Abstract：
OBJECTIVE:Changes in therapeutic concepts can only be justified by a significant improvement of outcome parameters. Furthermore, detailed statistics of complications are needed to guarantee high quality of treatment. This study describes the new University of Munich Lung Cancer Group Database. METHODS:The MLCG-Database contains all patients who underwent surgery for lung cancer at the Department of Surgery, University of Munich Medical Centre since 1978. Data were database recorded on the patient's ward, or directly imported from other departments performing medical examinations on the patient. Data could be entered online at the time of surgery in the operating room. Relevant information from the Munich Tumour Registry was imported via encrypted data communication. Both epidemiological background and influence of preoperative risk factors on morbidity and mortality as well as on long-term survival were analysed. RESULTS:Median follow-up time was 45 months (1-295 months). Overall 5- and 10-year survival was 36% and 28% respectively. Preoperative risk factors were arterial hypertension in 43% of patients, COPD in 34%, abuse of nicotine in 26% and therapy with corticosteroids in 25%. Surgical procedure consist of lobectomy or bilobectomy in 69%, pneumonectomy in 16% and lesser resections in 15%. Intra- and postoperative complications occurred in 1.4% and 32% of patients, respectively. CONCLUSIONS:This paper provides an overview of our MLCG-Database, which allows performing statistics for outcome analysis and quality management reports as well as medical assessment on a huge collection of patient data on a day-to-day basis. In addition, impact analysis of risk factors on postoperative morbidity and mortality as well as investigation of long-term survival underlines results reported internationally.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Kühnl A,Hocaoglu Y,Herzog M,Schmidt M,Hornung HM,Jauch KW,Hatz R,Graeb Csubject
Has Abstractpub_date
2007-10-30 00:00:00pages
520-6issue
10eissn
0949-2321issn
2047-783Xjournal_volume
12pub_type
杂志文章abstract：BACKGROUND:We aimed to analyze the association between hypertension and deep vein thrombosis (DVT) after orthopedic surgery. METHODS:Relevant studies were identified by a search of PubMed, Embase, China National Knowledge Infrastructure, Wanfang, the Chinese Biomedical Literature, and Weipu database until December 201...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/s40001-016-0207-z
更新日期：2016-03-22 00:00:00
abstract：:HIV-1 protease inhibitors have contributed significantly to the reduction in morbidity and mortality associated with HIV-1 disease. Some of their clinical benefit may be attributed to inhibition of non-viral pathogen proteases and mammalian proteases involved in apoptosis. Our objective was to investigate the effect o...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-01-28 00:00:00
abstract：BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant tumor syndrome predisposing to predominantly colorectal and endometrial cancer. In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MS...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-01-28 00:00:00
abstract：:Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer sur...
journal_title：European journal of medical research
pub_type： 社论
doi：10.1186/s40001-018-0359-0
更新日期：2019-01-03 00:00:00
abstract：:The gum resin of Boswellia serrata, known in Indian Ayurvedic system of medicine as Salai guggal, contains boswellic acids, which have been shown to inhibit leukotriene biosynthesis. In a double-blind, placebo-controlled study forty patients, 23 males and 17 females in the age range of 18 - 75 years having mean durati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-11-17 00:00:00
abstract：:As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-28 00:00:00
abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-10-22 00:00:00
abstract：BACKGROUND:A great variety of dental materials are now available for use in restorative treatments. Much attention has been devoted to physical and chemical properties, but the biological effects of these materials have been less frequently studied. AIM:The aim of this study is to test the influence of resin based res...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-10-29 00:00:00
abstract：:Exposure to high concentrations of oxygen is known to induce changes in lung function through effects on several pulmonary cell types, including alveolar macrophages (AM). In this study, we studied the in vitro effects of hyperoxia on the release of proinflammatory cytokines and the expression of surface receptors in ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-04-21 00:00:00
abstract：INTRODUCTION:Mitochondrial dysfunction plays a central role in the general pathogenesis of non-alcoholic fatty liver disease (NAFLD), increasing the risk of developing steatosis and subsequent hepatocellular inflammation. We aimed to assess hepatic mitochondrial function by a non-invasive (13)C-methionine breath test (...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-6-258
更新日期：2011-06-21 00:00:00
abstract：:The authors report a large duodenal somatostatinoma, a very rare tumor entity. A 8.5 cm globular mass in the area of the unicate process of the pancreas was detected in a 45 year old caucasian female by computerized tomography. The patient had only mild complaints. Initial treatment consisted of right pancreatectomy w...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-03-29 00:00:00
abstract：BACKGROUND:miRNAs are a class of small non-coding RNA molecules that play an important role in the pathogenesis of human diseases through negative regulation of gene expression. Although miRNA-10b (miR-10b) has been implicated in other tumors, its role in non-small cell lung cancer (NSCLC) is still unknown. The aim of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-41
