Renal function and renotropic effects of secretin in cystic fibrosis.

Abstract:

:In ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1.73m2), whereas the glomerular filtration rate, measured by inulin clearance showed no difference. Renal plasma flow and the fractional reabsorption rates of electrolytes were similar in patients and controls. During secretin infusion renal plasma flow increased and the fractional reabsorption rates of electrolytes decreased in both groups. The patients had a increased metabolic clearance (2900 vs 1660 ml/min*m2) and endogenous production rate (9,9 vs 2,5 pmol/min*m2) of of secretin. In conclusion global renal function and electrolyte handling, in particular chloride permeability, are unchanged in cystic fibrosis. Individuals expressing the DF508 genotype showed a selective elevation of creatinine excretion and clearance. The secretion and metabolic clearance of secretin are increased in cystic fibrosis.

journal_name

Eur J Med Res

authors

Windstetter D,Schaefer F,Schärer K,Reiter K,Eife R,Harms HK,Bertele-Harms R,Fiedler F,Tsui LC,Reitmeir P,Horster M,Hadorn HB

subject

Has Abstract

pub_date

1997-10-30 00:00:00

pages

431-6

issue

10

eissn

0949-2321

issn

2047-783X

journal_volume

2

pub_type

杂志文章
  • Quantification of fecal alpha 1-antitrypsin excretion for assessment of inflammatory bowel diseases.

    abstract::Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...

    journal_title:European journal of medical research

    pub_type: 杂志文章,评审

    doi:

    authors: Becker K,Frieling T,Häussinger D

    更新日期:1998-02-21 00:00:00

  • Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway.

    abstract:BACKGROUND:Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase ...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/s40001-019-0365-x

    authors: Malsy M,Bitzinger D,Graf B,Bundscherer A

    更新日期:2019-01-28 00:00:00

  • Developing a risk prediction model for breast cancer: a Statistical Utility to Determine Affinity of Neoplasm (SUDAN-CA Breast).

    abstract:BACKGROUND:Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk facto...

    journal_title:European journal of medical research

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s40001-017-0277-6

    authors: Salih AM,Alam-Elhuda DM,Alfaki MM,Yousif AE,Nouradyem MM

    更新日期:2017-09-29 00:00:00

  • Serological IgG, IgM and IgA diagnosis and prognosis of mycobacterial diseases in routine practice.

    abstract::The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of pati...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Kaustová J

    更新日期:1996-05-24 00:00:00

  • Diatomaceous earth lowers blood cholesterol concentrations.

    abstract::In this study a potential influence of diatomaceus earth to lower blood cholesterol was investigated. During 12 weeks we monitored serum lipid concentrations in 19 healthy individuals with a history of moderate hypercholesterinemia (9 females, 10 males, aged 35 - 67 years). Individuals administered orally 250 mg diato...

    journal_title:European journal of medical research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Wachter H,Lechleitner M,Artner-Dworzak E,Hausen A,Jarosch E,Widner B,Patsch J,Pfeiffer K,Fuchs D

    更新日期:1998-04-08 00:00:00

  • Focal colorectal uptake in (18)FDG-PET/CT: maximum standard uptake value as a trigger in a semi-automated screening setting.

    abstract:BACKGROUND:Focal colorectal uptake in (18)FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluation and below which for individual assessment. PURPOSE:To determine the lowest maximum standar...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/s40001-016-0195-z

    authors: Luboldt W,Wiedemann B,Fischer S,Bodelle B,Luboldt HJ,Grünwald F,Vogl TJ

    更新日期:2016-01-09 00:00:00

  • IL-22 production of effector CD4+ T-cells is altered in SLE patients.

    abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by T-cell-dependent B-cell activation and altered T-cell response. Co-stimulatory and co-inhibitory molecules regulate and exert T-cell differentiation, survival and cytokine production. CD134+ and PD-1+ T-cells in SLE patients are inc...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/s40001-019-0385-6

    authors: Dolff S,Scharpenberg C,Specker C,Kribben A,Witzke O,Wilde B

    更新日期:2019-07-22 00:00:00

  • Determination of intrarenal resistance index (RI) in patients with multiple myeloma.

    abstract:BACKGROUND:Renal impairment is a common complication of multiple myeloma occurring in up to 50 % of patients at some stage in their disease. Due to occurrence of cast nephropathies we hypothesized circulatory dysregulation (vasoconstriction) in the kidneys with measurable elevation of the resistance index among these p...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/2047-783x-15-5-210

    authors: Schiemann U,Kaiser HC,Götzberger M,Schmidmaier R,Bantle F,Straka C

    更新日期:2010-05-18 00:00:00

  • The Munich Ankle Questionnaire (MAQ): a self-assessment tool for a comprehensive evaluation of ankle disorders.

    abstract:BACKGROUND:There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Furthermore, the majori...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/s40001-018-0344-7

    authors: Greve F,Braun KF,Vitzthum V,Zyskowski M,Müller M,Kirchhoff C,Biberthaler P,Beirer M

