Neurophysiological indices of language impairment in children.

Abstract:

:Recent investigations of children with specific language impairment (SLI) have found deviant anatomical asymmetry of the perisylvian cortex. These studies argue that this deviant anatomical asymmetry is linked to the language disorders of SLI children. To date no studies have examined whether deviant functional asymmetry underlies the processing of spoken language in these children. In the current study, brain-electrical activity was recorded from 31 scalp sites while children with SLI listened to auditorally presented stories and two different nonsense contexts. Electrical activity was time-locked to the grammatical word "the" in these contexts. The SLI children showed reversed asymmetry compared to control children from 200 ms to 400 ms in processing "the" in all contexts. More specifically, they showed depressed processing at the left temporal scalp site (T7) and enhanced processing at the right temporal site (T8). The second spatial derivative (the Laplacian) of the voltage activity was calculated to remove constant voltage potential and uniform changes in voltage potential across the scalp. The Laplacian analysis indicated that the sources of the positive electrical activity seen at the temporal electrode sites T7 and T8 are the lateral surfaces of the temporal cortices. A comparison of the scalp topography of the voltage potentials and Laplacian also suggests that children with SLI lack some contribution from a deep neural generator, possibly in the hippocampus or basal ganglia. This investigation is the first to demonstrate a direct link between deviant neurophysiological asymmetry and the processing of spoken language in children with SLI.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Shafer VL,Schwartz RG,Mor ML,Kessler KL,Kurtzberg D,Ruben RJ

doi

10.1080/000164801300043929

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

297-300

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

121

pub_type

杂志文章
  • Basic mechanisms in autonomic nervous responses in specific and nonspecific nasal hyperreactivity.

    abstract::The nasal mucosa and the autonomic nervous regulation of protective reflexes plays an important role for the protection of the lower airways. Increasing experimental evidence from both animal models and humans suggests that the organization of the autonomic nervous pathways is more complicated than previously assumed....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.3109/00016489309135832

    authors: Anggård A

    更新日期:1993-05-01 00:00:00

  • Neuronal habituation in the vestibular nuclei of the cat.

    abstract::This is a study of the effects of repeated angular acceleration on the activity of vestibular nuclei units in anesthetized and in conscious cats. The experimental animals were subjected to trains of repeated and consecutive constant acceleration-deceleration ramps (4-8 degrees/sec2). In a few cases nystagmus was recor...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009131713

    authors: Kileny P,Ryu JH,McCabe BF,Abbas PJ

    更新日期:1980-09-01 00:00:00

  • Intermediate filament proteins in the embryonic inner ear of mice under normal conditions and after exposure to ototoxic drugs.

    abstract::The expression of the intermediate filament subclasses cytokeratins (CKs), vimentin, and neurofilament triplet proteins (NFs) was analysed in the embryonic inner ear of the CBA/CBA mouse, in vivo and in vitro, using well-defined monoclonal antibodies. Some of the cultured inner ears were exposed to 1-10 micrograms/ml ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489009107415

    authors: Berggren D,Anniko M,Thornell LE,Ramaekers FC,Virtanen I

    更新日期:1990-01-01 00:00:00

  • T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy.

    abstract::In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135796

    authors: Tennvall J,Wennerberg J,Willén R,Ask A,Baldetorp B,Fernö M

    更新日期:1993-03-01 00:00:00

  • Olfactory dysfunction in patients after recovering from COVID-19.

    abstract:BACKGROUND:Smell and taste disorders occur in COVID-19 with a high prevalence, but little is known about the duration of the symptoms. In particular, studies using validated olfactory tests are very rare to date. AIMS/OBJECTIVES:The aim of this study was to determine the olfactory function of COVID-19 recoveries by a ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1811999

    authors: Otte MS,Eckel HNC,Poluschkin L,Klussmann JP,Luers JC

    更新日期:2020-12-01 00:00:00

  • Pilot study of a device for measuring instrument forces during endoscopic sinus surgery.

