Abstract：
BACKGROUND:Increasing rates of prosthetic joint infection (PJI) have presented challenges for general practitioners, orthopedic surgeons and the health care system in the recent years. The diagnosis of PJI is complex; multiple diagnostic tools are used in the attempt to correctly diagnose PJI. Evidence-based algorithms can help to identify PJI using standardized diagnostic steps. METHODS:We reviewed relevant publications between 1990 and 2015 using a systematic literature search in MEDLINE and PUBMED. The selected search results were then classified into levels of evidence. The keywords were prosthetic joint infection, biofilm, diagnosis, sonication, antibiotic treatment, implant-associated infection, Staph. aureus, rifampicin, implant retention, pcr, maldi-tof, serology, synovial fluid, c-reactive protein level, total hip arthroplasty (THA), total knee arthroplasty (TKA) and combinations of these terms. RESULTS:From an initial 768 publications, 156 publications were stringently reviewed. Publications with class I-III recommendations (EAST) were considered. We developed an algorithm for the diagnostic approach to display the complex diagnosis of PJI in a clear and logically structured process according to ISO 5807. CONCLUSIONS:The evidence-based standardized algorithm combines modern clinical requirements and evidence-based treatment principles. The algorithm provides a detailed transparent standard operating procedure (SOP) for diagnosing PJI. Thus, consistently high, examiner-independent process quality is assured to meet the demands of modern quality management in PJI diagnosis.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Mühlhofer HM,Pohlig F,Kanz KG,Lenze U,Lenze F,Toepfer A,Kelch S,Harrasser N,von Eisenhart-Rothe R,Schauwecker Jdoi
10.1186/s40001-017-0245-1subject
Has Abstractpub_date
2017-03-09 00:00:00pages
8issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-017-0245-1journal_volume
22pub_type
杂志文章,meta分析abstract：BACKGROUND:Patients with a simple transversal fracture of the olecranon are often treated with a tension band wiring (TBW), because it is known as a biomechanically appropriate and cost-effective procedure. Nevertheless, the technique is in detail more challenging than thought, resulting in a considerable high rate of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0392-7
更新日期：2019-10-08 00:00:00
abstract：BACKGROUND:Renal impairment is a common complication of multiple myeloma occurring in up to 50 % of patients at some stage in their disease. Due to occurrence of cast nephropathies we hypothesized circulatory dysregulation (vasoconstriction) in the kidneys with measurable elevation of the resistance index among these p...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-5-210
更新日期：2010-05-18 00:00:00
abstract：BACKGROUND:Sepsis leads to severe inflammatory and cardiac dysfunction. This study aimed to explore the clinical value of miR-495 in sepsis, as well as its role in sepsis-induced inflammation and cardiac dysfunction. METHODS:105 sepsis patients were recruited; receiver operating characteristic (ROC) curve was plotted ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0396-3
更新日期：2019-11-26 00:00:00
abstract：:Endorectal ultrasonography (ERUS) and magnetic resonance imaging (MRI) allow exploring the morphology of the rectum in detail. Use of such data, especially assessment of the rectal wall, is an important tool for ascertaining the perianal fistula localization as well as stage of the cancer and planning it appropriate t...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-014-0078-0
更新日期：2015-01-14 00:00:00
abstract：:HIV-1 protease inhibitors have contributed significantly to the reduction in morbidity and mortality associated with HIV-1 disease. Some of their clinical benefit may be attributed to inhibition of non-viral pathogen proteases and mammalian proteases involved in apoptosis. Our objective was to investigate the effect o...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-01-28 00:00:00
abstract：:Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART, ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-22 00:00:00
abstract：:CCR5 receptor inhibitors are currently being introduced into clinical practice. In some instances treatment failure is related to the selection of pre-existing CXCR4-tropic minority virus strains. Up to date it is unclear whether the outgrowth of a CXCR4 using reservoir is associated with accelerated HIV-disease. In a...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-15 00:00:00
abstract：BACKGROUND:Increasing incidence of multidrug-resistant Mycobacterium tuberculosis infections is hampering global tuberculosis control efforts. Kuwait is a low-tuberculosis-incidence country, and ~ 1% of M. tuberculosis strains are resistant to rifampicin and isoniazid (MDR-TB). This study detected mutations in seven ge...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0397-2
更新日期：2019-12-05 00:00:00
abstract：UNLABELLED:Prolonged immobilization of severely ill, bed-ridden patients results in formation of pressure ulcers following inappropriate tissue blood perfusion, and local activation of leukocyte - endothelial cell interactions (L/EC). Various treatment modalities were implemented to improve local microcirculation with ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-04-20 00:00:00
abstract：:Basic research: Perfluorocarbons and the Pulmonary Surfactant System - Perfluorocarbons in the Treatment of Pneumonia - Inertance of the Respiratory System during Partial Liquid Ventilation - Alveolar Dead Space and Partial Liquid Ventilation - Partial Liquid Ventilation and Prevention of Cerebral Damage - New therapi...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-05-26 00:00:00
abstract：:As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-28 00:00:00
