Abstract:
CONCLUSION:The developed software (HITCal) may be a useful tool in the analysis and measurement of the saccadic video head impulse test (vHIT) responses and with the experience obtained during its use the authors suggest that HITCal is an excellent method for enhanced exploration of vHIT outputs. OBJECTIVE:To develop a (software) method to analyze and explore the vHIT responses, mainly saccades. METHODS:HITCal was written using a computational development program; the function to access a vHIT file was programmed; extended head impulse exploration and measurement tools were created and an automated saccade analysis was developed using an experimental algorithm. For pre-release HITCal laboratory tests, a database of head impulse tests (HITs) was created with the data collected retrospectively in three reference centers. This HITs database was evaluated by humans and was also computed with HITCal. RESULTS:The authors have successfully built HITCal and it has been released as open source software; the developed software was fully operative and all the proposed characteristics were incorporated in the released version. The automated saccades algorithm implemented in HITCal has good concordance with the assessment by human observers (Cohen's kappa coefficient = 0.7).
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Rey-Martinez J,Batuecas-Caletrio A,Matiño E,Perez Fernandez Ndoi
10.3109/00016489.2015.1035401subject
Has Abstractpub_date
2015-09-01 00:00:00pages
886-94issue
9eissn
0001-6489issn
1651-2251journal_volume
135pub_type
杂志文章abstract:CONCLUSIONS:Our results confirm that supracricoid laryngectomies (SL) are reliable techniques for glottosupraglottic tumors, even for selected T3 and T4 cases, if the indications are correct. These surgical techniques allow a good quality of life with the preservation of the larynx. OBJECTIVE:SL with cricohyoidoepiglo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500469024
更新日期:2006-06-01 00:00:00
abstract::One hundred and fifty-five patients with complaints indicating acute sinusitis were examined and their symptoms and signs registered. The final diagnosis--maxillary sinus empyema versus not empyema--was established by means of antral aspiration. A computer-based analysis of clinical data demonstrated the significance ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097017
更新日期:1988-03-01 00:00:00
abstract::Dynamic range (DR) of cochlear implant electrodes and speech recognition scores (SRS) were chronologically studied in 23 post-lingually deaf subjects over a period of one year. DR significantly increased over one year (ANOVA, p = 0.03). When DR was compared among three groups of electrodes which were located in the in...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137829
更新日期:1996-03-01 00:00:00
abstract::A total of 33 consecutively operated aural cholesteatomas were analysed with regard to preoperative findings and correlated with the morphology of the cholesteatoma tissue. Patients were found in all age groups, 9/33 of the patients were operated at an age below 15 years. A persistent ear discharge had occurred in all...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::Critical bandwidths and absolute intensity thresholds were measured in cats before and after kanamycin treatment which induced selective inner and outer hair cell losses. Hair cell losses were measured from cochleograms constructed from surface preparations of the organ of Corti. Results suggested that, for the test f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137179
更新日期:1979-01-01 00:00:00
abstract::T lymphocytes from tonsil (To) and peripheral blood (PB) of 4 tonsillectomized children were subjected to clonal expansion with PHA in order to analyze at single cell level their cytolytic activity and their ability to produce interleukins such as IL-2, IFN-gamma and IL-4. Analyzing all T-cell clones (CD4+ and CD8+) o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138439
更新日期:1991-01-01 00:00:00
abstract:CONCLUSION:Gene transcription and protein expression of α-ENaC showed a divergent expression in association with the development of OME induced by barotrauma. OBJECTIVES:ENaC was identified to mediate the fluid absorption through epithelia of the middle ear. This study was designed to investigate the involvement of EN...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1017888
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Endolymphatic sac decompression has shown limited success for the treatment of Ménière's disease (MD). We have published a novel technique with very promising results for the treatment of refractory MD: the Endolymphatic Duct Blockage (EDB) with two titanium clips. One of the challenges of this technique was...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1481524
更新日期:2018-10-01 00:00:00
abstract::We examined the mucosa of 50 rat middle ears in an experimental model of acute otitis media, in order to obtain information on the mechanisms of polyp formation. The right middle ear of 25 rats was inoculated with type 3 pneumococci, and the left ear served as a control. The animals were killed, the middle ear bulla r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509133351
更新日期:1995-01-01 00:00:00
abstract::Although doxorubicin [adriamycin (ADM)] ototoxicity has not been detected to date, it has been reported that neurotoxicity in the central nervous system was induced by chemotherapy with ADM in patients receiving chronic cyclosporin A (CsA) treatment. ADM ototoxicity may be induced by combination therapy with CsA becau...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480152602212
更新日期:2001-10-01 00:00:00
abstract::To investigate whether the crossed olivo-cochlear bundle (COCB) functions in a protective manner, albino guinea pigs were exposed to sounds of varying intensity (110-130 dB SPL, 3-30 min) with or without electric stimulation of COCB, and the threshold shifts of the compound action potential (CAP) were examined. A stat...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1992.11665405
更新日期:1992-01-01 00:00:00
abstract::A time-sequence study was made of the early ultrastructural changes of the stria vascularis and Reissner's membrane in the guinea pig after obliteration of the endolymphatic sac and duct. Pathological alterations of both the stria vascularis and Reissner's membrane were found to start in the apex of the cochlea. The m...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107319
更新日期:1987-09-01 00:00:00
