Abstract：
SUBJECT:Recent studies have shown that smoking and drinking are associated with poorer outcomes in patients with cardiomyopathy. The purpose of this study was to determine all-cause mortality in dilated cardiomyopathy (DCM) associated with smoking and drinking. METHODS:An observational cohort study was undertaken in DCM patients from November 2003 to September 2011. A total of 1118 patients were enrolled, with a mean follow-up of 3.5 ± 2.3 years. Standard demographics were obtained, and transthoracic echocardiography and routine blood testing were performed shortly after admission. Outcome assessment was based on the all-cause death after admission. RESULTS:The patients were divided into three groups: non-smokers (n = 593), mild-to-moderate smokers (n = 159) and heavy smokers (n = 366). The all-cause mortality rates showed no differences between the three groups (23.8, 20.8 and 24 %, respectively; log-rank χ (2) = 1.281, P = 0.527). There was also no significant difference in mortality between non-drinkers (n = 747), mild drinkers (n = 142) and moderate drinkers (n = 229) (23.7, 23.2 and 22.3 %, respectively; log-rank χ (2) = 2.343, P = 0.310). In the Cox analysis, neither the smoking (HR 0.971, P = 0.663) nor the drinking status (HR 0.891, P = 0.140) was a significant independent predictor of all-cause mortality in patients with DCM. CONCLUSION:In conclusion, there were no significant differences in mortality between the smoking- and drinking-related patient groups, indicating no effect of smoking and drinking on all-cause mortality in patients with DCM in the present large-scale study.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Li X,Liu Y,Luo R,Li G,Luo P,Liu M,He T,Hua Wdoi
10.1186/s40001-015-0171-zsubject
Has Abstractpub_date
2015-09-17 00:00:00pages
78eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-015-0171-zjournal_volume
20pub_type
杂志文章abstract：:CMV infection is common in pediatric HIV-1 infected patients. We present a case report, to our knowledge the first pediatric patient, in which Addison-disease due to CMV was suspected during lifetime. We want to point out the importance of routine clinical and laboratory follow up once a HIV-1 infected child is shown ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-06-20 00:00:00
abstract：BACKGROUND:Resternotomy in cardiac surgery is considered a risk factor for postoperative complications. Previous studies have demonstrated an ambiguous relationship between resternotomy and clinical outcomes. Registry data from a mixed population of durable circulatory support devices suggest that history of cardiac su...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0289-2
更新日期：2017-11-15 00:00:00
abstract：BACKGROUND:Reporting of all serious adverse events (SAEs) is a requirement for regulatory approval of a drug. Can equally rigorous reporting standards be expected in studies of non-drug treatments and how can underreporting, if any, be detected and proven? Using data from our large-scale prospective cohort study of acu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2004-12-22 00:00:00
abstract：:HIV-1 protease inhibitors have contributed significantly to the reduction in morbidity and mortality associated with HIV-1 disease. Some of their clinical benefit may be attributed to inhibition of non-viral pathogen proteases and mammalian proteases involved in apoptosis. Our objective was to investigate the effect o...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-01-28 00:00:00
abstract：:The aim of the study was to investigate whether cholecystokinin, neurotensin, and cholinergic mechanisms act as mediators of bile salt-stimulated exocrine pancreatic secretion. Ten fasting healthy subjects provided with a double-lumen tube received 2, 4, and 6 g cattle bile and 200, 400, and 600 mg Na-taurodeoxycholat...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-03-26 00:00:00
abstract：:In 1973 copper-associated liver disease was first described in an Australian boy of non-Indian origin who died at the age of 15 months with liver cirrhosis. At necropsy the hepatic copper concentration was excessively high (> 300 mg/g dry weight). It was shown that the boy s disease was caused by consumption of copper...
journal_title：European journal of medical research
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-06-28 00:00:00
abstract：BACKGROUND:This study is a pre-planned country-specific subanalysis of results in Germany from a multinational multicenter registry to prospectively assess real-world experience with caspofungin administered for treatment of proven or probable invasive aspergillosis (IA). METHODS:Data from patients treated with caspof...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-17-7
更新日期：2012-04-17 00:00:00
abstract：BACKGROUND:Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS:Ten human ce...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-8-337
更新日期：2010-08-20 00:00:00
abstract：:Acute liver failure represents one of the most challenging conditions in intensive care treatment. In most cases there is no causal medical therapy available for survive making the intensive care treatment as the most important management tool, as bridge to transplant or still the recovery of the liver! These patients...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-28 00:00:00
abstract：BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-06-30 00:00:00
abstract：:As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-28 00:00:00
abstract：OBJECTIVE:To report on radiological and epidemiological characteristics of pulmonary disease in patients with HIV infection in times of highly active antiretroviral therapy (HAART). METHODS:Clinical data of 130 HIV infected adults with acute pulmonary symptoms were compared with findings in chest radiography (n = 130)...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-08-16 00:00:00
abstract：:Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer sur...
journal_title：European journal of medical research
pub_type： 社论
doi：10.1186/s40001-018-0359-0
更新日期：2019-01-03 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2007-05-29 00:00:00
abstract：BACKGROUND:Prosthetic joint infection (PJI) is a serious complication of orthopedic implant surgery. Treatment often includes the use of an antibiotic-loaded Polymethyl methacrylate (PMMA) bone cement spacer. Several antibiotics are commonly used for the preparation of these spacers, but due to the increasing number of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-020-00428-z
更新日期：2020-08-18 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-017-0295-4
更新日期：2017-12-02 00:00:00
abstract：OBJECTIVE:The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail. METHODS:Human MSCs were isolated and cultivated onto the surface of a 3 x 3 mm porcine collagen I / III carrier. After incubation, cell cultur...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-1-35
更新日期：2010-01-29 00:00:00
abstract：:Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-02-25 00:00:00
abstract：BACKGROUND:Graft-versus-host disease (GVHD) after liver and kidney transplantation has high mortality and causes diagnostic challenges. This study aims to describe the cytokine and human leukocyte antigen (HLA) profile in the GVHD after liver and kidney transplantation. METHODS:A high-throughput detection kit was appl...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0232-y
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-10-16 00:00:00
abstract：:Over the last years the reality surrounding HIV-infection has undergone a considerable change with regard to the life expectancy of patients, and the plans they can make for their lives. Because the majority of the HIV positive population is of reproductive age, one of these plans might be to have children, often as a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-07-30 00:00:00
abstract：BACKGROUND:Increasing rates of prosthetic joint infection (PJI) have presented challenges for general practitioners, orthopedic surgeons and the health care system in the recent years. The diagnosis of PJI is complex; multiple diagnostic tools are used in the attempt to correctly diagnose PJI. Evidence-based algorithms...
journal_title：European journal of medical research
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更新日期：2017-03-09 00:00:00
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journal_title：European journal of medical research
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doi：10.1186/s40001-015-0147-z
更新日期：2015-05-31 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-03-27 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
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更新日期：2010-11-04 00:00:00
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journal_title：European journal of medical research
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doi：10.1186/2047-783x-14-1-42
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journal_title：European journal of medical research
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doi：
更新日期：1999-01-26 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-11-28 00:00:00
