Abstract:
BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by T-cell-dependent B-cell activation and altered T-cell response. Co-stimulatory and co-inhibitory molecules regulate and exert T-cell differentiation, survival and cytokine production. CD134+ and PD-1+ T-cells in SLE patients are increased in SLE. The aim of this study was to characterize CD134+ and PD-1+CD4+ T-cells according to their ability to produce IFN-γ, IL-21 and IL-22 in SLE patients. METHODS:Peripheral blood of 39 SLE patients and 19 healthy controls (HC) was stimulated with phorbol myristate acetate (PMA) calcium ionophore (Ca-Io). The expression of IFN-γ, IL-21 and IL-22 T-cells within the CD134+ and PD-1+ T-cells was analyzed by flow cytometry. Disease activity was assessed by SLE Disease Activity Index. RESULTS:Peripheral unstimulated CD134+ and PD-1+ CD4+ T-cells were significantly increased in patients with lupus nephritis. Upon stimulation both, CD134+ and PD-1+ CD4+ T-cells, produced significantly less IFN-γ in SLE patients as compared to HC. The percentages of IL-22 within the CD134+CD4+ T-cells were also significantly decreased in SLE as compared to HC. CONCLUSION:CD134+ and PD-1+CD4+ T-cells have mainly a Th1 effector T-cell signature. A lower proportion produces also IL-21 and IL-22. The impaired capacity to produce IFN-γ and IL-22 in SLE patients may contribute to the pathogenesis of the disease.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Dolff S,Scharpenberg C,Specker C,Kribben A,Witzke O,Wilde Bdoi
10.1186/s40001-019-0385-6subject
Has Abstractpub_date
2019-07-22 00:00:00pages
24issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-019-0385-6journal_volume
24pub_type
杂志文章abstract:OBJECTIVE:Due to the side effects of antiretroviral therapy and long term survival there is an increasing concern of an elevated rate of cardiovascular diseases in HIV-infected patients. The present study analysed the cardiovascular risk profile and the probability of cardiovascular events in HIV-infected patients, due...
journal_title:European journal of medical research
pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1996-05-24 00:00:00
abstract::Antibiotic-resistant organisms causing both hospital- and community-acquired complicated skin and soft-tissue infections (cSSTI) are increasingly reported. A substantial medical and economical burden associated with MRSA colonisation or infection has been documented. The number of currently available appropriate antim...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
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journal_title:European journal of medical research
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVES:To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION:A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA...
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-7-292
更新日期:2010-01-01 00:00:00
abstract::A 65-year old woman with known history of reactive depression and failed suicide attempts ingested 7 mg digitoxin at 09.00 h. After vomiting 4 hours later, she reported the drug intake to her husband who thereupon summoned a physician. Arriving at 16.00 h, the physician was informed about the suicide attempt, but fail...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1996-11-25 00:00:00
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pub_type: 杂志文章,评审
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journal_title:European journal of medical research
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更新日期:2000-08-18 00:00:00
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2007-05-29 00:00:00
abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...
journal_title:European journal of medical research
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doi:
更新日期:2005-08-17 00:00:00
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journal_title:European journal of medical research
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doi:10.1186/2047-783X-17-7
更新日期:2012-04-17 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1996-03-19 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-09-12 00:00:00
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pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-03-26 00:00:00
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pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
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doi:
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
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更新日期:2002-07-24 00:00:00
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更新日期:2011-11-10 00:00:00
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journal_title:European journal of medical research
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更新日期:2000-07-19 00:00:00
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更新日期:2010-10-25 00:00:00
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journal_title:European journal of medical research
pub_type: 杂志文章
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更新日期:2009-07-22 00:00:00