Abstract:
:Thorotrast(R) containing thorium dioxide particles with diameters of around 100 Å was introduced in perilymph or endolymph using various methods and concentrations. The location of the tracer particles in the cochleas was determined using the transmission electron microscope. Injection of tracer into the cerebrospinal fluid (CSF) was considered to be the least unphysiological way to bring the tracer to the cochlea, and therefore most of the experiments were performed in that way. The distribution of tracer was very dependent on the mode of injection and the concentration of tracer in the cochlea. With very high concentrations it appeared that every kind of cell had a capacity of phagocytizing. No significant tracer uptake was noted in the cells of the organ of Corti after direct injection of small amounts of tracer in the cochlear duct. After tracer administration in the cerebrospinal fluid, the tracer rapidly reached the scala tympani. The tympanic border cells contained large numbers of tracer particles, while lesser amounts were found in the homogenous parts of the basilar membrane. No tracer was seen in the cells of the organ of Corti. After perfusion of the cochlear perilymph, some tracer was seen in the cells of the organ of Corti. The limited passage of tracer to the organ of Corti was not regarded as proof of free communication between perilymph and cortilymph. Glycerol administration to the animals did not change the propagation of tracer in the cochlea. After injection of tracer into dead animals, tracer inclusions could be seen in the tympanic border cells, indicating the possibility of a cell phagocytizing ability, also some time after death.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Angelborg Cdoi
10.1080/16512251.1974.11675750subject
Has Abstractpub_date
1974-01-01 00:00:00pages
19-41issue
319eissn
0001-6489issn
1651-2251journal_volume
77pub_type
杂志文章abstract:CONCLUSION:Our results suggest that hepatocyte growth factor (HGF) may play an important role in the progression of hypopharyngeal cancer. OBJECTIVE:HGF, a potent stimulator of hepatocyte growth, stimulates the motility, invasiveness, proliferation and morphogenesis of epithelium and may be involved in physiologic and...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510037014
更新日期:2006-01-01 00:00:00
abstract:CONCLUSIONS:Concurrent chemoradiotherapy with carboplatin and uracil-f tegafur (UFT) seems to be a promising and appropriate regimen for patients with poor performance status (PS) with locally advanced squamous cell carcinoma of the head and neck (SCCHN). OBJECTIVE:We designed a regimen based on divided low-dose admin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016480701200251
更新日期:2007-10-01 00:00:00
abstract:CONCLUSION:The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary tumour. The approach presented in this first Scandinavian study could p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1052983
更新日期:2015-01-01 00:00:00
abstract::The waltzing guinea pig exhibits genetically induced inner ear disease which develops into deafness and vestibular disorder. The type I hair cell in vestibular end organs shows specific pathology, featuring protrusion of the hair cell apex, sensory hair fusion and an intracellular actin filament rod. With the freeze-f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309132893
更新日期:1983-09-01 00:00:00
abstract::Urokinase-type plasminogen activator (uPA) is important for matrix degradation and motility of cancer cells. The binding of uPA to its cell surface receptor on cancer cells is essential for effective invasion. A soluble form of urokinase receptor (suPAR) has been described in serum and ascites of ovarian cancer patien...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180342
更新日期:1999-01-01 00:00:00
abstract::The experimental use of jejunal free grafts with microvascular anastomosis in the head and neck region has been reported in pharyngeal and esophageal reconstruction. Lack of a suitable animal model has limited basic research for cutaneous or myocutaneous microvascular techniques. This investigation upon appropriate gr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107574
更新日期:1984-09-01 00:00:00
abstract::The submucosal glands in the rat nose are characterized by the presence of both neutral and acid glycoproteins, which are important constituents of nasal and tracheobronchial secretions. This study is an attempt to gain a better insight into the secretion of these two types of glycoproteins and its neural regulation. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709128287
更新日期:1987-11-01 00:00:00
abstract:CONCLUSION:Bilateral electric acoustic stimulation (EAS) effectively improved speech perception in noise and sound localization in patients with high-frequency hearing loss. OBJECTIVE:To evaluate bilateral EAS efficacy of sound localization detection and speech perception in noise in two cases of high-frequency hearin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.951453
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To ascertain whether a daily nasal spray with physiological saline could prevent symptoms of common cold in a population of otherwise healthy adults. MATERIAL AND METHODS:This was study involving 10 weeks of daily use of a nasal saline spray and 10 weeks of only recording symptoms. Young adults eligible for ...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/00016480410017657
更新日期:2004-11-01 00:00:00
abstract:CONCLUSIONS:We conclude that: (1) among several cues examined, the monaural cue of direct-to-reverberant (D/R) ratio in the ipsilateral ear provides the most information about sound-source distance; (2) interaural level difference (ILD) provides less information about sound-source distance; and (3) a comprehensive theo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701840114
更新日期:2008-04-01 00:00:00
abstract:CONCLUSIONS:Protocol limitations were identified and accounted for in the analysis. Percent gradient equilibrated (PGE) was affected by driving gradient direction in a similar manner to other efficiency measures. A finer resolution of possible age-related changes in eustachian tube opening efficiency is expected with t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.882017
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Combination therapy consisting of a platinum agent, 5-fluorouracil and cetuximab (EXTREME regimen) is recommended for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN). However, it is advisable to use platinum-free regimens as first-line therapy in patients resistant to platinu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016489.2018.1551623
更新日期:2019-02-01 00:00:00
abstract::A thorough examination of hearing and hearing loss among workers in the saw- and papermill industries in northern Sweden showed that even a serious hearing loss does not give the expected social handicap. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609119960
