Abstract:
:The purpose of the present study was to evaluate clinically the effect of an anaesthetic gel (lidocaine 20 mg/g as active agent) on pain sensitivity and early wound healing following nonsurgical periodontal therapy. A total of 40 patients with chronic periodontitis were enrolled in this randomized, split-mouth, double-blind, placebo-controlled clinical trial. Each subject had 3 sites in each of 2 contra-lateral jaw quadrants with a probing pocket depth (PPD) of > or = 5 mm and bleeding on probing (BOP+). All experimental sites received scaling and root planing without local anesthesia followed by irrigation with sterile saline and assessment of pain sensitivity using a standardized Visual Analogue Scale (VAS). After treatment, the patients randomly received the active or placebo gel into the periodontal pockets and overall pain was again assessed immediately after debridement and after 10, 20 and 30 minutes. The VAS showed a statistically significant (p < or = 0.0001) reduction in reported pain, favoring the active gel over the placebo at all 3 different points in time. After 30 minutes the median VAS score was 0.3 in the Dynexan group as opposed to 1.7 in the placebo-treated group (p < or = 0.0001). In terms of wound healing no differences were found between the test and control sites after 1 week. The results of the study showed that the anaesthetic gel was statistically more effective than the placebo in reducing pain following nonsurgical periodontal therapy. However, in terms of early wound healing no significant differences were seen between the two treatment sites.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Kasaj A,Heib A,Willershausen Bsubject
Has Abstractpub_date
2007-05-29 00:00:00pages
196-9issue
5eissn
0949-2321issn
2047-783Xjournal_volume
12pub_type
临床试验,杂志文章,随机对照试验abstract::Infectious diseases remain a major cause of morbidity and mortality in the year 2000. 17 million deaths per year or roughly a third of all deaths are caused by infections. Infectious diseases also pose a serious economic threat. While many well-established pathogens have not been contained several new infectious agent...
journal_title:European journal of medical research
pub_type: 总体
doi:
更新日期:2000-11-30 00:00:00
abstract:BACKGROUND:Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited. OBJECTIVE:To evaluate the response of HIV-infected patients with active syphilis to treatment with penicillin or ceftriaxone. - METHODS:A retrospective study involving 24 conse...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-2-47
更新日期:2011-02-24 00:00:00
abstract:OBJECTIVE:This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD). METHODS:A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-018-0313-1
更新日期:2018-05-03 00:00:00
abstract::While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2003-04-30 00:00:00
abstract::To investigate Candida epidemiology and immunologic correlates of protection in HIV-1 infected patients, we analyzed oral Candida colonization in correlation to the Candida-specific T-cell response measured by g-IFN ELISPOT using different Candida (C.) albicans strains. In 16/46 patients (13 asymptomatic, 3 with oral ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2006-11-30 00:00:00
abstract::A serological diagnosis (ELISA test) was carried out of infections by Helicobacter pylori in 1200 young males (recruits in the Polish Army) and the influence of selected epidemiologico-clinical factors (civil status, place of residence, profession, economical conditions, tobacco smoking, consumption of alcohol, diseas...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1997-08-28 00:00:00
abstract:BACKGROUND:Electroacupuncture is well known for its advantageous neuroanalgesic and therapeutic effects on myocardial ischemia-reperfusion injury. The purpose of the present research was to verify whether electroacupuncture can alleviate bupivacaine-induced myocardial injury. METHODS:Specific pathogen-free Wistar rats...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-020-00431-4
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Burkholderia cepacia strains have been known to possess the capability to cause serious infections especially in neonatal intensive care units (NICUs), and their multi-drug resistances become a severe threat in hospital settings. The aim of this investigation was to evaluate the B. cepacia complex infections...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-12-537
更新日期:2011-12-02 00:00:00
abstract:OBJECTIVES:Several epidemiological studies address psychosomatic self regulation as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and recognized to be associated with better survival of cancer patients, it is unclear what the self regulati...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-5-223
更新日期:2009-05-14 00:00:00
abstract::Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-02-25 00:00:00
abstract:BACKGROUND:Patients with congenital absence of the portal vein (CAPV) often suffer from additional medical complications such as hepatic tumors and cardiac malformations. CASE PRESENTATION:Congenital absence of the portal vein (CAPV) is a rare malformation. We present a case of a 16-year-old Chinese girl with CAPV wit...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:10.1186/s40001-014-0063-7
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:miRNAs are a class of small non-coding RNA molecules that play an important role in the pathogenesis of human diseases through negative regulation of gene expression. Although miRNA-10b (miR-10b) has been implicated in other tumors, its role in non-small cell lung cancer (NSCLC) is still unknown. The aim of ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-41
更新日期:2013-11-12 00:00:00
