Abstract:
OBJECTIVE:To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). METHODS:We have performed an ELISA-based CTP detection test using middle ear lavage (MEL) samples from 497 cases of suspected PLF enrolled from 70 clinical centers nationwide between 2014 and 2015. In addition to the CTP-positive rate, audio-vestibular symptoms were compared between CTP-positive and -negative cases. RESULTS:8-50% of patients in category 1 (trauma, middle and inner ear disease cases), and about 20% of those in categories 2, 3 and 4 (external origin antecedent events, internal origin antecedent events, and without antecedent event, respectively) were positive for CTP. In category 1 cases, the earlier tested samples showed a higher CTP-positive rate, whereas no differences were observed in categories 2, 3 or 4. The characteristic clinical features in the earlier tested cases were nystagmus and fistula sign in CTP test-positive cases in category 1, and streaming water-like tinnitus in those in categories 2, 3 and 4. CONCLUSION:The present study clarified that CTP detection test-positive patients exist at considerable rates among patients with inner ear-related manifestations.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Matsuda H,Sakamoto K,Matsumura T,Saito S,Shindo S,Fukushima K,Nishio SY,Kitoh R,Shibasaki O,Ito A,Araki R,Usami SI,Suzuki M,Ogawa K,Hasegawa T,Hagiwara Y,Kase Y,Ikezono Tdoi
10.1080/00016489.2017.1300940subject
Has Abstractpub_date
2017-01-01 00:00:00pages
S53-S59issue
sup565eissn
0001-6489issn
1651-2251journal_volume
137pub_type
临床试验,杂志文章,多中心研究abstract:CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500395179
更新日期:2006-12-01 00:00:00
abstract::Serially cultivated rat middle ear epithelium was studied under exposure to various concentrations of carbon dioxide. Three experiments were performed exposing the epithelium to a gaseous environment containing 5 or 10% CO2 or to an atmosphere almost devoid of CO2. Oxygen was maintained constant at 20% and nitrogen wa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009125165
更新日期:1990-05-01 00:00:00
abstract:CONCLUSION:Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. OBJECTIVES:The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contrib...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480903168066
更新日期:2010-03-01 00:00:00
abstract::Recent investigations of children with specific language impairment (SLI) have found deviant anatomical asymmetry of the perisylvian cortex. These studies argue that this deviant anatomical asymmetry is linked to the language disorders of SLI children. To date no studies have examined whether deviant functional asymme...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043929
更新日期:2001-01-01 00:00:00
abstract:CONCLUSIONS:Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which are essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal epithelial cells. Considering that the ligand for TLR3 is viral dsRNA, this result is in good...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601089416
更新日期:2007-04-01 00:00:00
abstract::Synchronous benign and malignant tumors in the ipsilateral salivary glands are extremely rare. We report a unique case of synchronous unilateral parotid tumors in a 71-year-old man. The main parotid lesion was preoperatively suggested to be adenocarcinoma by fine needle aspiration cytology. A coexisting Warthin's tumo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600606707
更新日期:2007-01-01 00:00:00
abstract::To predict the possible benefit of a cochlear implant to a patient, the clinician requires a reliable objective method to monitor the presence of surviving fibres in the 8th nerve. The subjective promontory test and the evaluation of electrically evoked brainstem potentials are not adequate. An electrical stimulus art...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126093
更新日期:1994-09-01 00:00:00
abstract::This is a study of the effects of repeated angular acceleration on the activity of vestibular nuclei units in anesthetized and in conscious cats. The experimental animals were subjected to trains of repeated and consecutive constant acceleration-deceleration ramps (4-8 degrees/sec2). In a few cases nystagmus was recor...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009131713
更新日期:1980-09-01 00:00:00
abstract::Different analysis methods for the objective measurements of body sway were examined to establish the most sensitive method for identifying changes in stability. Changes between stability with eyes open and eyes closed were used to assess the techniques. Body sway was measured in a group of normal subjects standing on...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126028
更新日期:1994-03-01 00:00:00
abstract::The results of House Brackmann and Yanagihara grading were compared with electroneurographic (ENoG) data in 30 consecutive patients with Bell's palsy. The examinations were made on mean days 11, 36 and 99. Twenty-four patients had a favourable outcome (Yanagihara > or = 36 at three months). Based on our observations, ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850182440
更新日期:1998-11-01 00:00:00
abstract::This study aimed to investigate whether unilateral vestibular neuritis (VN) causes the same deficits of ocular counter-roll during static head roll (OCR(S)) and dynamic vestibulo-ocular reflex gains during head impulses (VOR(HI)) as unilateral vestibular deafferentation (VD). Ten patients with acute and 14 patients wi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180379
更新日期:1999-01-01 00:00:00
abstract::We established new cell lines from head and neck cancer patients for studies of adhesion molecules and cellular behavior in nine patients with primary or metastatic cancer treated at the Asan Medical Center. Explant cultures of fresh tumor tissue were used to develop new permanent tumor cell lines. Lines were tested f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113477
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVES:This study was conducted to demonstrate the safety and efficacy of the Otologics Middle Ear Transducer (MET) Ossicular Stimulator and, in particular, to compare the audiologic benefits of this novel form of electromechanical stimulation with those of conventional acoustical amplification. MATERIAL AND METHO...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016480410016298
更新日期:2004-05-01 00:00:00
