Abstract：
:Exposure to high concentrations of oxygen is known to induce changes in lung function through effects on several pulmonary cell types, including alveolar macrophages (AM). In this study, we studied the in vitro effects of hyperoxia on the release of proinflammatory cytokines and the expression of surface receptors in AM obtained from cynomolgus monkeys by bronchoalveolar lavage under general anesthesia. AM were exposed for 24 h to moderate (50% O(2)) or severe (95% O&sub2) hyperoxia in the absence or presence of LPS, and the release of IL-1beta, IL-6, and TNF-alpha was measured in culture supernatants by ELISA. In addition, the expression of the surface molecules HLA-DR, CD14, and CD11b was assessed by flow cytometry. Exposure to 95% O2 activated resting AM to produce significantly increased amounts of IL-1beta and IL-6. Moreover, hyperoxia amplified the release of TNF-alpha by LPS-stimulated AM in an oxygen tension-dependent manner. Finally, exposure to 95% O2 upregulated the expression of the adhesion molecule CD11b on AM, whereas the expression of HLA-DR and CD14 was not affected. These findings support the view that hyperoxia-induced activation of AM may represent an initial event in the proinflammatory sequence caused by hyperoxia.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Burges A,Allmeling A,Krombach Fsubject
Has Abstractpub_date
1997-04-21 00:00:00pages
149-54issue
4eissn
0949-2321issn
2047-783Xjournal_volume
2pub_type
杂志文章abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by T-cell-dependent B-cell activation and altered T-cell response. Co-stimulatory and co-inhibitory molecules regulate and exert T-cell differentiation, survival and cytokine production. CD134+ and PD-1+ T-cells in SLE patients are inc...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0385-6
更新日期：2019-07-22 00:00:00
abstract：BACKGROUND:The aim of the study was to test for human papilloma virus (HPV) infection and human telomerase RNA component (hTERC) gene amplification in tissues derived from esophageal cancer, in esophagus displaying atypical hyperplasia and in normal tissue, and to analyze the relationship between them and discuss wheth...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-11
更新日期：2013-05-01 00:00:00
abstract：AIM:We have investigated CsA induced liver hyperplasia to explore the potential effects on the immunogenicity of the regenerating liver within the clinical context of rejection after transplantation. MATERIALS AND METHODS:Flow cytometry analysis of hepatocytes, isolated 48 hours after 2/3 partial hepatectomy (PH2/3) o...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-04-30 00:00:00
abstract：BACKGROUND:More and more studies have confirmed that miRNAs play an important role in maintaining bone remodeling and bone metabolism. This study investigated the expression level of miR-206 in the serum of osteoporosis (OP) patients and explored the effect and mechanism of miR-206 on the occurrence and development of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-021-00480-3
更新日期：2021-01-18 00:00:00
abstract：BACKGROUND:Prophylaxis efforts for the maintenance of tooth health led to a distinctive decrease in caries frequency with children and young persons. Because the toothbrush can still be described as the most important oral hygiene aid, possible differences between the effectivity of electric and manual toothbrushes sho...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2001-01-29 00:00:00
abstract：AIM:Antiseptics are commonly used in clinical practice to disinfect tissue and to avoid infections. However, topical antiseptics are assumed to have an influence on skin microcirculation, per se. Thus, the aim of the study was to analyse the influence of topically applied antiseptics on the microcirculation of intact s...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2004-09-29 00:00:00
abstract：BACKGROUND:Melasma is a common hypermelanosis of the face. The use of a classical Q-switched ruby laser (QSRL) to treat melasma is discussed controversially and is associated with frequent adverse effects, such as hyper- or hypopigmentation. Recently a fractional-mode (FRx) QSRL was developed to minimize the adverse ef...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-43
更新日期：2013-11-14 00:00:00
abstract：:While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-04-30 00:00:00
abstract：INTRODUCTION:Azathioprine has variable efficacy in inflammatory bowel disease. Previous studies suggested that either neutropenia, an increase in the mean corpuscular volume, the assessment of thiopurine methyl-transferase activity or erythrocyte 6-thioguanine values might predict the treatment response. However, due t...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-12-07 00:00:00
abstract：BACKGROUND:Focal colorectal uptake in (18)FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluation and below which for individual assessment. PURPOSE:To determine the lowest maximum standar...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0195-z
更新日期：2016-01-09 00:00:00
abstract：:Progressive infantile spastic tetraparesis spans a wide spectrum of partially rare differential diagnoses. Based on a clinical example the differential diagnostic thoughts are discussed in detail. Though juvenile motor neuron disease is a rare entity, it has to be kept in mind for differential diagnostics in cases of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-10-27 00:00:00
abstract：:A serological diagnosis (ELISA test) was carried out of infections by Helicobacter pylori in 1200 young males (recruits in the Polish Army) and the influence of selected epidemiologico-clinical factors (civil status, place of residence, profession, economical conditions, tobacco smoking, consumption of alcohol, diseas...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-08-28 00:00:00
