Abstract：
AIM:The aim of the in vitro study was to examine the effect of estradiol and progesterone on the proliferation rate of human gingival fibroblasts (HGF) derived from a healthy and a diabetic (type II) individual. METHODS:In the first experiment, cells in the logarithmic proliferative phase were incubated with estradiol or progesterone at concentrations of 10, 50, and 100 microg/ml for 72 h. Beside the hormones, a glucose solution at a concentration of 200 mg/dl was added to the cell cultures in the second experiment in order to mimic a diabetic situation. The proliferation rate of the cells was determined by means of fluorescence activity of a redox indicator (Alamar Blue(R) Assay) added to the cell culture. Proliferation, expressed in relative fluorescence units (RFU), was determined after 24, 48, and 72 h. RESULTS:Progesterone at concentrations of 50 and 100 microg/ml significantly (Mann-Whitney-U-Test, p<0.05) reduced cellular growth in both cultures. Estradiol did not have a significant effect on cellular growth. The effect of progesterone was slightly reduced by glucose when cells from the healthy individual were used and remained almost unchanged with the cells from the diabetic patient. CONCLUSIONS:The results of the present study may help to understand the role of the female sex-hormones in the development of gingival and periodontal diseases during pregnancy. Further research work, however, is needed to elucidate the cellular mechanisms leading to the effects observed.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Christoffers AB,Kreisler M,Willershausen Bsubject
Has Abstractpub_date
2003-12-09 00:00:00pages
535-42issue
12eissn
0949-2321issn
2047-783Xjournal_volume
8pub_type
杂志文章abstract：:The gum resin of Boswellia serrata, known in Indian Ayurvedic system of medicine as Salai guggal, contains boswellic acids, which have been shown to inhibit leukotriene biosynthesis. In a double-blind, placebo-controlled study forty patients, 23 males and 17 females in the age range of 18 - 75 years having mean durati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-11-17 00:00:00
abstract：UNLABELLED:Prolonged immobilization of severely ill, bed-ridden patients results in formation of pressure ulcers following inappropriate tissue blood perfusion, and local activation of leukocyte - endothelial cell interactions (L/EC). Various treatment modalities were implemented to improve local microcirculation with ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-04-20 00:00:00
abstract：OBJECTIVE:The aim of this study was to examine the influence of immuno modulating agents like bromelain and trypsin (e.g. Wobenzym on granulocyte and monocyte functions in healthy volunteers and patients with disorders of the humoral immuno system X-linked agammaglobulinaemia (XLA) and common variable immuno deficiency...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-05-29 00:00:00
abstract：OBJECTIVE:given sparse research on the issue, this study sought to shed light upon the interactions of alexithymia, emotion processing, and social anxiety in adults with attention-deficit hyperactivity disorder (ADHD). SUBJECTS AND METHODS:73 German adults with ADHD according to DSM-IV diagnostic criteria participated...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-9-403
更新日期：2010-09-24 00:00:00
abstract：BACKGROUND:Prostate cancer (PCa) originating from the prostate base may intrude into the urinary bladder and may be misdiagnosed as bladder cancer. In this retrospective study, we reviewed the clinic data on PCa cases which were initially misdiagnosed as bladder cancer in order to identify diagnostic methods that would...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-36
更新日期：2013-10-03 00:00:00
abstract：BACKGROUND:Despite extensive research, the underlying pathological mechanisms of osteoporosis are not completely understood. Recent studies have indicated a distinct role for the IFN-β/STAT1 pathway in bone metabolism. An inhibitory effect of IFN-β on osteoclastogenesis has been detected and STAT1/2 has been shown to i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0074-4
更新日期：2015-01-07 00:00:00
abstract：INTRODUCTION:Azathioprine has variable efficacy in inflammatory bowel disease. Previous studies suggested that either neutropenia, an increase in the mean corpuscular volume, the assessment of thiopurine methyl-transferase activity or erythrocyte 6-thioguanine values might predict the treatment response. However, due t...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-12-07 00:00:00
abstract：:A 70-year-old woman with a progressive dominant hemisphere syndrome but only mild hemiparesis and a normal brain scan (>3 hours from stroke onset) showed angiographic occlusion of the left anterior cerebral artery and the middle cerebral artery at its trifurcation with preservation of the rolandic artery. Intra-arteri...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2000-07-19 00:00:00
abstract：BACKGROUND:This study investigates the effects of human bone marrow-derived mesenchymal stem cell (hMSC) on migration and proliferation ability of hepatocellular carcinoma (HCC) with high- and low-metastatic potential. METHODS:The hMSC and transforming growth factor-β1 (TGFβ-1) gene infected hMSC were co-cultured with...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0144-2
更新日期：2015-05-24 00:00:00
abstract：:Tooth-colored resin-based restoration materials have gained enormous significance in recent decades. Since the composites presently available still evidence various weaknesses, intensive research continues concerning them. In this study we tested the biocompatibility of six resin-based materials (Charisma, Solitaire, ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-04-27 00:00:00