abstract:BACKGROUND:International guidelines for the treatment of HIV-1 infected children recommend efavirenz plus nucleoside reverse transcriptase inhibitor combination therapy for first line therapy. Until now little is known about the steady state pharmacokinetics of efavirenz in children. METHODS:11 HIV-1 infected children...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2006-09-29 00:00:00
abstract::Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1998-02-21 00:00:00
abstract:BACKGROUND:Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for di...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0300-y
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:In intestinal epithelium, tyrosine kinase receptor Ephrin B3 (Eph B3) maintains the architecture of the crypt-villus axis by repulsive interaction with its ligand ephrin-B1. While loss of Eph B3 is linked to colorectal cancer initiation, overexpression of Eph B3 in cancer cell lines inhibits growth and induc...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-17-10
更新日期:2012-05-14 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN:This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio grou...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0285-6
更新日期:2017-10-18 00:00:00
abstract::Photoplethysmography enables non-invasive investigation of the volume pulse in the microvasculature of patients. We previously have shown that time-discrete analysis enables identification of highly reproducible characteristics of the volume pulse in absolute values. The method would be of particular interest, if the ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1998-05-12 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN:Randomised, double blind, placebo-controlled clinical trial. SETTING:Tertiary university clinic. SUBJECTS...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2006-08-30 00:00:00
abstract::In the course of infection by the Human Immunodeficiency Virus (HIV) typical changes of inflammatory periodontal diseases can arise. The prevalence of these illnesses may be up to 5%. The HIV-associated periodontal diseases include linear gingival erythema (LGE), necrotizing ulcerative gingivitis (NUG) and necrotizing...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-26 00:00:00
abstract:OBJECTIVE:The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). METHODS:Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF,...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0194-5
更新日期:2016-01-08 00:00:00
abstract:OBJECTIVES:To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION:A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:10.1186/s40001-017-0295-4
更新日期:2017-12-02 00:00:00
abstract:BACKGROUND:The pathogenesis of central retinal artery occlusions (CRAO) varies, depending upon the underlying disease. An embolic origin of an occlusion often occurs. PATIENT AND METHODS:A 50-year-old man with an occlusion of the left internal carotid artery was examined because of a left central retinal artery occlus...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2000-04-19 00:00:00
abstract:BACKGROUND:Dopamine agonists (DA) are the first-choice drug for treatment of the early stage of Parkinson's disease (PD) in subjects younger than 70 years. Recently, a number of third generation DA have been marketed, including transdermal patch of rotigotine and extended release oral formulation of ropinirole and pram...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-60
更新日期:2013-12-21 00:00:00
abstract:BACKGROUND:Prophylaxis efforts for the maintenance of tooth health led to a distinctive decrease in caries frequency with children and young persons. Because the toothbrush can still be described as the most important oral hygiene aid, possible differences between the effectivity of electric and manual toothbrushes sho...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2001-01-29 00:00:00
abstract:OBJECTIVE:To report on radiological and epidemiological characteristics of pulmonary disease in patients with HIV infection in times of highly active antiretroviral therapy (HAART). METHODS:Clinical data of 130 HIV infected adults with acute pulmonary symptoms were compared with findings in chest radiography (n = 130)...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-08-16 00:00:00
abstract:OBJECTIVE:B7-H4, a member of the B7 family of immunoregulatory receptors, may participate in the negative regulation of cell-mediated immunity. Aberrant B7-H4 expression is detected in some tumors and it plays a role in the occurrence and development of tumors. The aim of this study was to elucidate the functional and ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-7-295
更新日期:2011-07-25 00:00:00
abstract:BACKGROUND:To compare the effect of totally thoracoscopic with conventional, open repair of atrial septal defect. METHODS:Forty atrial septal defect cases were divided into two groups by surgical approach: totally thoracoscopic approach (group A, n = 20) and conventional open approach (group B, n = 20). In group A, su...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:10.1186/2047-783X-19-13
更新日期:2014-03-11 00:00:00
abstract::The authors report a large duodenal somatostatinoma, a very rare tumor entity. A 8.5 cm globular mass in the area of the unicate process of the pancreas was detected in a 45 year old caucasian female by computerized tomography. The patient had only mild complaints. Initial treatment consisted of right pancreatectomy w...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-03-29 00:00:00
abstract:BACKGROUND:This study is a pre-planned country-specific subanalysis of results in Germany from a multinational multicenter registry to prospectively assess real-world experience with caspofungin administered for treatment of proven or probable invasive aspergillosis (IA). METHODS:Data from patients treated with caspof...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-17-7
更新日期:2012-04-17 00:00:00