Abstract：
OBJECTIVE:This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD). METHODS:A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to the presence of NPE: central nervous system disease (CNSD) group and NPE group. Serum IL-4, IL-10, IL-6, IL-17, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) levels were measured in patients by enzyme-linked immunosorbent assay at 1, 3, and 5 days after admission. Furthermore, risk factors for NPE were screened using multivariable logistic regression analysis. RESULTS:IL-6, TNF-α, IL-10, and interferon-γ (IFN-γ) levels in the NPE group were higher than in the CNSD group. TNF-α, IL-10, and IFN-γ levels reached a peak on the 3rd day of admission. Age, continuous fever, blood sugar, white blood cell count, and IL-10 were risk factors for the occurrence of NPE in severe HFMD. CONCLUSION:The dynamic unbalance of inflammatory cytokines is related to the occurrence and progress of NPE.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Sun JF,Li HL,Sun BXdoi
10.1186/s40001-018-0313-1subject
Has Abstractpub_date
2018-05-03 00:00:00pages
21issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-018-0313-1journal_volume
23pub_type
杂志文章abstract：BACKGROUND:Chondral or osteochondral lesions, post-traumatic contracture and loose bodies of the elbow are often associated with chronic pain, stiffness, repetitive swelling and joint blockages. Therefore, arthroscopy of the elbow is often used in the elderly for the treatment of osteochondral defects or arthrolysis. T...
journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
pub_type： 杂志文章
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-6-258
更新日期：2011-06-21 00:00:00
abstract：:Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-02-25 00:00:00
abstract：BACKGROUND:Prostate cancer (PCa) originating from the prostate base may intrude into the urinary bladder and may be misdiagnosed as bladder cancer. In this retrospective study, we reviewed the clinic data on PCa cases which were initially misdiagnosed as bladder cancer in order to identify diagnostic methods that would...
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-05-26 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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