abstract：:The current report describes the experience from the Frankfurt AIDS Cohort Study with patients suffering from renal failure. The clinical data of 4993 HIV-infected patients between 1983 and 1998 were analyzed retrospectively. Patients were seen at least twice a year and clinical features, routine laboratory results, i...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-23 00:00:00
abstract：BACKGROUND:Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited. OBJECTIVE:To evaluate the response of HIV-infected patients with active syphilis to treatment with penicillin or ceftriaxone. - METHODS:A retrospective study involving 24 conse...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-2-47
更新日期：2011-02-24 00:00:00
abstract：:Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sle...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-193
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-03-26 00:00:00
abstract：:A fifty-year-old female presented with a one month history of progressive dyspnea, productive cough, pain of elbows and knees, and 40°C fever despite antibiotic treatment. She has been diagnosed of bronchial asthma over 25 years before admission and oral and depot glucocorticosteroids as a long-term therapy was applie...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-92
更新日期：2010-11-04 00:00:00
abstract：:Plexiform neurofibroma (PN) is a rare benign tumor and a special subtype of neurofibromatosis type 1 (NF1). Though the incidence is low, giant PN of the craniomaxillofacial region could result in severe hemifacial hypertrophy which is known as a typical manifestation of NF1 in young children. Here, we retrospectively ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-2-84
更新日期：2010-02-26 00:00:00
abstract：:We investigated the hypothesis that religious commitment could help counter general affective distress, accompanying depressive symptoms, in older age. A total of 34 older adults, all catholic believers, completed self-reported questionnaires on the presence of depressive symptoms, religiosity, health, worry, and the ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-9-401
更新日期：2011-09-12 00:00:00
abstract：OBJECTIVE:Pulmonary cavitation is the classic hallmark of pulmonary tuberculosis (PTB) and is the site of very high mycobacterial burden associated with antimycobacterial drug resistance and treatment failure. The objective of this study was to investigate the relationship between re-treatment PTB and initial pulmonary...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0214-0
更新日期：2016-05-06 00:00:00
abstract：BACKGROUND:A novel software ("Dynamic Coronary Roadmap") was developed, which offers a real-time, dynamic overlay of the coronary tree on fluoroscopy. Once the roadmap has been automatically generated during angiography it can be used for navigation during percutaneous coronary interventions (PCI). As a feasibility stu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0333-x
更新日期：2018-07-31 00:00:00
abstract：BACKGROUND:It is hitherto still questionable which of the physical properties of the bile fluid influence the outcome of extracorporeal shock wave lithotripsy (ESWL). METHODS:In this study the influence of the density and viscosity of bile simulating fluid on ESWL was tested in vitro by applying CsCl solutions of dens...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-01-19 00:00:00
abstract：:In ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-10-30 00:00:00
abstract：:Experiments in space have shown that T lymphocyte function is altered in more than 50% of space crew members. There is strong evidence that such effect is due to stress rather than to weightlessness per se. However the health of astronauts was never threatened so far. Experiments in-vitro with cultures of human periph...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-09-09 00:00:00
abstract：:The purpose of the present study was to evaluate clinically the effect of an anaesthetic gel (lidocaine 20 mg/g as active agent) on pain sensitivity and early wound healing following nonsurgical periodontal therapy. A total of 40 patients with chronic periodontitis were enrolled in this randomized, split-mouth, double...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2007-05-29 00:00:00
abstract：:Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer sur...
journal_title：European journal of medical research
pub_type： 社论
doi：10.1186/s40001-018-0359-0
更新日期：2019-01-03 00:00:00
abstract：:The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-1-42
更新日期：2009-01-28 00:00:00
abstract：AIM:The aim of the in vitro study was to examine the effect of estradiol and progesterone on the proliferation rate of human gingival fibroblasts (HGF) derived from a healthy and a diabetic (type II) individual. METHODS:In the first experiment, cells in the logarithmic proliferative phase were incubated with estradiol...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-12-09 00:00:00
abstract：:The gum resin of Boswellia serrata, known in Indian Ayurvedic system of medicine as Salai guggal, contains boswellic acids, which have been shown to inhibit leukotriene biosynthesis. In a double-blind, placebo-controlled study forty patients, 23 males and 17 females in the age range of 18 - 75 years having mean durati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-11-17 00:00:00
abstract：BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant tumor syndrome predisposing to predominantly colorectal and endometrial cancer. In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MS...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-01-28 00:00:00
