Abstract:
:This study was designed to investigate morphological changes in the tympanic membrane (TM) associated with cholesteatoma formation in experimental animals following application of propylene glycol to the middle ear. A 50% solution of propylene glycol was applied bilaterally to the middle ear cavities of 30 young-adult chinchillas. The animals were sacrificed for light and electron microscopic study at intervals of 2 days to 6 weeks after a single application of 0.2 ml of the propylene glycol solution. At 2 days there was complete destruction of the epidermal and mucosal layers of the TM. The denuded lateral surface rapidly became re-epithelialized by hyperplastic epidermal cells and by 2-3 weeks, keratinizing epidermis penetrated damaged areas of the fibrous layer of the lamina propria to reach the medial surface of the TM. These epidermal cells proliferated in the middle ear cavity, forming cholesteatomas. Our observations indicate that invasion of the intact, but structurally altered, tympanic membrane by hyperplastic epidermis is a primary mechanism of cholesteatoma formation in the animal model.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Masaki M,Wright CG,Lee DH,Meyerhoff WLdoi
10.3109/00016488909107401subject
Has Abstractpub_date
1989-07-01 00:00:00pages
113-21issue
1-2eissn
0001-6489issn
1651-2251journal_volume
108pub_type
杂志文章abstract:CONCLUSION:After conventional curette adenoidectomy, a significant mass of residual adenoid tissue is observed in about 50% of the cases. The combined approach of conventional curette and endoscopic adenoidectomy with microdebrider assures a complete and accurate removal of the mass. It is an effective and safe method ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802294377
更新日期:2009-05-01 00:00:00
abstract:CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500395179
更新日期:2006-12-01 00:00:00
abstract::In previous studies, sinus secretions have been analysed concerning pO2, pCO2 and pH. In this study the energy metabolism in the maxillary sinus mucosa and secretion was studied in 33 New Zealand White rabbits. In freeze-dried samples, glucose and lactate were analysed by enzymatic assays and ATP by HPLC. In the purul...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809122271
更新日期:1988-11-01 00:00:00
abstract::To elucidate immune mechanisms in otitis media, middle ear infection was induced in 12 rats by intratympanic inoculation of Streptococcus pneumoniae type 3, either the ipsilateral or the contralateral middle ear being re-challenged 4 weeks later. Otomicroscopy inspection confirmed the presence of acute otitis media (A...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109100760
更新日期:1991-01-01 00:00:00
abstract::Microsurgery of the facial nerve has resulted in a great progress by regaining, thanks to its various techniques, not only the voluntary movements of the face but in addition also the emotional expressive motility. It has become evident, however, that one disadvantage is always unavoidable even in the most subtle reco...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109138533
更新日期:1981-05-01 00:00:00
abstract:CONCLUSION:Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. OBJECTIVE:Prognostic f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480802642096
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To ascertain whether a daily nasal spray with physiological saline could prevent symptoms of common cold in a population of otherwise healthy adults. MATERIAL AND METHODS:This was study involving 10 weeks of daily use of a nasal saline spray and 10 weeks of only recording symptoms. Young adults eligible for ...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/00016480410017657
更新日期:2004-11-01 00:00:00
abstract::In electrocochleography (ECochG) compound action potential (CAP) and summation potential (SP) are usually separated from the cochlear microphonic (CM) by the CM cancellation technique consisting in averaging the responses evoked by rarefaction and condensation clicks. With the aim of analysing the ECochG responses evo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000892
更新日期:2000-03-01 00:00:00
abstract::Upper airway symptoms are common, but there is little information available on clinical findings in relation to indoor air pollution. This pilot study was conducted to test whether increased levels of indoor air pollutants in schools may correlate to a swelling of the nasal mucosa. The assumption was made that the deg...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113467
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To report on the long-term results, focusing on prosthesis lifetime, achieved with the VoiceMaster prosthesis in an outpatient population. MATERIAL AND METHODS:The VoiceMaster prosthesis was used over a 40-month period. Average prosthesis lifetimes were calculated both individually and for the group as a who...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001330
更新日期:2003-06-01 00:00:00
abstract::Most epidemiological surveys concerning populations exposed to occupational noise or random populations have shown that the left ear is slightly but significantly poorer than the right ear, especially at frequencies most susceptible to noise damage. To experimentally study the possible left-right asymmetry in response...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138399
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To investigate pathological gait in patients with unilateral acoustic neuroma using tactile sensors placed under both feet. MATERIAL AND METHODS:Forty-three patients were enrolled in the study. They were categorized into two groups: the small tumor group had tumors < 2 cm from the porus acousticus without an...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310000566
更新日期:2004-05-01 00:00:00
abstract::Background: Amyloidosis is a benign, slowly progressive disease. However, the treatment of laryngeal amyloidosis (LA) has not been studied systematically.Objectives: To investigate the treatment results of cold micro forceps or carbon dioxide laser under microlaryngoscope in the treatment of LA.Methods: A retrospectiv...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1680864
更新日期:2019-12-01 00:00:00
