Abstract：
:Previous studies on Langerhans'-cell histiocytosis (LCH) were mostly retrospective and patients had been recruited over a long time period. The aim of the present study was to establish data on the clinical presentation, diagnosis and treatment of currently affected patients. Data on the clinical history, diagnostic work-up and course of histologically confirmed LCH in 58 adults were obtained with the aid of a questionnaire. A differentiation of the patients (average age 43.5 +/- 7.7 years, 66% women, 34% men) by the various clinical forms, revealed single-organ involvement in 42 of the patients (72 %), and multisystem involvement in the remaining 16 patients (28%). In the 42 patients, who had involvement of a single system, 23 had pulmonary involvement only. Multilocular osseous involvement was observed in 9 patients. In both single-organ or multisystem LCH the most common affected site was pulmonary involvement (62%), followed by osseous (50%) and cutaneous involvement (15%). 51 patients (88%) were smokers or ex-smokers. Dyspnoea (60%) and cough (47%) were the most frequent initial symptoms. In adults with LCH the pulmonary system is most frequently involved, however almost one-third of the patients present with multisystem disease.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Götz G,Fichter Jsubject
Has Abstractpub_date
2004-11-29 00:00:00pages
510-4issue
11eissn
0949-2321issn
2047-783Xjournal_volume
9pub_type
杂志文章abstract：:Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-09-28 00:00:00
abstract：:Though AIDS-related morbidity and mortality are generally decreasing as a result of highly active antiretroviral therapy (HAART) and prevention of opportunistic infections, dual infection with HCV and HIV leads to an acceleration in the natural course of chronic hepatitis C (cHC) and worsening of associated liver dise...
journal_title：European journal of medical research
pub_type：
doi：
更新日期：2002-01-29 00:00:00
abstract：BACKGROUND:Processes of restenosis, following arterial injury, are complex involving different cell types producing various cytokines and enzymes. Among those enzymes, smooth muscle cell-derived matrix metalloproteinases (MMPs) are thought to take part in cell migration, degrading of extracellular matrix, and neointima...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-11-461
更新日期：2010-11-25 00:00:00
abstract：BACKGROUND:The aim of the study was to test for human papilloma virus (HPV) infection and human telomerase RNA component (hTERC) gene amplification in tissues derived from esophageal cancer, in esophagus displaying atypical hyperplasia and in normal tissue, and to analyze the relationship between them and discuss wheth...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-11
更新日期：2013-05-01 00:00:00
abstract：:Infant formulas containing medium chain triglycerides (MTC) have been used for the nutritional management of infants with fat malabsorption. The optimal proportion of MTC in the formula remains to be determined. Three infant formulas with varying proportion of MTC in the fat blend were studied in children with cystic ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-02-21 00:00:00
abstract：:More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-20 00:00:00
abstract：:Soot FR 101, Printex 90 and Chrysotile B are frequently found in indoor air pollutants phagocytized by alveolar macrophages (AM) involved in inflammatory pulmonary processes as, e.g. in cytokine secretions. The transcription factor NF-kappaB has a role in the trans-duction pathway of proinflammatory cytokines like IL-...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-09-17 00:00:00
abstract：OBJECTIVE:This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD). METHODS:A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0313-1
更新日期：2018-05-03 00:00:00
abstract：BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-07-29 00:00:00
abstract：OBJECTIVES:At workplaces, organic solvents are often used as mixtures. Nevertheless, there is limited knowledge of their acute effects on human central nervous system. Here we report the effects of a toluene-acetone mixture. METHODS:In a parallel design, subgroups of 12 healthy men each were exposed to a mixture conta...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2005-09-12 00:00:00
abstract：:The purpose of this report is to document a case of unsuspected ameloblastoma involving the right man dibular subpontic region in a 38-year-old Cambodian female patient. This lesion was purportedly preceded by multiple radiolucencies which were diagnosed as radicular cysts and treated a few times in the past years by ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-3-135
更新日期：2010-03-30 00:00:00
abstract：BACKGROUND:Focal colorectal uptake in (18)FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluation and below which for individual assessment. PURPOSE:To determine the lowest maximum standar...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-016-0195-z
更新日期：2016-01-09 00:00:00
abstract：:Endorectal ultrasonography (ERUS) and magnetic resonance imaging (MRI) allow exploring the morphology of the rectum in detail. Use of such data, especially assessment of the rectal wall, is an important tool for ascertaining the perianal fistula localization as well as stage of the cancer and planning it appropriate t...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/s40001-014-0078-0
更新日期：2015-01-14 00:00:00
abstract：BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-06-28 00:00:00