abstract：INTRODUCTION:Mitochondrial dysfunction plays a central role in the general pathogenesis of non-alcoholic fatty liver disease (NAFLD), increasing the risk of developing steatosis and subsequent hepatocellular inflammation. We aimed to assess hepatic mitochondrial function by a non-invasive (13)C-methionine breath test (...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-6-258
更新日期：2011-06-21 00:00:00
abstract：BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-07-29 00:00:00
abstract：:Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-07-28 00:00:00
abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-10-22 00:00:00
abstract：BACKGROUND:Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited. OBJECTIVE:To evaluate the response of HIV-infected patients with active syphilis to treatment with penicillin or ceftriaxone. - METHODS:A retrospective study involving 24 conse...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-2-47
更新日期：2011-02-24 00:00:00
abstract：:Triple A (four A; Allgrove syndrome) syndrome is a an autosomal recessive disorder characterized by alacrimia, achalasia, adrenocortical insufficiency, and various neurological abnormalities. We report a case of triple A syndrome in a 14-year-old female patient together with oral manifestations. The importance of this...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-07-31 00:00:00
abstract：BACKGROUND:Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for di...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0300-y
更新日期：2018-01-08 00:00:00
abstract：BACKGROUND:Coronavirus is challenging the global health care system from time to time. The pregnant state, with alterations in hormone levels and decreased lung volumes due to a gravid uterus and slightly immunocompromised state may predispose patients to a more rapidly deteriorating clinical course and can get a great...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/s40001-020-00439-w
更新日期：2020-09-04 00:00:00
abstract：BACKGROUND:This study investigates the effects of human bone marrow-derived mesenchymal stem cell (hMSC) on migration and proliferation ability of hepatocellular carcinoma (HCC) with high- and low-metastatic potential. METHODS:The hMSC and transforming growth factor-β1 (TGFβ-1) gene infected hMSC were co-cultured with...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0144-2
更新日期：2015-05-24 00:00:00
abstract：:The influence of heparin on Polymorphonuclear (PMN s) leukocytes was investigated using a new whole-blood cytofluorometric method (patent granted for the test with the number P 4334935.8-41) with Candida albicans and Staphylococcus aureus as test microorganisms. After comparing the effect of equal volumes of two widel...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-12-31 00:00:00
abstract：OBJECTIVE:The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail. METHODS:Human MSCs were isolated and cultivated onto the surface of a 3 x 3 mm porcine collagen I / III carrier. After incubation, cell cultur...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-1-35
更新日期：2010-01-29 00:00:00
abstract：OBJECTIVE:Pulmonary cavitation is the classic hallmark of pulmonary tuberculosis (PTB) and is the site of very high mycobacterial burden associated with antimycobacterial drug resistance and treatment failure. The objective of this study was to investigate the relationship between re-treatment PTB and initial pulmonary...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0214-0
更新日期：2016-05-06 00:00:00
abstract：SUBJECT:Recent studies have shown that smoking and drinking are associated with poorer outcomes in patients with cardiomyopathy. The purpose of this study was to determine all-cause mortality in dilated cardiomyopathy (DCM) associated with smoking and drinking. METHODS:An observational cohort study was undertaken in D...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0171-z
更新日期：2015-09-17 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN:Randomised, double blind, placebo-controlled clinical trial. SETTING:Tertiary university clinic. SUBJECTS...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2006-08-30 00:00:00
abstract：:Hemorrhage from esophageal varices is a life-threatening event in patients with liver cirrhosis. About 40% to 80% of the patients surviving the first bleeding suffer from a recurrence of variceal bleeding within one year. This high recurrence rate substantially contributes to the mortality in patients with liver cirrh...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-25 00:00:00
abstract：:Unilateral papillitis caused by Treponema pallidum was found in an immunocompetent homosexual patient with severe vision loss who had received previous antibiotics treatment. Syphilis-related ocular manifestation is more common in the early stages of the disease and it can be associated with a central nervous system l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-17-3
更新日期：2012-02-14 00:00:00
abstract：AIM:We have investigated CsA induced liver hyperplasia to explore the potential effects on the immunogenicity of the regenerating liver within the clinical context of rejection after transplantation. MATERIALS AND METHODS:Flow cytometry analysis of hepatocytes, isolated 48 hours after 2/3 partial hepatectomy (PH2/3) o...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-04-30 00:00:00
abstract：BACKGROUND:International guidelines for the treatment of HIV-1 infected children recommend efavirenz plus nucleoside reverse transcriptase inhibitor combination therapy for first line therapy. Until now little is known about the steady state pharmacokinetics of efavirenz in children. METHODS:11 HIV-1 infected children...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-09-29 00:00:00
abstract：:The gum resin of Boswellia serrata, known in Indian Ayurvedic system of medicine as Salai guggal, contains boswellic acids, which have been shown to inhibit leukotriene biosynthesis. In a double-blind, placebo-controlled study forty patients, 23 males and 17 females in the age range of 18 - 75 years having mean durati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-11-17 00:00:00
