abstract::The aim of this study was to evaluate histologic changes after long-term administration of the topical nasal decongestants phenylephrine and oxymetazoline. Ninety healthy rabbits were divided into 3 groups for topical administration for 1 week, 2 weeks, and 4 weeks. Each group was subdivided into 3 subgroups by topica...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139384
更新日期:1995-09-01 00:00:00
abstract::Ionic mechanisms sustaining sensory transduction in crista ampullaris sensory cells have been investigated chiefly by replacing the endolymph with solutions with K+ and Ca++ chelators added. The effects of the modified solutions were evaluated by extracellular and intracellular recordings of both and the presynaptic a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130893
更新日期:1982-05-01 00:00:00
abstract:CONCLUSION:The results of this study give support to the theory that opening the middle ear (ME) to the atmosphere leads to a deterioration in its pressure regulation capacity. However, this is probably not the reason why a perforation of the tympanic membrane becomes chronic. OBJECTIVE:Direct, continuous measurement ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510029374
更新日期:2005-07-01 00:00:00
abstract::We report the case of a young male patient with ankylosing spondylitis treated with sulphasalazine who developed bilateral sensorineural hearing loss with tinnitus. Discontinuation of sulphasalazine led to complete resolution of tinnitus and an improvement in hearing loss. We discuss the features of this case and also...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/00016480510026962
更新日期:2005-06-01 00:00:00