Abstract：
INTRODUCTION:Azathioprine has variable efficacy in inflammatory bowel disease. Previous studies suggested that either neutropenia, an increase in the mean corpuscular volume, the assessment of thiopurine methyl-transferase activity or erythrocyte 6-thioguanine values might predict the treatment response. However, due to the conflicting results of the preceding studies there are yet no established laboratory values which allow an estimation of the clinical response. PATIENTS AND METHODS:45 patients with Crohn's disease and 39 patients with ulcerative colitis were enrolled in this retrospective evaluation. After a minimum of six months therapy with azathioprine patients in remission were compared with those who did not achieve a stable remission with respect to the number of leucocytes, lymphocytes, neutrophil granulocytes and the mean corpuscular volume. RESULTS:Patients who went into remission during treatment with azathioprine displayed significantly lower leukocyte counts if compared to patients who were not in remission (p = 0.004 in Crohn's disease and 0.003 in ulcerative colitis). A similar tendency was also observed with respect to the granulocyte count (p = 0.007 in Crohn's disease and 0.004 in ulcerative colitis). The mean corpuscular volume did not correlate with the response to purine analogues. DISCUSSION:The absolute leukocyte count and the percentage of granulocytes seem to predict the response to purine analogues in inflammatory bowel disease and possibly offers a feasible and cost effective diagnostic tool for the assessment of therapeutic efficacy. Subsequent preferably prospective studies should aim to define the optimal cut-off value for the leukocyte count.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Glas J,Török HP,Daczo J,Tonenchi L,Folwaczny M,Folwaczny Csubject
Has Abstractpub_date
2005-12-07 00:00:00pages
535-8issue
12eissn
0949-2321issn
2047-783Xjournal_volume
10pub_type
临床试验,杂志文章abstract：:We investigated the hypothesis that religious commitment could help counter general affective distress, accompanying depressive symptoms, in older age. A total of 34 older adults, all catholic believers, completed self-reported questionnaires on the presence of depressive symptoms, religiosity, health, worry, and the ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-9-401
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-02-26 00:00:00
abstract：BACKGROUND:To compare the effect of totally thoracoscopic with conventional, open repair of atrial septal defect. METHODS:Forty atrial septal defect cases were divided into two groups by surgical approach: totally thoracoscopic approach (group A, n = 20) and conventional open approach (group B, n = 20). In group A, su...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：10.1186/2047-783X-19-13
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abstract：BACKGROUND:Data on lung volumes and changes in flow-volume spirometry at high altitude are few and do not provide comprehensive assessment of the occurring changes. This study characterizes alterations of the forced expiratory flow-volume curve (FEFV-curve) and lung volumes at increasing altitude. METHODS:FEFV-curve a...
journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-12-31 00:00:00
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journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-02-25 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-26 00:00:00
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journal_title：European journal of medical research
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更新日期：2000-07-19 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/s40001-017-0245-1
更新日期：2017-03-09 00:00:00
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journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-11-20 00:00:00
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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更新日期：2003-03-27 00:00:00
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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journal_title：European journal of medical research
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doi：
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journal_title：European journal of medical research
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doi：
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