更新日期：2013-11-12 00:00:00
abstract：:Targeted intrapulmonary delivery of drugs may reduce systemic toxicity, improve treatment efficacy, but inhaled drugs may also interfere with pulmonary surfactant function. We hypothesized that the lipophilic drug amphotericin B used to treat or prevent pulmonary infections with aspergillus species, might destroy surf...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-08-18 00:00:00
abstract：BACKGROUND:The purpose was to explore possible risk factors of facet joint violation induced by adjacent superior vertebral pedicle screw during the minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF). METHODS:A total of 69 patients with lumbar degenerative disease, who underwent MIS-TLIF were...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0174-9
更新日期：2015-09-24 00:00:00
abstract：OBJECTIVE:Identification of specific origin of lipid accumulation in the liver of patients with non-alcoholic fatty liver disease (NAFLD) is the most important step in preventing this condition. Because liver steatosis, in the obese patients without any systemic disease, can be graded easily by ultrasonography (US), we...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-02-26 00:00:00
abstract：BACKGROUND:Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure and thereby entails higher morbidity and mortality in trauma patients. Pro- and anti-inflammator...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-7-284
更新日期：2009-07-22 00:00:00
abstract：:A fifty-year-old female presented with a one month history of progressive dyspnea, productive cough, pain of elbows and knees, and 40°C fever despite antibiotic treatment. She has been diagnosed of bronchial asthma over 25 years before admission and oral and depot glucocorticosteroids as a long-term therapy was applie...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-92
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS:Ten human ce...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-8-337
更新日期：2010-08-20 00:00:00
abstract：BACKGROUND:Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0365-x
更新日期：2019-01-28 00:00:00
abstract：:In 1973 copper-associated liver disease was first described in an Australian boy of non-Indian origin who died at the age of 15 months with liver cirrhosis. At necropsy the hepatic copper concentration was excessively high (> 300 mg/g dry weight). It was shown that the boy s disease was caused by consumption of copper...
journal_title：European journal of medical research
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-06-28 00:00:00
abstract：:We report the case of a 64-year old woman with severe attacks of allergic alveolitis occurring frequently independent of a concrete place. These attacks were regularely preceded by diarrhoe. Laboratory data showed marked leukopenia and circulating Candida albicans (C.a.)-antigen. Bronchoalveolar lavage revealed an inc...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-03-27 00:00:00
abstract：AIM:The aim of the in vitro study was to examine the effect of estradiol and progesterone on the proliferation rate of human gingival fibroblasts (HGF) derived from a healthy and a diabetic (type II) individual. METHODS:In the first experiment, cells in the logarithmic proliferative phase were incubated with estradiol...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-12-09 00:00:00
abstract：BACKGROUND:Relatively large calcific tendinitis with persistent symptoms after extended periods of conservative treatment is an indication for operative therapy. Arthroscopy, as a treatment for calcific tendinitis of the hip abductors and calcinosis circumscripta, has been described previously; however, to our knowledg...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-49
更新日期：2013-11-23 00:00:00
abstract：:Over the last years the reality surrounding HIV-infection has undergone a considerable change with regard to the life expectancy of patients, and the plans they can make for their lives. Because the majority of the HIV positive population is of reproductive age, one of these plans might be to have children, often as a...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-07-30 00:00:00
abstract：:Among the 763 patients with ulcers and stomach cancer, including the control group of 586 blood donors, the search for a relationship between the spread of infection and the main blood groups was defined by the appearance of IgG against H. pylori in blood plasma (the ELISA test). The statistical analysis, however, did...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-03-19 00:00:00
abstract：:The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to deter...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-3-106
更新日期：2009-03-17 00:00:00
abstract：:We report the first case of a well defined extrinsic allergic alveolitis as a complication of sulfasalazine therapy in a patient treated for psoriatic arthritis. CT of the chest showed small nodular densities over both lungs, BAL demonstrated a highly active lymphocytic alveolitis and transbronchial biopsies revealed ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-11-20 00:00:00
abstract：BACKGROUND:Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic in...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/2047-783X-19-12
更新日期：2014-03-03 00:00:00
abstract：:The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of pati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-05-24 00:00:00
abstract：OBJECTIVES:At workplaces, organic solvents are often used as mixtures. Nevertheless, there is limited knowledge of their acute effects on human central nervous system. Here we report the effects of a toluene-acetone mixture. METHODS:In a parallel design, subgroups of 12 healthy men each were exposed to a mixture conta...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-09-12 00:00:00
