Cough reflex induced by capsaicin inhalation in patients with dysphagia.

Abstract:

CONCLUSIONS:We conclude that the capsaicin inhalation test is useful to directly assess cough reflex and sensation around the larynx, while it indirectly reflects central nervous system function. OBJECTIVES:To understand the state of the cough reflex before patients with dysphagia start eating. METHODS:We studied the cough reflex by the capsaicin inhalation test in 21 patients with dysphagia and 12 healthy persons without dysphagia. RESULTS:The control group showed a cough reflex at a capsaicin concentration of 2.61 μM (0.98-7.80), while patients with mild dysphagia did so at 7.28 μM (1.95-15.6), those with moderate dysphagia at 22.07 μM (15.6-62.5), and those with severe dysphagia at 71.75 μM (31.2-250). Control vs mild p < 0.01, control vs moderate p < 0.01, control vs severe p < 0.01, mild vs moderate p < 0.01, mild vs severe p < 0.01, moderate vs severe p < 0.05. There was a significant correlation between the grade of dysphagia and the threshold capsaicin concentration that provoked a cough reflex (ρ = -0.796, p < 0.001).

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Imoto Y,Kojima A,Osawa Y,Sunaga H,Fujieda S

doi

10.3109/00016489.2010.516013

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

96-100

issue

1

eissn

0001-6489

issn

1651-2251

journal_volume

131

pub_type

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