Abstract:
:Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP450) prompted us to study this combination. - Thirteen patients with incomplete suppression of plasma HIV-RNA were enrolled and treatment was started with nelfinavir 750 mg tid and saquinavir 400 mg bid. Saquinavir-dosage was escalated in weekly intervals to 400 mg tid and 600 mg tid, respectively. All doses were given with food, and plasma levels of saquinavir and nelfinavir were assessed 4 hours post-dosing after 1, 2, 3, 4 and 8 weeks. Treatment was considered virologically efficacious if HIV-viral load was reduced by at least 0.5 log10 from baseline. - Double protease inhibitor-treatment with nelfinavir and saquinavir was virologically efficacious in 5/13 (39%) patients after 4 weeks but only in 4/13 (31%) patients after 8 and 1/13 (8%) after 16 and 24 weeks, respectively. No statistical difference in plasma concentrations was observed when saquinavir was administered in increasing doses of 400 mg bid, 400 mg tid or 600 mg tid in combination with nelfinavir. 5/13 (39%) patients developed diarrhea (>4/d), no other serious side-effects were observed. By eight weeks, the mean CD4 count for all patients was significantly higher when compared to baseline. - In patients refractory to standard triple therapy the combination of nelfinavir and saquinavir showed significant elevation of CD4-count, but only short term virological efficacy in a minority of patients. Plasma concentrations of saquinavir could not be increased by weekly dose escalation of the drug from 400 mg bid to 600 mg tid. Saquinavir drug concentrations of 600 mg saquinavir tid and nelfinavir showed rather non-significant lower values when compared to historical controls treated with a double-dose 1200 mg saquinavir tid regimen alone. We conclude that in these patients the combination of nelfinavir plus saquinavir has no advantage in terms of increasing bioavailibility of saquinavir or virological efficacy. During short observation time a beneficial effect on CD4-count was observed.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Reiser M,Salzberger B,Stiepel A,Hoetelmans R,Diehl V,Fätkenheuer Gsubject
Has Abstractpub_date
1999-02-25 00:00:00pages
54-8issue
2eissn
0949-2321issn
2047-783Xjournal_volume
4pub_type
临床试验,杂志文章abstract:OBJECTIVE:replication of HIV-1 after cell entry is essentially dependent on the reverse transcriptase (RT). Antiretroviral drugs impairing the function of the RT currently aim at the polymerase subunit. One reason for failure of antiretroviral treatment is the evolvement of resistance-associated mutations in the viral ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-10-415
更新日期:2010-10-25 00:00:00
abstract:INTRODUCTION:Recombinant human growth hormone (r-hGH) has demonstrated efficacy in treating HIV-associated wasting (HAW), however, HAW has become less prominent since the introduction of highly active antiretroviral therapy (HAART). Recent studies suggest that patients receiving HAART may still experience HAW. We inves...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2002-03-28 00:00:00
abstract:AIM:Antiseptics are commonly used in clinical practice to disinfect tissue and to avoid infections. However, topical antiseptics are assumed to have an influence on skin microcirculation, per se. Thus, the aim of the study was to analyse the influence of topically applied antiseptics on the microcirculation of intact s...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2004-09-29 00:00:00
abstract:BACKGROUND/OBJECTIVE:The continuous interaction of blood with artificial contact surfaces under cardiopulmonary bypass can lead to a substantial damage of blood cells and plasma factors. Surface biopolymers in oxygenation systems can help increasing the hemocompatibility, often combined with anticoagulative agents such...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-07-30 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN:Randomised, double blind, placebo-controlled clinical trial. SETTING:Tertiary university clinic. SUBJECTS...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2006-08-30 00:00:00
abstract::Hemorrhage from esophageal varices is a life-threatening event in patients with liver cirrhosis. About 40% to 80% of the patients surviving the first bleeding suffer from a recurrence of variceal bleeding within one year. This high recurrence rate substantially contributes to the mortality in patients with liver cirrh...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-25 00:00:00
abstract:BACKGROUND:This study is a pre-planned country-specific subanalysis of results in Germany from a multinational multicenter registry to prospectively assess real-world experience with caspofungin administered for treatment of proven or probable invasive aspergillosis (IA). METHODS:Data from patients treated with caspof...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-17-7
更新日期:2012-04-17 00:00:00
abstract:BACKGROUND:Bone fracture is one of the most common physical injuries in which gene expression and the microenvironment are reprogramed to facilitate the recovery process. METHODS:By specific siRNA transfection and MTT assay, we evaluated the effects of metastasis-associated gene 1 (MTA1) in osteoblast growth. To show ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0084-x
更新日期:2015-02-03 00:00:00
abstract::The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to deter...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-3-106
更新日期:2009-03-17 00:00:00
abstract::Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan. On her admission to the hospital, she had a temperature of 38.2 degrees C with canker sore. Prior to the commencement of chemotherapy, peripher...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-03-31 00:00:00
abstract:OBJECTIVE:Evaluating the effects of prophylactic administration of IgM-enriched immunoglobulins (IVIG) on immunological- and clinical parameters in cardiac surgical patients. PATIENTS AND METHODS:41 patients were randomized to receive either an IgM-enriched immunoglobulin (Pentaglobin(R)) preparation (1,300 ml immunog...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-12-17 00:00:00
