Abstract：
BACKGROUND:The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN:This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio group and were fed a single dose of diosgenin (200 mg/kg/day) suspended in 0.3% CMC. Twenty mice were assigned to the DHEA group and were fed a single dose of DHEA (1.25 mg/kg/day) suspended in 0.3% CMC. The remaining 20 mice were assigned to the old control group and were fed a single dose of 0.3% CMC. Three months later, the reproductive performance of these female mice was determined by evaluating ovarian follicles and oocyte number and quality in IVF and comparing age-matched and young controls. The impact of NOBOX, GDF9 and BMP15 mRNA expression was also evaluated. RESULTS:Diosgenin improves ovarian reserve in naturally aging mice in terms of increasing the number of primary follicles (P < 0.05) and serum levels of AMH (P < 0.05). CONCLUSIONS:Diosgenin could counteract age-associated ovarian dysfunction by improving the ovarian reserve in a natural aging mice model.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Shen M,Qi C,Kuang YP,Yang Y,Lyu QF,Long H,Yan ZG,Lu YYdoi
10.1186/s40001-017-0285-6subject
Has Abstractpub_date
2017-10-18 00:00:00pages
42issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-017-0285-6journal_volume
22pub_type
杂志文章abstract：:Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sle...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-193
更新日期：2010-11-04 00:00:00
abstract：OBJECTIVE:This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD). METHODS:A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0313-1
更新日期：2018-05-03 00:00:00
abstract：OBJECTIVES:At workplaces, organic solvents are often used as mixtures. Nevertheless, there is limited knowledge of their acute effects on human central nervous system. Here we report the effects of a toluene-acetone mixture. METHODS:In a parallel design, subgroups of 12 healthy men each were exposed to a mixture conta...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-09-12 00:00:00
abstract：BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-06-30 00:00:00
abstract：BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-07-29 00:00:00
abstract：:Five patients with non-cytotoxic drug-induced agranulocytosis were treated with recombinant human granulocyte-colony-stimulating factor (rh-G-CSF). The drugs involved were dipyrone, captopril, clozapine and carbimazole. Bone marrow examination revealed a depleted granulopoiesis with normal erythro- and megakaryocytopo...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1995-12-18 00:00:00
abstract：:Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-21 00:00:00
abstract：:Experiments in space have shown that T lymphocyte function is altered in more than 50% of space crew members. There is strong evidence that such effect is due to stress rather than to weightlessness per se. However the health of astronauts was never threatened so far. Experiments in-vitro with cultures of human periph...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-09-09 00:00:00
abstract：INTRODUCTION:In utero and/or childhood environmental tobacco smoke exposure is well known to adversely affect lung function and to depreciate child's health in many ways. Fewer studies have assessed the long-term effects on COPD development and disease severity in later adulthood. METHODS:COPD patients were interviewe...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-s4-27
更新日期：2009-12-07 00:00:00
abstract：OBJECTIVE:Evaluating the effects of prophylactic administration of IgM-enriched immunoglobulins (IVIG) on immunological- and clinical parameters in cardiac surgical patients. PATIENTS AND METHODS:41 patients were randomized to receive either an IgM-enriched immunoglobulin (Pentaglobin(R)) preparation (1,300 ml immunog...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-12-17 00:00:00
abstract：BACKGROUND:International guidelines for the treatment of HIV-1 infected children recommend efavirenz plus nucleoside reverse transcriptase inhibitor combination therapy for first line therapy. Until now little is known about the steady state pharmacokinetics of efavirenz in children. METHODS:11 HIV-1 infected children...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-09-29 00:00:00
abstract：BACKGROUND:Reporting of all serious adverse events (SAEs) is a requirement for regulatory approval of a drug. Can equally rigorous reporting standards be expected in studies of non-drug treatments and how can underreporting, if any, be detected and proven? Using data from our large-scale prospective cohort study of acu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2004-12-22 00:00:00
abstract：OBJECTIVE:Pulmonary cavitation is the classic hallmark of pulmonary tuberculosis (PTB) and is the site of very high mycobacterial burden associated with antimycobacterial drug resistance and treatment failure. The objective of this study was to investigate the relationship between re-treatment PTB and initial pulmonary...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0214-0
更新日期：2016-05-06 00:00:00
abstract：:Gadolinium chelates are widely used in magnetic resonance imaging as contrast medium in patients with nephropathy. However, only few studies have investigated the effect of gadolinium on serum creatinine concentration and estimated GFR as surrogate markers of renal function. This study was performed to evaluate the ef...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-04-20 00:00:00