    更新日期:2018-09-28 00:00:00

  • In vivo-induction of antibodies to mistletoe lectin-1 and viscotoxin by exposure to aqueous mistletoe extracts: a randomised double-blinded placebo controlled phase I study in healthy individuals.

    abstract:BACKGROUND:Several studies have been performed in tumour patients to analyse the immunological response to mistletoe extracts. Considering the fact that these extracts are given subcutaneously in most instances, the kind of application resembles a typical immunization schedule. We therefore wanted to see how those extr...

    journal_title:European journal of medical research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Klein R,Classen K,Berg PA,Lüdtke R,Werner M,Huber R

    更新日期:2002-04-30 00:00:00

  • Toxoplasma gondii infection, atopy and autoimmune disease.

    abstract::While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Radon K,Dressel H,Windstetter D,Reichert J,Schmid M,Nowak D

    更新日期:2003-04-30 00:00:00

  • Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphoma in an HIV-infected patient.

    abstract::The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/2047-783x-14-1-42

    authors: Boban A,Radman I,Zadro R,Dubravcic K,Maretic T,Civljak R,Lisic M,Begovac J

    更新日期:2009-01-28 00:00:00

  • Serum levels of basic fibroblast growth factor in acute myocardial infarction.

    abstract::As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Cuevas P,Barrios V,Giménez-Gallego G,Martinez-Coso V,Cuevas B,Benavides J,Garcia-Segovia J,Asin-Cardiel E

    更新日期:1997-07-28 00:00:00

  • An immunocompetent migrant presenting with neurosyphilis with an unusual unilateral papillitis: a case report.

    abstract::Unilateral papillitis caused by Treponema pallidum was found in an immunocompetent homosexual patient with severe vision loss who had received previous antibiotics treatment. Syphilis-related ocular manifestation is more common in the early stages of the disease and it can be associated with a central nervous system l...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/2047-783X-17-3

    authors: Turchetti P,Pacella F,Pacella E,Mirisola C,Uccella I

    更新日期:2012-02-14 00:00:00

  • Variations of soluble intercellular cell adhesion molecule 1 (sICAM-1) in serum of adult volunteers.

    abstract::Soluble cell adhesion molecules such as sICAM-1 in serum and other biological fluids are suggested as being useful diagnostic parameters for a variety of diseases. Since increased concentrations during diseases are frequently less pronounced compared to other parameters, we tested whether it would be necessary to alig...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Rudloff S,Thomas C,Kunz C

    更新日期:1995-12-18 00:00:00

  • Digitoxin intoxication with lethal outcome.

    abstract::A 65-year old woman with known history of reactive depression and failed suicide attempts ingested 7 mg digitoxin at 09.00 h. After vomiting 4 hours later, she reported the drug intake to her husband who thereupon summoned a physician. Arriving at 16.00 h, the physician was informed about the suicide attempt, but fail...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Krappweis J,Petereit G,Justus J,Altmann E,Kirch W

    更新日期:1996-11-25 00:00:00

  • Strategy of treatment of submucosal gastric tumors.

    abstract:BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...

    journal_title:European journal of medical research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Sato T,Peiper M,Fritscher-Ravens A,Gocht A,Soehendra N,Knoefel WT

    更新日期:2005-07-29 00:00:00

  • Validation of the self regulation questionnaire as a measure of health in quality of life research.

    abstract:OBJECTIVES:Several epidemiological studies address psychosomatic self regulation as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and recognized to be associated with better survival of cancer patients, it is unclear what the self regulati...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/2047-783x-14-5-223

    authors: Büssing A,Girke M,Heckmann C,Schad F,Ostermann T,Kröz M

    更新日期:2009-05-14 00:00:00

  • Long term tidal breathing measurements in newborns: influence of a bias flow on ventilatory parameters.

    abstract::Long-term pneumotachographic measurements in newborns are hampered by the apparatus dead space, which can be functionally eliminated by a constant bias flow (flow-through technique). In a clinical study the influence of this bias flow was investigated. - In 80 infants (group 1:20 healthy controls, group 2: 30 infants ...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Windstetter D,Foitzik B,Schmalisch G,Wauer R

    更新日期:1999-01-26 00:00:00

  • Topical application of vitamin A reverses metaplasia of rat vaginal epithelium: a rapid and efficient approach to improve mucosal barrier function.

    abstract::Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We ...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Biesalski HK,Sobeck U,Weiser H

    更新日期:2001-09-28 00:00:00

  • Langerhans'-cell histiocytosis in 58 adults.

    abstract::Previous studies on Langerhans'-cell histiocytosis (LCH) were mostly retrospective and patients had been recruited over a long time period. The aim of the present study was to establish data on the clinical presentation, diagnosis and treatment of currently affected patients. Data on the clinical history, diagnostic w...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Götz G,Fichter J

