The release of histamine from the pars flaccida mast cells one cause of otitis media with effusion?

Abstract:

:In this experimental study in the rat, compound 48/80--a potent degranulating drug of mast cells--was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympanic bulla. Both these procedures caused a degranulation of the pars flaccida mast cells and subsequently histamine was detected in the rinsing fluid collected from the middle ear cavity. A possible direct cause of the effusion material in the middle ear cavity may be a degranulation of the pars flaccida mast cells, thus resembling an allergic reaction Type I.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Alm PE,Bloom GD,Hellström S,Salén B,Stenfors LE

doi

10.3109/00016488209128942

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

517-22

issue

5-6

eissn

0001-6489

issn

1651-2251

journal_volume

94

pub_type

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