Abstract:
OBJECTIVE:The aim of this study was to examine the influence of immuno modulating agents like bromelain and trypsin (e.g. Wobenzym on granulocyte and monocyte functions in healthy volunteers and patients with disorders of the humoral immuno system X-linked agammaglobulinaemia (XLA) and common variable immuno deficiency (CVID) and to find out whether the unspecific immunity could be improved by these enzymes. METHODS:In a whole-blood assay kinetics of phagocytosis, respiratory burst and killing (PBK) were measured in blood samples incubated with and without bromelain and trypsin (B/T) using Candida albicans as target organism. The time-reaction curves were analysed determining their gradient (T1) and their onset (T2) as well as the half effect time (HET). RESULTS:Phagocytes from patients with XLA showed a significantly accelerated basal phagocytosis (reduction of HET by 24% p < 0.001) compared to healthy controls. After incubation with B/T (10 microg/ml each) speed of phagocytosis was nearly doubled (phagocyte activity p < 0.0001, Candida uptake p < 0.003), T2 of respiratory burst was reduced by 65 % (p < 0.0001) and killing was accelerated by 27% (p < 0.046). However, the maximal activities of all kinetics were not altered. Incubation of phagocytes from healthy controls with B/T accelerated phagocytosis to a level comparable to that of untreated phagocytes from patients with XLA and also accelerated reactive oxygen species (ROS) production (reduction of HET by 28%, p < 0.012). In contrast to phagocytes from patients with XLA, phagocytes of patients with CVID showed a similar stimulation by B/T like healthy controls. Further experiments with the single substances showed that bromelain was the active compound. CONCLUSION:Our data suggest, that bromelain possesses immuno stimulatory properties. Phagocytes of XLA patients appear to be particularly susceptible to this stimulation.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Brakebusch M,Wintergerst U,Petropoulou T,Notheis G,Husfeld L,Belohradsky BH,Adam Dsubject
Has Abstractpub_date
2001-05-29 00:00:00pages
193-200issue
5eissn
0949-2321issn
2047-783Xjournal_volume
6pub_type
杂志文章abstract::The prevalence of high plasmatic levels of homocysteine in hypertensive patients with mild renal dysfunction (MRD) defined by 2003 European Hypertension Society Guidelines (men plasmatic creatinine between 1.3 and 1.5; women plasmatic creatinine between 1.2 and 1.4 mg/dl) has not been previously reported. To evaluate ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-05-26 00:00:00
abstract:BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:2005-07-29 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN:This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio grou...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0285-6
更新日期:2017-10-18 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1996-03-19 00:00:00
abstract:OBJECTIVES:Several epidemiological studies address psychosomatic self regulation as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and recognized to be associated with better survival of cancer patients, it is unclear what the self regulati...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-5-223
更新日期:2009-05-14 00:00:00
abstract:INTRODUCTION:In utero and/or childhood environmental tobacco smoke exposure is well known to adversely affect lung function and to depreciate child's health in many ways. Fewer studies have assessed the long-term effects on COPD development and disease severity in later adulthood. METHODS:COPD patients were interviewe...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-s4-27
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-s2-92
更新日期:2010-11-04 00:00:00
abstract::Drug development in the field of HIV treatment is rapid. New nucleoside analogues (NRTI), non-nucleoside analogue reverse transcriptase inhibitors (NNRTI), and protease inhibitors (PI) are currently being investigated in human trials. Furthermore, inhibitors of HIV attachment, fusion and integrase with novel modes of ...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:2007-10-15 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-12-14 00:00:00
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journal_title:European journal of medical research
pub_type: 社论
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2000-04-19 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-019-0396-3
更新日期:2019-11-26 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,多中心研究
doi:10.1186/s40001-017-0277-6
更新日期:2017-09-29 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-11-461
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-08-18 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-22 00:00:00
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2001-01-29 00:00:00
abstract:BACKGROUND:The literature did not show clearly if a correlation between trunk and facial asymmetry exists. The aim of this study was to verify the association between trunk and facial asymmetries, and trunk and facial sagittal configuration in adolescents. METHODS:This is a cross-sectional screening study. It was carr...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0280-y
更新日期:2017-09-29 00:00:00
abstract:BACKGROUND:Renal impairment is a common complication of multiple myeloma occurring in up to 50 % of patients at some stage in their disease. Due to occurrence of cast nephropathies we hypothesized circulatory dysregulation (vasoconstriction) in the kidneys with measurable elevation of the resistance index among these p...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-5-210
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journal_title:European journal of medical research
pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 杂志文章,评审
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更新日期:2010-11-04 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-43
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abstract::In the treatment of pulmonary diseases the inhalation of aerosols plays a key role - it is the preferred route of drug delivery in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. But, in contrast to oral and intravenous administration drug delivery to the lungs is controlled by additional par...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
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更新日期:2009-12-07 00:00:00
abstract:PURPOSE:In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compa...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0265-x
更新日期:2017-07-06 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-11-20 00:00:00
abstract::A 70-year-old woman with a progressive dominant hemisphere syndrome but only mild hemiparesis and a normal brain scan (>3 hours from stroke onset) showed angiographic occlusion of the left anterior cerebral artery and the middle cerebral artery at its trifurcation with preservation of the rolandic artery. Intra-arteri...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2000-07-19 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-016-0232-y
更新日期:2016-10-12 00:00:00
abstract::Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sle...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-s2-193
更新日期:2010-11-04 00:00:00