    更新日期:2004-11-29 00:00:00

  • Intensive care management of acute liver failure.

    abstract::Acute liver failure represents one of the most challenging conditions in intensive care treatment. In most cases there is no causal medical therapy available for survive making the intensive care treatment as the most important management tool, as bridge to transplant or still the recovery of the liver! These patients...

    journal_title:European journal of medical research

    pub_type: 杂志文章,评审

    doi:

    authors: Saner FH,Kavuk I,Lang H,Stavrou G,Paul A,Doemland M,Malagó M,Broelsch CE

    更新日期:2004-05-28 00:00:00

  • Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.

    abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Hanisch F,Bau V,Zierz S

    更新日期:2005-08-17 00:00:00

  • Computed tomography and magnetic resonance imaging of multiple focal nodular hyperplasias of the liver with congenital absence of the portal vein in a Chinese girl: case report and review of the literature.

    abstract:BACKGROUND:Patients with congenital absence of the portal vein (CAPV) often suffer from additional medical complications such as hepatic tumors and cardiac malformations. CASE PRESENTATION:Congenital absence of the portal vein (CAPV) is a rare malformation. We present a case of a 16-year-old Chinese girl with CAPV wit...

    journal_title:European journal of medical research

    pub_type: 杂志文章,评审

    doi:10.1186/s40001-014-0063-7

    authors: Zhang K,Wang Q,Wang H,Ye H,Guo A,Duan W

    更新日期:2014-11-26 00:00:00

  • Interdisciplinary treatment of primary hepatic angiosarcoma: emergency tumor embolization followed by elective surgery.

    abstract::Among primary hepatic malignancies, sarcomas represent a minority of 2 %. Of those, primary hepatic angiosarcoma is the most common one. In the past its incidence has been related to the exposure of certain chemicals like thorotrast, vinyl-chloride or arsenic. - Patients suffering from this aggressive, highly vascular...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Matthaei H,Boelke E,Eisenberger CF,Alldinger I,Krieg A,Schmelzle M,Poremba C,Schellhammer F,Knoefel WT,Budach W,Peiper M

    更新日期:2007-12-14 00:00:00

  • The influence of restorative materials on marginal gingiva.

    abstract:BACKGROUND:A great variety of dental materials are now available for use in restorative treatments. Much attention has been devoted to physical and chemical properties, but the biological effects of these materials have been less frequently studied. AIM:The aim of this study is to test the influence of resin based res...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Willershausen B,Köttgen C,Ernst CP

    更新日期:2001-10-29 00:00:00

  • The stability of carbapenems before and after admixture to PMMA-cement used for replacement surgery caused by Gram-negative bacteria.

    abstract:BACKGROUND:Prosthetic joint infection (PJI) is a serious complication of orthopedic implant surgery. Treatment often includes the use of an antibiotic-loaded Polymethyl methacrylate (PMMA) bone cement spacer. Several antibiotics are commonly used for the preparation of these spacers, but due to the increasing number of...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/s40001-020-00428-z

    authors: Schmid M,Steiner O,Fasshold L,Goessler W,Holl AM,Kühn KD

    更新日期:2020-08-18 00:00:00

  • Alexithymia, emotion processing and social anxiety in adults with ADHD.

    abstract:OBJECTIVE:given sparse research on the issue, this study sought to shed light upon the interactions of alexithymia, emotion processing, and social anxiety in adults with attention-deficit hyperactivity disorder (ADHD). SUBJECTS AND METHODS:73 German adults with ADHD according to DSM-IV diagnostic criteria participated...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:10.1186/2047-783x-15-9-403

    authors: Edel MA,Rudel A,Hubert C,Scheele D,Brüne M,Juckel G,Assion HJ

    更新日期:2010-09-24 00:00:00

  • Ultrasonographic and biochemical evaluation of visceral obesity in obese women with non-alcoholic fatty liver disease.

    abstract:OBJECTIVE:Identification of specific origin of lipid accumulation in the liver of patients with non-alcoholic fatty liver disease (NAFLD) is the most important step in preventing this condition. Because liver steatosis, in the obese patients without any systemic disease, can be graded easily by ultrasonography (US), we...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Fenkci S,Rota S,Sabir N,Akdag B

    更新日期:2007-02-26 00:00:00

  • Diagnostics and treatment of HIV-discordant couples who wish to have children.

    abstract::Over the last years the reality surrounding HIV-infection has undergone a considerable change with regard to the life expectancy of patients, and the plans they can make for their lives. Because the majority of the HIV positive population is of reproductive age, one of these plans might be to have children, often as a...

    journal_title:European journal of medical research

    pub_type: 杂志文章

    doi:

    authors: Weigel MM,Kremer H,Sonnenberg-Schwan U,Gölz J,Gürtler L,Doerr HW,Brockmeyer NH

    更新日期:2001-07-30 00:00:00