abstract:CONCLUSION:Chronic subjective dizziness (CSD) is frequent and affects twice as many women as men. Anxiety is a strong predisposing factor. The pathophysiologic concept of this disorder assumes that balance function and emotion share common neurologic pathways, which might explain that the balance disorder can provoke f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701805455
更新日期:2008-10-01 00:00:00
abstract::It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar ca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701687283
更新日期:2008-06-01 00:00:00
abstract::Detection of immune complexes (ICs) of IgG, IgM, or IgA isotypes in middle ear effusions (MEEs) by the solid-phase anti-C3 ELISA and cytologic analyses of MEEs were done in 245 patients with otitis media with effusion (OME). In 320 ears, the clinical classification was acute, 10.3%; subacute, 16.6%; chronic, 73.1%. In...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709128278
更新日期:1987-11-01 00:00:00
abstract::The occurrence of symptoms from the upper airways in the furniture industry was studied by means of a questionnaire which was answered by 676 wood furniture workers from 50 different factories. Twenty per cent reported nasal hypersecretion and 40% nasal obstruction. A randomized sample of 61 workers was investigated f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107596
更新日期:1984-11-01 00:00:00
abstract:CONCLUSION:The existence of patients with positive non-sentinel node indicates a risk of misdiagnosis of metastasis in oropharyngeal and oral cancer. OBJECTIVES:We attempted to confirm the usefulness of sentinel lymph node biopsy (SLNB) in oropharyngeal and oral cavity cancer to detect clinically occult metastases. P...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480801891710
更新日期:2008-10-01 00:00:00
abstract::Utilizing an enlarged middle cranial fossa approach to the cerebello-pontine angle without destruction of the labyrinth or cochlea the authors have since 1981 operated on 263 unilateral acoustic neurinomas. Tumour sizes ranged between 3 mm intrameatal and 35 mm within the cerebello-pontine angle. Complete tumour remov...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137419
更新日期:1992-01-01 00:00:00
abstract:CONCLUSION:We report a distinct pattern of tongue movement. This is interpreted as a compensatory mechanism after hypopharyngo-laryngectomy with reconstruction using a jejunal autograft. Passage through the oesophagus is mainly passive. OBJECTIVE:Swallowing is normally initiated voluntarily, and afterwards presumed to...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016481003664785
更新日期:2010-09-01 00:00:00
abstract::The influence of cigarette smoke on the pharyngeal mucosa was investigated in a clinical study and in an experiment on animals. Histologic reports were evaluated according to the Kambic-Lenart classification of hyperplastic aberrations of the throat mucosa. A close dependence of the degree of hyperplasia and the numbe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121433
更新日期:1978-01-01 00:00:00
abstract::Gaze functions under high-frequency head oscillations with large amplitudes were investigated in 12 normal subjects. Oscillation amplitude decreased as the frequency increased (31 degrees at 2 Hz to 11 degrees at 5 Hz on average). Maximum head velocity and acceleration were 170-200 degrees/s and 2,500-5,000 degrees/s2...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127495
更新日期:1989-03-01 00:00:00
abstract::The diagnosis and management of spontaneous otogenic pneumocephalus with literature review is described. A young sportsman experienced headache and fluctuating mass in his occiput during increased physical activity. A large extradural intracranial pneumocephalus with corresponding emphysema was imaged on a CT scan. Tr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489.2010.541941
更新日期:2011-06-01 00:00:00
abstract::Using electron microscopy and GABA immunohistochemistry we evaluated the effects on human embyronic organ of Corti tissue culture of exposure to the ototoxic aminoglycoside antibiotic neomycin at a dose of 1 mM for 48 to 96 hrs. Neomycin induces the formation of multilamellar myeloid structures. These lesions, found o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137929
更新日期:1996-11-01 00:00:00
abstract:CONCLUSION:Bilateral electric acoustic stimulation (EAS) effectively improved speech perception in noise and sound localization in patients with high-frequency hearing loss. OBJECTIVE:To evaluate bilateral EAS efficacy of sound localization detection and speech perception in noise in two cases of high-frequency hearin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.951453
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:The authors would like to confirm a fluid pathway from the scala tympani to the organ of Corti, and to observe its morphological changes. METHODS:A staining solution for succinic dehydrogenase was perfused with phenazine methosulfate in the scala tympani of living guinea pigs (n = 5) under deep anesthesia. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1185541
更新日期:2016-11-01 00:00:00
abstract:CONCLUSION:The occult metastasis rate for T2 oral cancer can be reduced by ultrasonography (US). Also, the late metastasis rate is considered to be reduced by combining US with frozen section biopsy (FSB) during supraomohyoid neck dissection (SOHND). OBJECTIVES:Early oral cancer has been reported to show occult metast...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.598553
更新日期:2011-11-01 00:00:00
abstract::The postnatal development of the Eustachian tube (ET) and its surrounding structures was investigated by means of computer-aided three-dimensional (3-D) reconstruction methods in 13 normal human temporal bones, obtained from individuals 3 months to 71 years old. The cross-sectional area, width and height of the lumen ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850182549
更新日期:1998-11-01 00:00:00
abstract::The Dynamic Illegible E (DIE) test measures visual acuity with head held still while reading a specially designed visual acuity chart of E's. The head is then moved passively and the change in visual acuity is recorded. The DIE test has previously been shown to be very useful for assessing patients with aminoglycoside...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:CONCLUSIONS:It has been shown that TRPMs may play a functional role in sensory cell physiology, fluid homeostasis, sensory cell death, and thermosensation in the inner ear, while TRPA1 plays an important role in sensory transduction. OBJECTIVE:To study expression of TRPM1-8 and TRPA1 in the mouse inner ear. MATERIALS...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802570545
更新日期:2009-10-01 00:00:00