    abstract::ESS is a form of minimal access surgery that includes different tasks and manoeuvres requiring sophisticated psychomotor coordination with varying levels of force application. The avoidance of complications is partially dependent upon reducing surgical force application when operating against vital barriers such as th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016568

    authors: White PS,Nassif R,Saleh H,Drew T

    更新日期:2004-03-01 00:00:00

  • Experimental acute sinusitis in rabbit. A study of mucosal blood flow.

    abstract::An experimental model of sinusitis in the rabbit was developed, using type 3 pneumococci. The superior parts of the rabbit maxillary sinuses were surgically exposed and the maxillary ostium was unilaterally blocked. The following day a challenge dose of 10(7)-10(9) colony-forming units of Streptococcus pneumoniae, cap...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Drettner B,Johansson P,Kumlien J

    更新日期:1987-05-01 00:00:00

  • Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig.

    abstract::Reserpine (2 mg/kg and 10 mg/kg, i.p.), an adrenergic blocker, was administered to normal guinea pigs, and samples of serum, CSF, scala tympani perilymph, scala vestibuli perilymph and cochlear endolymph were collected. The concentrations of Na and K in these fluids were then assessed to observe electrolyte distributi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409107540

    authors: Kanoh N,Makimoto K

    更新日期:1984-07-01 00:00:00

  • Partial deafness cochlear implantation provides benefit to a new population of individuals with hearing loss.

    abstract:CONCLUSION:Partial deafness cochlear implantation (PDCI) is a feasible means of treating individuals who have good low frequency hearing, but a severe to profound hearing loss in the mid to high frequencies. The individuals have benefit in noise and show significant benefit in a number of difficult listening conditions...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480600606632

    authors: Skarzynski H,Lorens A,Piotrowska A,Anderson I

    更新日期:2006-09-01 00:00:00

  • Surgical methods and postoperative results of cochlear implantation in 79 cases of ossified cochlea.

    abstract:CONCLUSION:A man-made bone tunnel of 1.5 turns around the modiolus can be created in cases of total cochlear ossification. Patients with ossified cochlea types I and II achieved satisfactory hearing results after cochlear implantation (CI). Patients with ossified cochlea type III, in which the modiolus is damaged by th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.947656

    authors: Wang L,Zhang D

    更新日期:2014-12-01 00:00:00

  • Experimental surgery on the nose. I. Airflow and goblet-cell density.

    abstract::In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487809124749

    authors: Mogensen C,Tos M

    更新日期:1978-09-01 00:00:00

  • Electrocochleography and cochlear pathology.

    abstract::In experimentally damaged inner ears the structural alterations were correlated to electrocochleographic responses of the ear. Sectioning of the cochlear nerve with degeneration of the type I neurons but intact sensory cells results in normal cochlear microphonics but very weak and atypical nerve responses. By contras...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709128822

    authors: Spoendlin H,Baumgartner H

    更新日期:1977-01-01 00:00:00

  • Low serum folate levels: a risk factor for sudden sensorineural hearing loss?

    abstract:OBJECTIVE:Ischemic vascular damage of the inner ear is one of the known causes of sensorineural sudden hearing loss (SSHL). Folate is an emerging risk factor associated with an increased risk of vascular damage. The aim of this study was to investigate whether low serum folate levels are associated with SSHL. MATERIAL...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016216

    authors: Cadoni G,Agostino S,Scipione S,Galli J

    更新日期:2004-06-01 00:00:00

  • On the Limited Transfer of Information with Noise-induced Hearing Loss.

    abstract::Assessment of hearing handicap is frequently based on hearing loss in the frequency region from 0.5 to 2.0 kHz. The region above 2 kHz, however, is important for hearing, particularly when one considers speech perception in conditions with ambient noise. The present study, based on 200 individuals (400 ears) with nois...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.1990.12088407

    authors: Smoorenburg GF

    更新日期:1990-01-01 00:00:00

  • Effects of short inter-stimulus intervals on olfactory and trigeminal event-related potentials.