abstract：:Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sle...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-193
更新日期：2010-11-04 00:00:00
abstract：:The authors report a large duodenal somatostatinoma, a very rare tumor entity. A 8.5 cm globular mass in the area of the unicate process of the pancreas was detected in a 45 year old caucasian female by computerized tomography. The patient had only mild complaints. Initial treatment consisted of right pancreatectomy w...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-03-29 00:00:00
abstract：BACKGROUND:During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-03-26 00:00:00
abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-10-22 00:00:00
abstract：BACKGROUND:To compare the effect of totally thoracoscopic with conventional, open repair of atrial septal defect. METHODS:Forty atrial septal defect cases were divided into two groups by surgical approach: totally thoracoscopic approach (group A, n = 20) and conventional open approach (group B, n = 20). In group A, su...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：10.1186/2047-783X-19-13
更新日期：2014-03-11 00:00:00
abstract：BACKGROUND:Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0365-x
更新日期：2019-01-28 00:00:00
abstract：OBJECTIVE:To report on radiological and epidemiological characteristics of pulmonary disease in patients with HIV infection in times of highly active antiretroviral therapy (HAART). METHODS:Clinical data of 130 HIV infected adults with acute pulmonary symptoms were compared with findings in chest radiography (n = 130)...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-08-16 00:00:00
abstract：BACKGROUND/OBJECTIVE:The continuous interaction of blood with artificial contact surfaces under cardiopulmonary bypass can lead to a substantial damage of blood cells and plasma factors. Surface biopolymers in oxygenation systems can help increasing the hemocompatibility, often combined with anticoagulative agents such...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-07-30 00:00:00
abstract：OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/2047-783x-14-4-171
更新日期：2009-04-16 00:00:00
abstract：BACKGROUND:The aim of the study was to test for human papilloma virus (HPV) infection and human telomerase RNA component (hTERC) gene amplification in tissues derived from esophageal cancer, in esophagus displaying atypical hyperplasia and in normal tissue, and to analyze the relationship between them and discuss wheth...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-11
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Increasing incidence of multidrug-resistant Mycobacterium tuberculosis infections is hampering global tuberculosis control efforts. Kuwait is a low-tuberculosis-incidence country, and ~ 1% of M. tuberculosis strains are resistant to rifampicin and isoniazid (MDR-TB). This study detected mutations in seven ge...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0397-2
更新日期：2019-12-05 00:00:00
abstract：:The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-1-42
更新日期：2009-01-28 00:00:00
abstract：:We investigated the hypothesis that religious commitment could help counter general affective distress, accompanying depressive symptoms, in older age. A total of 34 older adults, all catholic believers, completed self-reported questionnaires on the presence of depressive symptoms, religiosity, health, worry, and the ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-9-401
更新日期：2011-09-12 00:00:00
abstract：BACKGROUND:The immunological and clinical benefits of structured treatment interruptions (STIs) during primary HIV-1 infection remain largely unclear. PATIENTS AND METHODS:Eight patients identified during primary HIV-1 infection were immediately treated with HAART and underwent subsequent STIs after reaching complete ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-07-31 00:00:00
abstract：:Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhi...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2002-09-30 00:00:00
abstract：:The history and todays knowledge on the pathogenesis of arteriosclerosis emphasizing the importance of cholesterol concentration in plasma for the development of atherosclerosis is summarized. For proving the lipid hypothesis careful patient observation and new findings of molecular biology have added important inform...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-16 00:00:00
abstract：:In Germany during the past years about 200-250 HIV infected pregnant women delivered a baby per year, a number that is currently increasing. To determine the HIV-status early in pregnancy voluntary HIV-testing of all pregnant women is recommended in Germany and Austria as part of prenatal care. In those cases, where H...
journal_title：European journal of medical research
pub_type： 共识发展会议,杂志文章,评审
doi：
更新日期：2004-06-30 00:00:00
abstract：:Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-10-433
更新日期：2009-09-28 00:00:00
abstract：BACKGROUND:Patients with a simple transversal fracture of the olecranon are often treated with a tension band wiring (TBW), because it is known as a biomechanically appropriate and cost-effective procedure. Nevertheless, the technique is in detail more challenging than thought, resulting in a considerable high rate of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0392-7
更新日期：2019-10-08 00:00:00
abstract：BACKGROUND:Renal impairment is a common complication of multiple myeloma occurring in up to 50 % of patients at some stage in their disease. Due to occurrence of cast nephropathies we hypothesized circulatory dysregulation (vasoconstriction) in the kidneys with measurable elevation of the resistance index among these p...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-5-210
更新日期：2010-05-18 00:00:00