abstract::We report the case of a 64-year old woman with severe attacks of allergic alveolitis occurring frequently independent of a concrete place. These attacks were regularely preceded by diarrhoe. Laboratory data showed marked leukopenia and circulating Candida albicans (C.a.)-antigen. Bronchoalveolar lavage revealed an inc...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2000-03-27 00:00:00
abstract::Pentalogy of Fallot is a rare cyanotic congenital heart disease characterized by biventricular origin of the aorta above a large ventricular septal defect, obstruction of the pulmonary outflow, right ventricular hypertrophy (tetralogy of Fallot), and an atrial septal defect. Mortality due to syncope, arrhythmia or con...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-06-28 00:00:00
abstract:OBJECTIVE:Pulmonary cavitation is the classic hallmark of pulmonary tuberculosis (PTB) and is the site of very high mycobacterial burden associated with antimycobacterial drug resistance and treatment failure. The objective of this study was to investigate the relationship between re-treatment PTB and initial pulmonary...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-016-0214-0
更新日期:2016-05-06 00:00:00
abstract::Plexiform neurofibroma (PN) is a rare benign tumor and a special subtype of neurofibromatosis type 1 (NF1). Though the incidence is low, giant PN of the craniomaxillofacial region could result in severe hemifacial hypertrophy which is known as a typical manifestation of NF1 in young children. Here, we retrospectively ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-2-84
更新日期:2010-02-26 00:00:00
abstract::Endorectal ultrasonography (ERUS) and magnetic resonance imaging (MRI) allow exploring the morphology of the rectum in detail. Use of such data, especially assessment of the rectal wall, is an important tool for ascertaining the perianal fistula localization as well as stage of the cancer and planning it appropriate t...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:10.1186/s40001-014-0078-0
更新日期:2015-01-14 00:00:00
abstract::Infectious diseases remain a major cause of morbidity and mortality in the year 2000. 17 million deaths per year or roughly a third of all deaths are caused by infections. Infectious diseases also pose a serious economic threat. While many well-established pathogens have not been contained several new infectious agent...
journal_title:European journal of medical research
pub_type: 总体
doi:
更新日期:2000-11-30 00:00:00
abstract:BACKGROUND:miRNAs are a class of small non-coding RNA molecules that play an important role in the pathogenesis of human diseases through negative regulation of gene expression. Although miRNA-10b (miR-10b) has been implicated in other tumors, its role in non-small cell lung cancer (NSCLC) is still unknown. The aim of ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-41
更新日期:2013-11-12 00:00:00
abstract:OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...
journal_title:European journal of medical research
pub_type: 杂志文章,多中心研究
doi:10.1186/2047-783x-14-4-171
更新日期:2009-04-16 00:00:00
abstract::Tooth-colored resin-based restoration materials have gained enormous significance in recent decades. Since the composites presently available still evidence various weaknesses, intensive research continues concerning them. In this study we tested the biocompatibility of six resin-based materials (Charisma, Solitaire, ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1999-04-27 00:00:00
abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-08-17 00:00:00
abstract:BACKGROUND:Electroacupuncture is well known for its advantageous neuroanalgesic and therapeutic effects on myocardial ischemia-reperfusion injury. The purpose of the present research was to verify whether electroacupuncture can alleviate bupivacaine-induced myocardial injury. METHODS:Specific pathogen-free Wistar rats...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-020-00431-4
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for di...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0300-y
更新日期:2018-01-08 00:00:00
abstract:OBJECTIVE:Changes in therapeutic concepts can only be justified by a significant improvement of outcome parameters. Furthermore, detailed statistics of complications are needed to guarantee high quality of treatment. This study describes the new University of Munich Lung Cancer Group Database. METHODS:The MLCG-Databas...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-10-30 00:00:00
abstract:BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-06-28 00:00:00
abstract:BACKGROUND:Osteoporosis affects 200 million people worldwide and places an enormous economic burden on society. We aim to identify the feature genes that are related to osteoprotegerin in osteoporosis and to perform function analysis with DNA microarray from human bone marrow. METHODS:We downloaded the gene expression...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-15
更新日期:2013-06-03 00:00:00
abstract:BACKGROUND:The literature did not show clearly if a correlation between trunk and facial asymmetry exists. The aim of this study was to verify the association between trunk and facial asymmetries, and trunk and facial sagittal configuration in adolescents. METHODS:This is a cross-sectional screening study. It was carr...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0280-y
更新日期:2017-09-29 00:00:00
abstract:BACKGROUND:Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-019-0365-x
更新日期:2019-01-28 00:00:00
abstract:BACKGROUND:Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic in...
journal_title:European journal of medical research
pub_type: 杂志文章,meta分析
doi:10.1186/2047-783X-19-12
更新日期:2014-03-03 00:00:00
abstract:BACKGROUND:Graft-versus-host disease (GVHD) after liver and kidney transplantation has high mortality and causes diagnostic challenges. This study aims to describe the cytokine and human leukocyte antigen (HLA) profile in the GVHD after liver and kidney transplantation. METHODS:A high-throughput detection kit was appl...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-016-0232-y
更新日期:2016-10-12 00:00:00