abstract:CONCLUSIONS:The results of this study confirm that both smoking of tobacco and alcohol consumption are risk factors for oral and oropharyngeal squamous cell carcinoma (OOSCC). The use of moist snuff had no effect on the risk of OOSCC, probably due to the low levels of tobacco-specific N-nitrosamines in Swedish moist sn...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510043440
更新日期:2005-09-01 00:00:00
abstract::On-line measurement of ME gas composition in normal middle ears of 5 anesthetized guinea pigs at an established steady state was performed by mass spectrometry. The mean values for the gas composition of the middle ear were found to be: PN2: 82.4%, PO2: 7.6% and PCO2: 10.0%. This composition is very different from tha...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135824
更新日期:1993-05-01 00:00:00
abstract::A questionnaire was devised to quantify and measure four categories: the behavioral characteristics of Type A, self-restraint and escape; the causes of anxiety; means of relaxation; and symptoms incidental to anxiety. Questionnaire analysis was performed in patients (n = 60) with Meniere's disease and in a control pop...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043721
更新日期:2001-01-01 00:00:00
abstract::Aspartate and alanine aminotransferase (ASAT, ALAT) activities were measured in human post-mortem sera, cerebrospinal fluid (CSF), perilymph and endolymph. Due to heart and/or liver morbidity during a terminal illness, the ASAT and ALAT serum activities were considerably increased as compared with normal and both were...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609107478
更新日期:1976-01-01 00:00:00
abstract::Background: Intratympanic and intravenous gadolinium administration is used to visualise endolymphatic hydrops. Aims/objectives: The goal of this study was to compare the image quality between intratympanic (IT-method) and intravenous (IV-method) gadolinium administration using three-dimensional inversion recovery wit...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016489.2019.1600719
更新日期:2019-08-01 00:00:00
abstract::The distribution of vascular endothelial growth factor (VEGF), one of the most important angiogenic factors, and microvessel density (MVD) were assessed in laryngeal carcinomas by means of immunohistochemistry. Correlation of VEGF with MVD and clinical parameters (T stage, N stage, histological grading, survival, recu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180711
更新日期:1999-01-01 00:00:00
abstract:CONCLUSION:A very low dose of dexamethasone (DEX) was as equally as sufficient as a pharmacological dose to decrease eosinophil inflammation in airways and bone marrow. The timing of DEX treatment in relation to allergen challenge was strongly decisive for the outcome of the inflammatory response. OBJECTIVES:We aimed ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802126561
更新日期:2009-02-01 00:00:00
abstract:CONCLUSION:Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/00016481003629036
更新日期:2010-09-01 00:00:00
abstract:CONCLUSIONS:Thorough otomicroscopical examination of the tympanic membrane in acute otitis media (AOM) might distinguish AOM episodes caused by different bacteria. It thus might be a way to select appropriate treatment for each patient without raising the number of dangerous complications. OBJECTIVES:The aim of this s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601091719
更新日期:2007-09-01 00:00:00
abstract::Three hundred and fifty-four patients with squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx, hypopharynx or maxillary sinus have been randomized for preoperative radiation therapy and surgery versus surgery and postoperative radiation therapy plus, in the case of patients with lesions of the...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016488109138548
更新日期:1981-05-01 00:00:00
abstract:INTRODUCTION:CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall poor prognosis, also due to early spread of metastatic cells. MATERIALS AND METHODS:Tumor and l...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1378436
更新日期:2018-02-01 00:00:00
abstract::Observations of Hallpike (1967) suggested that the neural mechanism responsible for positional nystagmus of central type, the direction-changing type of Nylén, was dependent upon derangement of compensatory eye reflexes subserved by neck proprioceptors and/or otolith organs in the presence of damage to the medial vest...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139447
更新日期:1983-05-01 00:00:00
abstract::The effect of the extracellular calcium concentration on serially cultured rat middle ear epithelium was investigated with phase contrast microscopy, scanning electron microscopy, and transmission electron microscopy, as well as by a method to induce cornified envelope formation with a calcium ionophore. The results s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009107420
更新日期:1990-01-01 00:00:00
abstract:CONCLUSION:The use of both gadolinium chloride (GdCl(3)) and osmium tetroxide (OsO(4)) allowed for the visualization of the membranous labyrinth and other intralabyrinthine structures, at different intensities, as compared with the control sample. This initial comparison shows the advantages of GdCl(3) in radiological ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.715751
更新日期:2013-01-01 00:00:00
abstract::Seven to eight years after a disease period of vestibular neuritis 19 patients previously examined at our department were given a questionnaire about whether they had experienced any audiovestibular symptoms since they first fell ill. All 19 patients responded and 18 consented to participate in the long-term follow-up...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180243
更新日期:1999-01-01 00:00:00
abstract:CONCLUSION:The approach described in this paper may be helpful in establishing an early-warning, evidence-based mechanism for diagnosing vertigo, which can be utilized in medical education to reduce medical uncertainty. OBJECTIVE:To use an evidence-based medicine approach to evaluate the probability of having vertigo ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510043468
更新日期:2006-01-01 00:00:00
abstract::Patients with chronic otitis media (COM) were divided into two groups, one to be given Cephalexin (CEX) orally and the other to be given CEX ear drops locally. The counts of viable bacteria in otorrheal samples collected before and after CEX administration were determined. The incidence of decrease in the count of bac...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133264
更新日期:1981-09-01 00:00:00