abstract:CONCLUSION:Our results demonstrate for the first time a potentially enhanced basal secretion of monocyte chemoattractant protein-1 (MCP-1) and interleukin (IL)-17A-stimulated secretion of IL-6 from nasal polyp fibroblasts, enhanced basal secretion of IL-6 from eosinophilic nasal polyp fibroblasts, and a remarkable up-r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.796091
更新日期:2013-10-01 00:00:00
abstract::Nine subjects with long-term (8-30 years) occupational exposure to industrial solvents and a confirmed diagnosis of psycho-organic syndrome (POS) have been studied with audiological and otoneurological test batteries. The results were compared to a matched control group of nine industrial workers not exposed to solven...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127473
更新日期:1989-01-01 00:00:00
abstract::Cells can die by two distinct pathways: apoptosis and necrosis. To explore whether intense noise can induce hair cell (HC) death via the apoptotic pathway, we systematically examined morphological changes in guinea pig cochlear HC nuclei stained with Hoechst 33342, a fluorescent dye specifically labelling the nuclear ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To develop a large animal model for studies of laryngeal abductor reinnervation. MATERIAL AND METHODS:Six minipigs underwent unilateral anastomosis of the phrenic nerve-abductor branch of the recurrent laryngeal nerve (RLN). Polyhydroxybutyrate (PHB) conduits were used for repair. At each of 30, 60 and 120 d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410022507
更新日期:2004-09-01 00:00:00
abstract::Serially cultivated rat middle ear epithelium was studied under exposure to various concentrations of carbon dioxide. Three experiments were performed exposing the epithelium to a gaseous environment containing 5 or 10% CO2 or to an atmosphere almost devoid of CO2. Oxygen was maintained constant at 20% and nitrogen wa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009125165
更新日期:1990-05-01 00:00:00
abstract:CONCLUSION:These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury. OBJECTIVE:Reactive oxygen species have been shown to play a significant...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410023038
更新日期:2005-03-01 00:00:00
abstract:CONCLUSIONS:Patients with sudden hearing loss and dizziness after barotrauma should be suspected of barotraumatic perilymph fistula (PLF). Early surgical repair of PLF showed better hearing outcomes. Therefore, diagnostic criteria should help surgical indications of barotraumatic PLF. OBJECTIVES:The aim of this study ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1213419
更新日期:2017-01-01 00:00:00
abstract:CONCLUSIONS:Our preliminary results indicate that mastoidectomy by reconstruction of the posterior wall and obliteration (MAPRO) avoided the disadvantages of a canal-wall-down mastoidectomy. MAPRO effectively prevented cholesteatoma recurrence, provided an excellent basis for hearing restoration, and was generally wate...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.643456
更新日期:2012-04-01 00:00:00
abstract::We examined the serial changes of intravenously applied dye leakage and preliminary examined histamine release into nasal lavage fluid after topical stimulation with capsaicin in guinea pigs. A significant increase in the dye leakage response was detected for 30-40 min, with the maximum response occurring between 5 an...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137438
更新日期:1992-01-01 00:00:00
abstract::The input from fore- and hindlimbs to the vestibular nuclear complex (VNC) was investigated in awake cats. Electrical stimulus was given to the sciatic, radial and vestibular nerves bilaterally and single unit responses were recorded in the VNC with extracellular technique. The position of the microelectrode was histo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909126395
更新日期:1979-01-01 00:00:00
abstract::A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128897
更新日期:1982-07-01 00:00:00
abstract:CONCLUSIONS:Increased expression of Dicer may be a prognostic biomarker for patients with laryngeal squamous cell carcinoma (LSCC). OBJECTIVES:Recent studies have shown that many microRNAs (miRNAs) play an important role in the development and progression of human cancers. Dicer, one of the most important enzymes of t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.920962
更新日期:2014-09-01 00:00:00
abstract::The early development of human otoconial membranes was studied by scanning electron microscopy and X-ray microanalysis; 87 specimens, ranging from 7 to 12 weeks gestational age were examined. A few otoconia, which contained calcium, were present in the utricle by the end of the seventh week. By 8 weeks, both the saccu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128884
更新日期:1982-07-01 00:00:00
abstract::We established new cell lines from head and neck cancer patients for studies of adhesion molecules and cellular behavior in nine patients with primary or metastatic cancer treated at the Asan Medical Center. Explant cultures of fresh tumor tissue were used to develop new permanent tumor cell lines. Lines were tested f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113477
更新日期:1997-09-01 00:00:00
abstract::Volumetric changes of the scala media were histologically investigated in normal guinea pigs to see whether glycerol-induced volumetric change of the scala media followed a biphasic course similar to the auditory threshold in the glycerol test. Glycerol was administered orally in a 12 ml/kg dose. The volume of the sca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181369
更新日期:1999-01-01 00:00:00
abstract::Outer hair cells (OHCs) are the source of otoacoustic emissions, following a tropomyosin-miosin-dependent contraction, which are regulated by the olivocochlear bundle via the release of acetylcholine (ACh). ACh acts on ACh receptors (AChR) located on the OHC post-synaptic membrane. In myasthenia gravis (M.G.) neuromus...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043127
更新日期:2001-01-01 00:00:00
abstract::In this experimental study in the rat, compound 48/80--a potent degranulating drug of mast cells--was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympani...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128942
更新日期:1982-11-01 00:00:00
abstract:CONCLUSION:Endoscopic cauterization of the sphenopalatine artery and anterior ethmoid artery is a first-line standard of care in managing intractable epistaxis, after the failure of previous packing. Epistaxis occurs in 12% of the population. Treatment is often based on nasal packing that could be poorly effective in t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.3109/00016481003621538
更新日期:2010-09-01 00:00:00