Abstract:
:T lymphocytes from tonsil (To) and peripheral blood (PB) of 4 tonsillectomized children were subjected to clonal expansion with PHA in order to analyze at single cell level their cytolytic activity and their ability to produce interleukins such as IL-2, IFN-gamma and IL-4. Analyzing all T-cell clones (CD4+ and CD8+) obtained from To in comparison with those from PB, a reduced proportion of cells with lectin-dependent cytolytic activity (LDCC) (25% vs. 42%, p less than 0.01) and natural killer (NK) activity (18% vs. 31%, p less than 0.02) was found. These differences were proportionally related to the lower number of CD8+ T-cells in To than in PB. The proportion of CD4+ clones able to produce IL-2 and/or IL-4 were higher in To (75% and 61%) than in PB (52% and 25%, p less than 0.001 and p less than 0.001, respectively). In contrast, the proportion of CD4+ clones able to produce IFN-gamma was similar (53% and 58%) in both series of clones. According to the patterns of lymphokine synthesis, tonsillar T-cells differed from PB T-cells as follows: 1) the number of Th1-like CD4+ clones producing IL-2 and/or IFN-gamma (but not IL-4) were 23% vs. 44% in PB (p less than 0.001); 2) there was no difference between To and PB in the proportion of CD4+ clones producing IL-4 alone (Th2 clones: 9% vs. 8%); 3) CD4+ clones synthesizing IL-2, IL-4 and IFN-gamma at the same time were more frequent in To than in PB (Th3 clones: 53% vs. 17%, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Gallo O,De Carli M,Gallina E,Toccafondi G,Romagnani S,Del Prete Gdoi
10.3109/00016489109138439subject
Has Abstractpub_date
1991-01-01 00:00:00pages
974-80issue
5eissn
0001-6489issn
1651-2251journal_volume
111pub_type
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journal_title:Acta oto-laryngologica
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doi:10.3109/00016488809119451
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doi:10.3109/00016488609108631
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journal_title:Acta oto-laryngologica
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doi:
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更新日期:1999-01-01 00:00:00
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doi:10.3109/00016489509139402
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