abstract：BACKGROUND:Burkholderia cepacia strains have been known to possess the capability to cause serious infections especially in neonatal intensive care units (NICUs), and their multi-drug resistances become a severe threat in hospital settings. The aim of this investigation was to evaluate the B. cepacia complex infections...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-12-537
更新日期：2011-12-02 00:00:00
abstract：:In this study a potential influence of diatomaceus earth to lower blood cholesterol was investigated. During 12 weeks we monitored serum lipid concentrations in 19 healthy individuals with a history of moderate hypercholesterinemia (9 females, 10 males, aged 35 - 67 years). Individuals administered orally 250 mg diato...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-04-08 00:00:00
abstract：OBJECTIVE:The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail. METHODS:Human MSCs were isolated and cultivated onto the surface of a 3 x 3 mm porcine collagen I / III carrier. After incubation, cell cultur...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-1-35
更新日期：2010-01-29 00:00:00
abstract：:Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART, ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-22 00:00:00
abstract：PURPOSE:In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compa...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0265-x
更新日期：2017-07-06 00:00:00
abstract：BACKGROUND:Prosthetic joint infection (PJI) is a serious complication of orthopedic implant surgery. Treatment often includes the use of an antibiotic-loaded Polymethyl methacrylate (PMMA) bone cement spacer. Several antibiotics are commonly used for the preparation of these spacers, but due to the increasing number of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-020-00428-z
更新日期：2020-08-18 00:00:00
abstract：:Infant formulas containing medium chain triglycerides (MTC) have been used for the nutritional management of infants with fat malabsorption. The optimal proportion of MTC in the formula remains to be determined. Three infant formulas with varying proportion of MTC in the fat blend were studied in children with cystic ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-02-21 00:00:00
abstract：:The prevalence of high plasmatic levels of homocysteine in hypertensive patients with mild renal dysfunction (MRD) defined by 2003 European Hypertension Society Guidelines (men plasmatic creatinine between 1.3 and 1.5; women plasmatic creatinine between 1.2 and 1.4 mg/dl) has not been previously reported. To evaluate ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-05-26 00:00:00
abstract：BACKGROUND:Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure and thereby entails higher morbidity and mortality in trauma patients. Pro- and anti-inflammator...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-7-284
更新日期：2009-07-22 00:00:00
abstract：BACKGROUND:miRNAs are a class of small non-coding RNA molecules that play an important role in the pathogenesis of human diseases through negative regulation of gene expression. Although miRNA-10b (miR-10b) has been implicated in other tumors, its role in non-small cell lung cancer (NSCLC) is still unknown. The aim of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-41
更新日期：2013-11-12 00:00:00
abstract：BACKGROUND:Focal colorectal uptake in (18)FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluation and below which for individual assessment. PURPOSE:To determine the lowest maximum standar...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0195-z
更新日期：2016-01-09 00:00:00
abstract：BACKGROUND:Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk facto...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/s40001-017-0277-6
更新日期：2017-09-29 00:00:00
abstract：BACKGROUND:Processes of restenosis, following arterial injury, are complex involving different cell types producing various cytokines and enzymes. Among those enzymes, smooth muscle cell-derived matrix metalloproteinases (MMPs) are thought to take part in cell migration, degrading of extracellular matrix, and neointima...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-11-461
更新日期：2010-11-25 00:00:00
abstract：:Infectious diseases remain a major cause of morbidity and mortality in the year 2000. 17 million deaths per year or roughly a third of all deaths are caused by infections. Infectious diseases also pose a serious economic threat. While many well-established pathogens have not been contained several new infectious agent...
journal_title：European journal of medical research
pub_type： 总体
doi：
更新日期：2000-11-30 00:00:00
abstract：:A serological diagnosis (ELISA test) was carried out of infections by Helicobacter pylori in 1200 young males (recruits in the Polish Army) and the influence of selected epidemiologico-clinical factors (civil status, place of residence, profession, economical conditions, tobacco smoking, consumption of alcohol, diseas...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-08-28 00:00:00
abstract：BACKGROUND:The expression of heparanase (HPSE) was associated with postoperative metastatic recurrence in patients with hepatocellular carcinoma (HCC). The six E-box binding sites in the core promoter of the HPSE gene suggested that transcription factors of E-box such as upstream stimulatory factor (USF) might regulate...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0045-9
更新日期：2014-08-23 00:00:00
