Abstract:
:Oxytocin is one of the most potent uterotonic agents and is known to fluctuate throughout the menstrual cycle, showing an increase during sexual stimulation and arousal, with a peak during orgasm in women. To date, limited data are available on the effects of oxytocin on the regulation of uterine contractility and transport mechanisms in human reproduction. The goal of this study was to evaluate the effects of oxytocin on uterine contractility and peristalsis in estrogen-primed non-pregnant uteri. In an extracorporeal perfusion model of the swine uterus the effect of dynamic changes in uterine contractility and peristalsis in response to oxytocin and estrogen administration was observed. Spontaneous uterine contractility and oxytocin-induced uterine contractility and peristalsis with and without estrogen perfusion were assessed using an intrauterine double-chip microcatheter. Spontaneous peristalsis and oxytocin induced contraction waves without estrogen perfusion resulted in a slightly higher intrauterine pressure in the isthmus uteri in comparison with the corpus uteri, while the peristaltic waves were seen to start mostly in the corpus uteri, moving in the direction of the cervix. While after estrogen perfusion oxytocin produced a significant increase in intrauterine pressure in the isthmus uteri compared to the corpus uteri, and 80% of the peristaltic waves started in the isthmus uteri, moving in the direction of the corpus uteri. This observation strengthens the view that oxytocin is able to support directed transport mechanism in the female genital tract only in the presence of estrogens. The biological role of oxytocin increase during sexual stimulation and arousal with a peak during orgasm for the mechanisms of reproduction may be to stimulate directed uterine transport mechanisms in the presence of estrogens.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Müller A,Siemer J,Renner S,Hoffmann I,Beckmann MW,Dittrich Rsubject
Has Abstractpub_date
2006-04-28 00:00:00pages
157-62issue
4eissn
0949-2321issn
2047-783Xjournal_volume
11pub_type
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-12-537
更新日期:2011-12-02 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-10-415
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-03-26 00:00:00
abstract::Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granu...
journal_title:European journal of medical research
pub_type: 杂志文章
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2006-08-30 00:00:00
abstract:BACKGROUND:In subtotal central retinal artery occlusion (CRAO), distinct retinal edema with acute onset irreversible visual loss is common. - METHODS:Clinical observation, fluorescein angiogram. - PATIENT:A 69-year-old patient presented with acute visual loss of his right eye. Risk factors for CRAO were arterial hype...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2006-01-31 00:00:00
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journal_title:European journal of medical research
pub_type: 历史文章,杂志文章
doi:
更新日期:1999-06-28 00:00:00
abstract::We report the case of a 64-year old woman with severe attacks of allergic alveolitis occurring frequently independent of a concrete place. These attacks were regularely preceded by diarrhoe. Laboratory data showed marked leukopenia and circulating Candida albicans (C.a.)-antigen. Bronchoalveolar lavage revealed an inc...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2000-03-27 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
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更新日期:2000-05-23 00:00:00
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journal_title:European journal of medical research
pub_type: 总体
doi:
更新日期:2000-11-30 00:00:00
abstract::More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-20 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:10.1186/2047-783x-14-s4-71
更新日期:2009-12-07 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1997-06-16 00:00:00
abstract::Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-02-25 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-25 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:2004-05-28 00:00:00
abstract::Though AIDS-related morbidity and mortality are generally decreasing as a result of highly active antiretroviral therapy (HAART) and prevention of opportunistic infections, dual infection with HCV and HIV leads to an acceleration in the natural course of chronic hepatitis C (cHC) and worsening of associated liver dise...
journal_title:European journal of medical research
pub_type:
doi:
更新日期:2002-01-29 00:00:00
abstract:OBJECTIVE:Most industrialized countries experienced a change in dietary habits within the last 10 years. Growing obesity may result in an increased incidence of metabolic diseases as well as in a higher caries frequency. METHODS:In an interdisciplinary study, 842 elementary school children (414 girls and 428 boys, age...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2004-08-31 00:00:00
abstract:BACKGROUND:Bone fracture is one of the most common physical injuries in which gene expression and the microenvironment are reprogramed to facilitate the recovery process. METHODS:By specific siRNA transfection and MTT assay, we evaluated the effects of metastasis-associated gene 1 (MTA1) in osteoblast growth. To show ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0084-x
更新日期:2015-02-03 00:00:00
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-04-30 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:1996-03-19 00:00:00
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journal_title:European journal of medical research
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更新日期:2013-11-23 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN:This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio grou...
journal_title:European journal of medical research
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更新日期:2017-10-18 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1998-06-17 00:00:00
abstract::Triple A (four A; Allgrove syndrome) syndrome is a an autosomal recessive disorder characterized by alacrimia, achalasia, adrenocortical insufficiency, and various neurological abnormalities. We report a case of triple A syndrome in a 14-year-old female patient together with oral manifestations. The importance of this...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2003-07-31 00:00:00
abstract:OBJECTIVE:Efavirenz (EFV) plasma levels have been discussed as a predictor of treatment failure in HIV infected patients. The aim of this prospective, open-labeled, case-control study was to evaluate pretreated patients in regards to efavirenz plasma levels and efficacy of therapy. METHODS:Blood samples were obtained ...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-07-24 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:2005-08-17 00:00:00