Abstract：
:Infectious diseases remain a major cause of morbidity and mortality in the year 2000. 17 million deaths per year or roughly a third of all deaths are caused by infections. Infectious diseases also pose a serious economic threat. While many well-established pathogens have not been contained several new infectious agents have been discovered within the past 27 years which include rotavirus, legionella, HIV, ebola, campylobacter, helicobacter, nipah, HHV8, hepatitis C, and many others. Additionally many new pathogens have emerged as serious threats to the ever-growing number of immuno-compromised patients. Infectious etiologies have been found for many common diseases (certain leukemias, duodenal ulcers, etcetera). It is likely that infections are at least co-factors for many other diseases (transplant-associated atherosclerosis). Only specialized care and multi-disciplinary collaboration will enable us to cope with current problems and the inevitable emergence of new infectious diseases.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
subject
Has Abstractpub_date
2000-11-30 00:00:00pages
491-505issue
11eissn
0949-2321issn
2047-783Xjournal_volume
5pub_type
总体abstract：:A number of neurodegenerative diseases including Parkinson's disease (PD) have been shown to be associated with polymorphic variants of mitochondrial DNA. The A4336G mutation in the tRNA(Gln) gene was reported to occur at a higher frequency in individuals with Parkinson's disease and Alzheimer's disease (AD) than in a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-03-24 00:00:00
abstract：BACKGROUND:Sonography has become the imaging technique of choice for guiding intraoperative interventions in abdominal surgery. Due to artefacts from residual air content, however, videothoracoscopic and open intraoperative ultrasound-guided thermoablation of lung malignancies are impossible. Lung flooding is a new met...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-23
更新日期：2013-07-10 00:00:00
abstract：BACKGROUND:Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0365-x
更新日期：2019-01-28 00:00:00
abstract：:Among primary hepatic malignancies, sarcomas represent a minority of 2 %. Of those, primary hepatic angiosarcoma is the most common one. In the past its incidence has been related to the exposure of certain chemicals like thorotrast, vinyl-chloride or arsenic. - Patients suffering from this aggressive, highly vascular...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-12-14 00:00:00
abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-10-22 00:00:00
abstract：BACKGROUND:Coronavirus is challenging the global health care system from time to time. The pregnant state, with alterations in hormone levels and decreased lung volumes due to a gravid uterus and slightly immunocompromised state may predispose patients to a more rapidly deteriorating clinical course and can get a great...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/s40001-020-00439-w
更新日期：2020-09-04 00:00:00
abstract：BACKGROUND:Sepsis leads to severe inflammatory and cardiac dysfunction. This study aimed to explore the clinical value of miR-495 in sepsis, as well as its role in sepsis-induced inflammation and cardiac dysfunction. METHODS:105 sepsis patients were recruited; receiver operating characteristic (ROC) curve was plotted ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0396-3
更新日期：2019-11-26 00:00:00
abstract：BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-06-28 00:00:00
abstract：OBJECTIVE:The aim of this study was to examine the influence of immuno modulating agents like bromelain and trypsin (e.g. Wobenzym on granulocyte and monocyte functions in healthy volunteers and patients with disorders of the humoral immuno system X-linked agammaglobulinaemia (XLA) and common variable immuno deficiency...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-05-29 00:00:00
abstract：:Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan. On her admission to the hospital, she had a temperature of 38.2 degrees C with canker sore. Prior to the commencement of chemotherapy, peripher...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-03-31 00:00:00
abstract：:Acute liver failure represents one of the most challenging conditions in intensive care treatment. In most cases there is no causal medical therapy available for survive making the intensive care treatment as the most important management tool, as bridge to transplant or still the recovery of the liver! These patients...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-28 00:00:00
abstract：:Progressive infantile spastic tetraparesis spans a wide spectrum of partially rare differential diagnoses. Based on a clinical example the differential diagnostic thoughts are discussed in detail. Though juvenile motor neuron disease is a rare entity, it has to be kept in mind for differential diagnostics in cases of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-10-27 00:00:00
abstract：:Triple A (four A; Allgrove syndrome) syndrome is a an autosomal recessive disorder characterized by alacrimia, achalasia, adrenocortical insufficiency, and various neurological abnormalities. We report a case of triple A syndrome in a 14-year-old female patient together with oral manifestations. The importance of this...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-07-31 00:00:00
