Abstract：
BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of patients with G-SMT in an analysis of prospectively collected data. PATIENTS AND METHODS:Forty-seven consecutive patients with G-SMT treated at our institution between 1994 and 2000, were included. All patients underwent abdominal ultrasound and EUS, and in case of suspicious findings or a tumor size > 2 cm EUS fine needle aspiration (EUS-FNA) was performed. Patients were operated on if a malignant tumor was suspected (tumor size > 2 cm; detection of metastases) or if complications occurred (e.g. bleeding, ulceration). RESULTS:All 47 patients were included in this study. Typical symptoms were nausea (64%), bleeding (11%) and pain (9%). EUS showed a G-SMT averaging 6.4 (0.8 - 30) cm in size. EUS-FNA was performed in 24 patients revealing PAP III (n = 1), PAP II (n = 21) and PAP I (n = 2) scores. Surgery was performed in 33 patients, revealing gastrointestinal stromal tumors (GISTs) in 18 patients as well as several other malignant and non-malignant lesions. During follow-up (median 37 months), none of the conservatively treated patients (n = 14) developed a malignant tumor. CONCLUSIONS:In one third of our patients surgery could be avoided with this strategy. No delayed diagnosis of a malignant tumor during follow-up was established. Small G-GMT's should be monitored conservatively if diagnostic procedures and follow-up was performed by EUS and eventually EUS-FNA.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Sato T,Peiper M,Fritscher-Ravens A,Gocht A,Soehendra N,Knoefel WTsubject
Has Abstractpub_date
2005-07-29 00:00:00pages
292-5issue
7eissn
0949-2321issn
2047-783Xjournal_volume
10pub_type
临床试验,杂志文章abstract：BACKGROUND:The purpose of this study was to assess the association between leisure-time physical activity (LPA) and the risk of metabolic syndrome (MS). METHODS:Prospective cohort studies of the association between LPA and the risk of MS were retrieved from the PubMed and Embase databases up to 12 August 2013. The sta...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析,收录出版
doi：10.1186/2047-783X-19-22
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abstract：BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant tumor syndrome predisposing to predominantly colorectal and endometrial cancer. In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MS...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-01-28 00:00:00
abstract：BACKGROUND:Relatively large calcific tendinitis with persistent symptoms after extended periods of conservative treatment is an indication for operative therapy. Arthroscopy, as a treatment for calcific tendinitis of the hip abductors and calcinosis circumscripta, has been described previously; however, to our knowledg...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-49
更新日期：2013-11-23 00:00:00
abstract：OBJECTIVE:The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail. METHODS:Human MSCs were isolated and cultivated onto the surface of a 3 x 3 mm porcine collagen I / III carrier. After incubation, cell cultur...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-1-35
更新日期：2010-01-29 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
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abstract：BACKGROUND:Focal colorectal uptake in (18)FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluation and below which for individual assessment. PURPOSE:To determine the lowest maximum standar...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0195-z
更新日期：2016-01-09 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-04-30 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-05-24 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-11-28 00:00:00
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journal_title：European journal of medical research
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更新日期：2021-01-18 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-08-16 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2007-05-29 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1995-12-18 00:00:00
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
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更新日期：1998-02-21 00:00:00
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journal_title：European journal of medical research
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更新日期：2008-11-24 00:00:00
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更新日期：2004-08-31 00:00:00
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journal_title：European journal of medical research
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更新日期：2014-08-23 00:00:00
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更新日期：2008-07-28 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-08-18 00:00:00
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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doi：
更新日期：2003-08-20 00:00:00