abstract：:In this study a potential influence of diatomaceus earth to lower blood cholesterol was investigated. During 12 weeks we monitored serum lipid concentrations in 19 healthy individuals with a history of moderate hypercholesterinemia (9 females, 10 males, aged 35 - 67 years). Individuals administered orally 250 mg diato...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-04-08 00:00:00
abstract：BACKGROUND:Resternotomy in cardiac surgery is considered a risk factor for postoperative complications. Previous studies have demonstrated an ambiguous relationship between resternotomy and clinical outcomes. Registry data from a mixed population of durable circulatory support devices suggest that history of cardiac su...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0289-2
更新日期：2017-11-15 00:00:00
abstract：BACKGROUND:Patients with human immunodeficiency virus (HIV) infection have an increased risk of cardiovascular diseases. Previous publications described pericardial effusion as one of the most common HIV-associated cardiac affiliations. The aim of the current study was to investigate if pericardial effusion still has a...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/2047-783x-16-11-480
更新日期：2011-11-10 00:00:00
abstract：:Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. It is believed that its soluble form (sICAM-1) might be a serum parameter of inflammatory activity with possible relevance in granulomatous disorders. To evaluate this role we measured sICAM-1 by ELISA in serum and shedding of...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1998-06-17 00:00:00
abstract：:Soluble cell adhesion molecules such as sICAM-1 in serum and other biological fluids are suggested as being useful diagnostic parameters for a variety of diseases. Since increased concentrations during diseases are frequently less pronounced compared to other parameters, we tested whether it would be necessary to alig...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1995-12-18 00:00:00
abstract：:CCR5 receptor inhibitors are currently being introduced into clinical practice. In some instances treatment failure is related to the selection of pre-existing CXCR4-tropic minority virus strains. Up to date it is unclear whether the outgrowth of a CXCR4 using reservoir is associated with accelerated HIV-disease. In a...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-15 00:00:00
abstract：:Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-02-25 00:00:00
abstract：:Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sle...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-s2-193
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:International guidelines for the treatment of HIV-1 infected children recommend efavirenz plus nucleoside reverse transcriptase inhibitor combination therapy for first line therapy. Until now little is known about the steady state pharmacokinetics of efavirenz in children. METHODS:11 HIV-1 infected children...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-09-29 00:00:00
abstract：INTRODUCTION:Mitochondrial dysfunction plays a central role in the general pathogenesis of non-alcoholic fatty liver disease (NAFLD), increasing the risk of developing steatosis and subsequent hepatocellular inflammation. We aimed to assess hepatic mitochondrial function by a non-invasive (13)C-methionine breath test (...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-6-258
更新日期：2011-06-21 00:00:00
abstract：:As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-28 00:00:00
abstract：BACKGROUND:Patients with a simple transversal fracture of the olecranon are often treated with a tension band wiring (TBW), because it is known as a biomechanically appropriate and cost-effective procedure. Nevertheless, the technique is in detail more challenging than thought, resulting in a considerable high rate of ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-019-0392-7
更新日期：2019-10-08 00:00:00
abstract：BACKGROUND:Despite extensive research, the underlying pathological mechanisms of osteoporosis are not completely understood. Recent studies have indicated a distinct role for the IFN-β/STAT1 pathway in bone metabolism. An inhibitory effect of IFN-β on osteoclastogenesis has been detected and STAT1/2 has been shown to i...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-014-0074-4
更新日期：2015-01-07 00:00:00
abstract：UNLABELLED:Prolonged immobilization of severely ill, bed-ridden patients results in formation of pressure ulcers following inappropriate tissue blood perfusion, and local activation of leukocyte - endothelial cell interactions (L/EC). Various treatment modalities were implemented to improve local microcirculation with ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2001-04-20 00:00:00
abstract：:Unilateral papillitis caused by Treponema pallidum was found in an immunocompetent homosexual patient with severe vision loss who had received previous antibiotics treatment. Syphilis-related ocular manifestation is more common in the early stages of the disease and it can be associated with a central nervous system l...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-17-3
更新日期：2012-02-14 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the association between leisure-time physical activity (LPA) and the risk of metabolic syndrome (MS). METHODS:Prospective cohort studies of the association between LPA and the risk of MS were retrieved from the PubMed and Embase databases up to 12 August 2013. The sta...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析,收录出版
doi：10.1186/2047-783X-19-22
更新日期：2014-04-23 00:00:00