更新日期:1976-03-01 00:00:00
abstract::One hundred patients subjected to tonsillectomy because of recurrent acute tonsillitis or tonsillar hypertrophy were evaluated bacteriologically both with ordinary throat culturing and cultures from tonsillar cores. In 26% of the patients H. influenzae was isolated and in 20% beta-haemolytic group A streptococci. Grow...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009107448
更新日期:1990-03-01 00:00:00
abstract::The three-dimensional distribution of the cricoid area was investigated using computer graphics and its histological structure and pathology were studied using whole-organ serial sections. A total of 26 adult human larynges were examined. The findings were as follows: 1. Cricoid areas were located along the superior p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract:CONCLUSIONS:The distortion product otoacoustic emission (DPOAE) amplitudes in diabetics were significantly lower than those in controls when pure tone audiometry (PTA) was within normal limits, implying cochlear function impairment in the early stage of diabetes mellitus. Retrocochlear damage was suggested by elongated...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,meta分析,评审
doi:10.1080/00016489.2016.1223344
更新日期:2017-02-01 00:00:00
abstract::The feasibility of furosemide test for the detection of endolymphatic hydrops has previously been discussed (Authors, 1973, 1975). The glycerol test also has been reported as being effective for the same purpose but only in Meniere patients with fluctuating hearing loss (Klockhoff & Lindblom, 1966). In 48 patients wit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128845
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVE:To quantitatively analyze modifications of the paratubal muscles in developing Wistar rats following nasal obstruction. MATERIAL AND METHODS:Twenty-four Wistar rats were used. Twelve were examined at 6, 8 and 12 weeks after birth and were considered normal controls. The nostrils of the remaining 12 rats were...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001141
更新日期:2003-01-01 00:00:00
abstract::We have developed a new technique for analyzing the rotation vector of eye movement in three dimensions with an infrared CCD camera based on the following four assumptions; i) the eye rotates on a point; ii) the pupil edge is a circle; iii) the distance from the center of eye rotation to pupil circle remains unchanged...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181882
更新日期:1999-01-01 00:00:00
abstract::The blowing of chilled (14 degrees C) air into the external auditory canal (EAC) resulted in a profuse middle ear fluid production. The stimulation caused marked changes in the pars flaccida of the tympanic membrane. A slight vasodilatation was noted in the oedematous loose connective tissue layer of the pars flaccida...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609108674
更新日期:1986-09-01 00:00:00
abstract:CONCLUSIONS:Auricle reconstruction combined with hearing reconstruction can help patients with microtia to obtain practical hearing improvement as well as cosmetic improvement. The integrated procedures can facilitate the incision design and obtain a natural-looking three-dimensional shape of the reconstruction auricle...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.662716
更新日期:2012-08-01 00:00:00
abstract::Surgery and radiotherapy are still the best local and regional treatments for the majority of head and neck cancer patients, each alone having an impressive cure rate. However, it appears that surgery and radiotherapy have reached their upper limits. To improve the results obtained by surgery and radiotherapy, combine...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,评审
doi:10.3109/00016488909127520
更新日期:1989-05-01 00:00:00
abstract::In this experimental study in the rat, compound 48/80--a potent degranulating drug of mast cells--was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympani...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128942
更新日期:1982-11-01 00:00:00
abstract::The inner ear responds immunologically to foreign proteins and pathogens introduced into the cochlea. The route of entry of the cells participating in the inner ear inflammatory process is the spiral modiolar vein with its collecting venules. Since this vein is located adjacent to the scala tympani, the end result of ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489009107455
更新日期:1990-11-01 00:00:00
abstract::A method is described for the intravital microscopic observations of rabbit tracheal mucosa microcirculation during compression with a thin, transparent high volume cuff. The cuff pressure (CP) required to cause complete ischemia in the mucosa over the cartilages was measured and a correlation was found to the mean ar...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137192
更新日期:1979-01-01 00:00:00
abstract::The expression of vascular cell adhesion molecule-1 (VCAM-1), alpha4-integrin and L-selectin was dynamically observed using an immunohistochemical approach during labyrinthitis induced by inoculation of keyhole limpet hemocyanin into the scala tympani of animals that had been systemically sensitized to it. At the same...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000414
更新日期:2000-08-01 00:00:00
abstract::Seven to eight years after a disease period of vestibular neuritis 19 patients previously examined at our department were given a questionnaire about whether they had experienced any audiovestibular symptoms since they first fell ill. All 19 patients responded and 18 consented to participate in the long-term follow-up...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180243
更新日期:1999-01-01 00:00:00
abstract::It has previously been shown that simple compounds with multiple amine groups are ototoxic, the degree of ototoxicity depending on the number of amine groups in the molecule. The relationship between the number of amino groups and ototoxicity in aminoglycoside was studied using kanamycin A and kanamycin B, which conta...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709134700
更新日期:1987-01-01 00:00:00
abstract::Cochlear microphonics (CM) were recorded in the guinea pig using differential recording from the first and third cochlear turns as well as by using a 10-electrode array inserted in the scala tympani of the basal turn. The excitation profile as represented by the CM was quantified by amplitude and phase data, and was m...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121465
更新日期:1978-05-01 00:00:00
abstract::Background: The treatments of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) have low remission rates ranging between 60% and 90%, connected to the difficulty in correctly identifying the affected side of HSC-BPPV. Objective: To propose and compare the efficacy of the latency test (LT) i...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1635712
更新日期:2019-10-01 00:00:00