    abstract:CONCLUSION:Chemosensory event-related potentials (CSERPs) were identified in all measurements using the 20 s and the 10 s inter-stimulus interval (ISI) protocol, reducing the recording time to 75% or 57% compared with the standard protocol. A possible explanation for the rising CSERP amplitudes by shortening the ISI in...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480802644605

    authors: Kassab A,Schaub F,Vent J,Hüttenbrink KB,Damm M

    更新日期:2009-11-01 00:00:00

  • Effect of glycerol on electrochemical composition of endolymph and perilymph in the rat.

    abstract::Glycerol (2 g/kg body weight), or 0.15 M NaCl for control animals, was administered to rats by i.v. injection. The dose was chosen in order to obtain an osmolarity increase in plasma of about 15 mosm/l 1 h after the glycerol administration, an increase which is similar to that observed in the human glycerol dehydratio...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137887

    authors: Morrison GA,Teixeira M,Sterkers O,Amiel C,Ferrary E

    更新日期:1996-07-01 00:00:00

  • The role of local gas composition in pathogenesis of maxillary sinus empyema.

    abstract::An impaired ostial function may be of importance in the pathogenesis of the maxillary sinus empyema due to changes of the antral gas composition. Oxygen is usually not demonstrable in purulent sinus secretion while carbon dioxide accumulates. In vitro, pneumococci were able to create a similar gas environment, provide...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487809121431

    authors: Carenfelt C,Lundberg C

    更新日期:1978-01-01 00:00:00

  • Photographic studies of the larynx in central laryngeal paresis and paralysis.

    abstract::Characteristic patterns of laryngeal dysfunction due to central neurologic disease are documented by 16 mm ciné photography. Representative patients are used to describe typical patterns of abnormal laryngeal function which occur in upper motor neuron, extrapyramidal, cerebellar, nuclear and mixed foci of lesions. The...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488109138516

    authors: Ward PH,Hanson DG,Berci G

    更新日期:1981-05-01 00:00:00

  • Breathing disorders in sleep associated with "microarousals' in patients with allergic rhinitis.

    abstract::The influence of obstructed nasal passages was investigated in l4 patients with allergic rhinitis. Disordered breathing in sleep was found in all patients in the form of periodic breathing, and hypopneic and hyperpneic episodes, associated with characteristic "microarousals' from sleep. Patients had an average of 50 "...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488109133292

    authors: Lavie P,Gertner R,Zomer J,Podoshin L

    更新日期:1981-11-01 00:00:00

  • The hearing aid revolution: fact or fiction?

    abstract:OBJECTIVE:To present the experiences of consumers with traditional hearing aids (T-HAs) and digital signal processing hearing aids (DSP-HAs) during the period 1999-2001, based on data obtained from an ongoing quality assurance programme. MATERIAL AND METHODS:A questionnaire is mailed to subjects fitted with HAs 3-4 mo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480310001088

    authors: Parving A

    更新日期:2003-01-01 00:00:00

  • HITCal: a software tool for analysis of video head impulse test responses.

    abstract:CONCLUSION:The developed software (HITCal) may be a useful tool in the analysis and measurement of the saccadic video head impulse test (vHIT) responses and with the experience obtained during its use the authors suggest that HITCal is an excellent method for enhanced exploration of vHIT outputs. OBJECTIVE:To develop ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1035401

    authors: Rey-Martinez J,Batuecas-Caletrio A,Matiño E,Perez Fernandez N

    更新日期:2015-09-01 00:00:00

  • Sleep-related deglutition in patients with OSAHS under CPAP therapy.

    abstract:CONCLUSION:Continuous positive airway pressure (CPAP) therapy improved not only apnea-hypopnea during sleep and sleep structure but also sleep-related deglutition, especially respiratory phase patterns associated with deglutition. OBJECTIVES:Sleep-related deglutition and related respiratory phase patterns in patients ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.520166

    authors: Sato K,Umeno H,Chitose S,Nakashima T

    更新日期:2011-02-01 00:00:00

  • Immunohistological analysis of eotaxin and RANTES in the model animal of eosinophilic otitis media.

