Auditory epithelial migration. II: Morphological evidence for auditory epidermal cell migration in rat.

Abstract:

:Morphology of the tympanic membrane (TM) and external auditory canal (EAC) was studied in healthy, intact rat ears. TM-perforated ears (3 days after making the perforation) and TM-perforation-healed ears (14, 28 and 42 days after making the perforation). In intact ears, the epidermis in the annular region of the EAC displayed a characteristic appearance with cytoplasmic protrusions. We termed these protrusions as "finger-like projections". In contrast to the rat, the annular region of the EAC in the guinea-pig did not show "finger-like projections". Following a perforation in the centre of the anterior or the posterior quadrant of the pars tensa in rats the "finger-like projections" disappeared from the annular region on the perforated side of the EAC, while the projections remained on the malleus side of the perforation edge. In perforation-healed ears analysed 42 days after the perforation, the "finger-like projections" had recurred in the annular region on the perforated side of the EAC. The "finger-like projections" are likely to express maturation (keratinization) and desquamation of epidermal cells in the pars tensa and also could constitute morphological evidence of their migration on the TM.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Kakoi H,Anniko M

doi

10.3109/00016489609137939

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

850-3

issue

6

eissn

0001-6489

issn

1651-2251

journal_volume

116

pub_type

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