Abstract：
INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination of cisplatin plus gemcitabine in an adjuvant setting. Following recurrence the multi-kinase inhibitor sunitinib was administered. RESULTS:Radical nephrectomy with lymphadenectomy revealed CDC in stage pT3a pN2 M0 G3 R0 in both patients. 4 courses of adjuvant chemotherapy with cisplatin 70 mg/m superset2 and gemcitabine 1,500 mg/m superset2 were given. Side effects according to the NCI 3.0 common toxicity criteria were limited to grade 2 asthenia and grade 2 thrombozytopenia/leucopenia. Restaging revealed local recurrence and lymph node metastases. Both patients were re-operated and metastatic CDC was found. Second line therapy with sunitinb malatat (Sutent superset, Pfizer Inc. U.S.) at 50mg p.o. was given. Grade 3 leucopenia and thrombocytopenia and grade 2 asthenia and mucositis were not dose-limiting. After two cycles multiple liver, lung and bone metastases and mediastinal lymphopathy occured. 8 weeks later the patients died with a survival of 8 months from initial diagnosis. CONCLUSIONS:Adjuvant gemcitabine plus cisplatin did not delay recurrence of CDC after surgery. Metastasectomy either had no influence on the course of disease. Anti-angiogenetic therapy with sunitinib treatment was not effective, possibly related to a low vascular density (CD31 expression) in CDC.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Staehler M,Haseke N,Schöppler G,Stadler T,Karl A,Siebels M,Ihrler S,Stief CGsubject
Has Abstractpub_date
2008-11-24 00:00:00pages
531-5issue
11eissn
0949-2321issn
2047-783Xjournal_volume
13pub_type
杂志文章abstract：OBJECTIVE:The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). METHODS:Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF,...
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-11-17 00:00:00
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journal_title：European journal of medical research
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