abstract：OBJECTIVE:Evaluating the effects of prophylactic administration of IgM-enriched immunoglobulins (IVIG) on immunological- and clinical parameters in cardiac surgical patients. PATIENTS AND METHODS:41 patients were randomized to receive either an IgM-enriched immunoglobulin (Pentaglobin(R)) preparation (1,300 ml immunog...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-12-17 00:00:00
abstract：:In the course of infection by the Human Immunodeficiency Virus (HIV) typical changes of inflammatory periodontal diseases can arise. The prevalence of these illnesses may be up to 5%. The HIV-associated periodontal diseases include linear gingival erythema (LGE), necrotizing ulcerative gingivitis (NUG) and necrotizing...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-26 00:00:00
abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are sporadic, acute worsening of symptoms. Identifying predictors of exacerbation frequency may facilitate medical interventions that reduce exacerbation frequency and severity. The objective of this study was to determine predictors of exacerbati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-19-18
更新日期：2014-04-08 00:00:00
abstract：:Soot FR 101, Printex 90 and Chrysotile B are frequently found in indoor air pollutants phagocytized by alveolar macrophages (AM) involved in inflammatory pulmonary processes as, e.g. in cytokine secretions. The transcription factor NF-kappaB has a role in the trans-duction pathway of proinflammatory cytokines like IL-...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-09-17 00:00:00
abstract：PURPOSE:Evaluation of MR-guided interstitial laser thermotherapy (ILT) of colorectal liver metastases under consideration of efficacy, safety and patient survival. MATERIALS AND METHODS:Sixty-six inoperable patients with a total of 117 colorectal liver metastases were treated with MR-guided laser therapy in 96 session...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-04-26 00:00:00
abstract：:Though AIDS-related morbidity and mortality are generally decreasing as a result of highly active antiretroviral therapy (HAART) and prevention of opportunistic infections, dual infection with HCV and HIV leads to an acceleration in the natural course of chronic hepatitis C (cHC) and worsening of associated liver dise...
journal_title：European journal of medical research
pub_type：
doi：
更新日期：2002-01-29 00:00:00
abstract：:We investigated the hypothesis that religious commitment could help counter general affective distress, accompanying depressive symptoms, in older age. A total of 34 older adults, all catholic believers, completed self-reported questionnaires on the presence of depressive symptoms, religiosity, health, worry, and the ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-9-401
更新日期：2011-09-12 00:00:00
abstract：SUBJECT:Recent studies have shown that smoking and drinking are associated with poorer outcomes in patients with cardiomyopathy. The purpose of this study was to determine all-cause mortality in dilated cardiomyopathy (DCM) associated with smoking and drinking. METHODS:An observational cohort study was undertaken in D...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0171-z
更新日期：2015-09-17 00:00:00
abstract：:Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-21 00:00:00
abstract：BACKGROUND:Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS:Ten human ce...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-8-337
更新日期：2010-08-20 00:00:00
abstract：BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-07-29 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the association between leisure-time physical activity (LPA) and the risk of metabolic syndrome (MS). METHODS:Prospective cohort studies of the association between LPA and the risk of MS were retrieved from the PubMed and Embase databases up to 12 August 2013. The sta...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析,收录出版
doi：10.1186/2047-783X-19-22
更新日期：2014-04-23 00:00:00
abstract：BACKGROUND:Serotonin (5-HT) and its receptors are present in central, the brain stem, and peripheral, the carotid body, tissues controlling the ventilatory responses to hypoxia. The exact action of serotonin and its nature are, however, unsettled. We hypothesized that the discrepant results on the ventilatory action of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-128
更新日期：2010-11-04 00:00:00
abstract：:Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-02-25 00:00:00
abstract：:Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-10-433
更新日期：2009-09-28 00:00:00
abstract：:Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. It is believed that its soluble form (sICAM-1) might be a serum parameter of inflammatory activity with possible relevance in granulomatous disorders. To evaluate this role we measured sICAM-1 by ELISA in serum and shedding of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-06-17 00:00:00
abstract：OBJECTIVE:Changes in therapeutic concepts can only be justified by a significant improvement of outcome parameters. Furthermore, detailed statistics of complications are needed to guarantee high quality of treatment. This study describes the new University of Munich Lung Cancer Group Database. METHODS:The MLCG-Databas...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-10-30 00:00:00