    abstract:BACKGROUND:The most crucial clinical problem of Eosinophilic Otitis Media (EOM) is sensorineural hearing loss. A previous report revealed that repeated antigen stimulation of middle ear causes eosinophilic inflammation not only in the middle ear but also in the inner ear. OBJECTIVE:The purpose of the present study was...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1266508

    authors: Kudo N,Matsubara A,Nishizawa H,Miura T

    更新日期:2017-05-01 00:00:00

  • Postnatal development of the auditory evoked brainstem potentials in the guinea pig.

    abstract::The postnatal development of lower stations in the auditory pathway was studied in the guinea pig by recording auditory brainstem potentials. At birth, the brainstem responses of young guinea pigs already have thresholds corresponding to those of adult animals. However, the latencies of the individual potentials are s...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409130965

    authors: Dum N

    更新日期:1984-01-01 00:00:00

  • Acoustic stapedius muscle reflex in mercury-exposed Andean children and adults.

    abstract:CONCLUSION:The results suggested mercury (Hg)-induced anomalies in the brainstem-mediated acoustic stapedius muscle reflex in children. OBJECTIVES:Hg exposure has been associated with hearing impairment and brainstem anomalies. Acoustic stapedius reflex (ASR) thresholds, growth functions, decay/adaptation times, and b...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.617778

    authors: Counter SA,Buchanan LH,Ortega F

    更新日期:2012-01-01 00:00:00

  • Over-adduction of the unaffected vocal fold during phonation in the unilaterally paralyzed larynx.

    abstract:CONCLUSIONS:Over-adduction of the unaffected vocal fold may not compensate vocal function in unilateral vocal fold paralysis (UVFP). OBJECTIVE:To determine whether over-adduction of the unaffected vocal fold has any impact on vocal function in patients with UVFP. METHODS:A total of 101 patients with UVFP who underwen...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.886020

    authors: Yumoto E,Sanuki T,Minoda R,Kumai Y,Nishimoto K,Kodama N

    更新日期:2014-07-01 00:00:00

  • Long-term results of VoiceMaster voice prosthesis use in laryngectomized patients.

    abstract:OBJECTIVE:To report on the long-term results, focusing on prosthesis lifetime, achieved with the VoiceMaster prosthesis in an outpatient population. MATERIAL AND METHODS:The VoiceMaster prosthesis was used over a 40-month period. Average prosthesis lifetimes were calculated both individually and for the group as a who...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480310001330

    authors: Eerenstein SE,Schouwenburg PF

    更新日期:2003-06-01 00:00:00

  • Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise.

    abstract:CONCLUSION:The results suggest that the beneficial effect of astragaloside IV on impulse noise-induced hearing loss may be due to its ability to inhibit reactive oxygen species (ROS) and prevent apoptosis. OBJECTIVE:Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.643457

    authors: Xiong M,He Q,Lai H,Wang J

    更新日期:2012-05-01 00:00:00

  • Elevated levels of myelin basic protein in CSF in relation to auditory brainstem responses in Bell's palsy.

    abstract::Myelin basic protein (MBP) in the cerebrospinal fluid (CSF) was quantified from 28 patients with acute facial palsy. The mean value of MBP in CSF in the study group was 3.4 +/- 0.22 micrograms/l (mean +/- SEM), which was significantly higher than the found in 37 healthy subjects (2.4 +/- 0.13 micrograms/l). Using a 95...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Edström S,Hanner P,Andersen O,Rosenhall U,Vahlne A,Karlsson B

    更新日期:1987-03-01 00:00:00

  • The relationship between hearing loss and vestibular dysfunction in patients with sudden sensorineural hearing loss.

    abstract:OBJECTIVE:To investigate the relationship between hearing loss and vestibular dysfunction in patients with sudden sensorineural hearing loss (SSHL). METHODS:Clinical data including the symptom of vertigo of 149 SSHL patients were investigated retrospectively. Pure tone audiometry, ocular vestibular-evoked myogenic pot...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1110750

    authors: Niu X,Zhang Y,Zhang Q,Xu X,Han P,Cheng Y,Gao Y,Zhang R,Yang Y,Chen Z,Hu J,Chen Y,Xu M

    更新日期:2016-01-01 00:00:00