Abstract：
:A 65-year old woman with known history of reactive depression and failed suicide attempts ingested 7 mg digitoxin at 09.00 h. After vomiting 4 hours later, she reported the drug intake to her husband who thereupon summoned a physician. Arriving at 16.00 h, the physician was informed about the suicide attempt, but failed to initiate any specific measures. After a second doctor's visit at 22.00 h, the patient was rushed to hospital in a moribund state. In spite of a gastric lavage, treatment with activated charcoal and insertion of a transvenous pacemaker, the patient died at 23.45 h with signs of total atrioventricular block. Digitalis fab fragments could not be administered in time. A calculation based on the plasma digitoxin concentration of 212 ng.ml-1 measured at 23.00 h indicated that nearly the entire ingested dose had been absorbed. Thus, neither the vomiting nor the gastric lavage eliminated significant amounts of the drug which had left the stomach without delay. Under these circumstances, the failure to initiate timely therapy with specific digitalis fab fragments ultimately contributed to the lethal outcome.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Krappweis J,Petereit G,Justus J,Altmann E,Kirch Wsubject
Has Abstractpub_date
1996-11-25 00:00:00pages
551-3issue
12eissn
0949-2321issn
2047-783Xjournal_volume
1pub_type
杂志文章abstract：BACKGROUND:Relatively large calcific tendinitis with persistent symptoms after extended periods of conservative treatment is an indication for operative therapy. Arthroscopy, as a treatment for calcific tendinitis of the hip abductors and calcinosis circumscripta, has been described previously; however, to our knowledg...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-49
更新日期：2013-11-23 00:00:00
abstract：:Tooth-colored resin-based restoration materials have gained enormous significance in recent decades. Since the composites presently available still evidence various weaknesses, intensive research continues concerning them. In this study we tested the biocompatibility of six resin-based materials (Charisma, Solitaire, ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1999-04-27 00:00:00
abstract：BACKGROUND:Osteoporosis affects 200 million people worldwide and places an enormous economic burden on society. We aim to identify the feature genes that are related to osteoprotegerin in osteoporosis and to perform function analysis with DNA microarray from human bone marrow. METHODS:We downloaded the gene expression...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-15
更新日期：2013-06-03 00:00:00
abstract：BACKGROUND:A novel software ("Dynamic Coronary Roadmap") was developed, which offers a real-time, dynamic overlay of the coronary tree on fluoroscopy. Once the roadmap has been automatically generated during angiography it can be used for navigation during percutaneous coronary interventions (PCI). As a feasibility stu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-018-0333-x
更新日期：2018-07-31 00:00:00
abstract：:Infant formulas containing medium chain triglycerides (MTC) have been used for the nutritional management of infants with fat malabsorption. The optimal proportion of MTC in the formula remains to be determined. Three infant formulas with varying proportion of MTC in the fat blend were studied in children with cystic ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1997-02-21 00:00:00
abstract：:Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-21 00:00:00
abstract：:The introduction of integrase inhibitors as a new drug class for treatment of HIV have added a very potent and extremely well tolerated new treatment option to the HIV-armentarium. Particularly in patients with previously developed drug resistance, the availability of new active drugs offers great hope. Moreover, the ...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-14-s3-1
更新日期：2009-11-24 00:00:00
abstract：:More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-20 00:00:00
abstract：OBJECTIVE:replication of HIV-1 after cell entry is essentially dependent on the reverse transcriptase (RT). Antiretroviral drugs impairing the function of the RT currently aim at the polymerase subunit. One reason for failure of antiretroviral treatment is the evolvement of resistance-associated mutations in the viral ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-15-10-415
更新日期：2010-10-25 00:00:00
abstract：BACKGROUND:Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk facto...
journal_title：European journal of medical research
pub_type： 杂志文章,多中心研究
doi：10.1186/s40001-017-0277-6
更新日期：2017-09-29 00:00:00
abstract：BACKGROUND:Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for di...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-017-0300-y
更新日期：2018-01-08 00:00:00
abstract：BACKGROUND:This study investigates the effects of human bone marrow-derived mesenchymal stem cell (hMSC) on migration and proliferation ability of hepatocellular carcinoma (HCC) with high- and low-metastatic potential. METHODS:The hMSC and transforming growth factor-β1 (TGFβ-1) gene infected hMSC were co-cultured with...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0144-2
更新日期：2015-05-24 00:00:00
abstract：:The immunological environment of leukemic blasts in the bone marrow might play a decisive role in determining an individual's risk for relapse. In order to identify potential predictors of relapse and to elucidate the mechanisms of immune control of leukemic blasts we examined the expression of cytokines, costimulator...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2006-03-27 00:00:00
abstract：:Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to inhibition of metabolism by cytochrome P450 (CYP4...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-02-25 00:00:00
abstract：BACKGROUND:Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure and thereby entails higher morbidity and mortality in trauma patients. Pro- and anti-inflammator...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-14-7-284
更新日期：2009-07-22 00:00:00
abstract：BACKGROUND:Several studies have been performed in tumour patients to analyse the immunological response to mistletoe extracts. Considering the fact that these extracts are given subcutaneously in most instances, the kind of application resembles a typical immunization schedule. We therefore wanted to see how those extr...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-04-30 00:00:00
abstract：BACKGROUND:Prophylaxis efforts for the maintenance of tooth health led to a distinctive decrease in caries frequency with children and young persons. Because the toothbrush can still be described as the most important oral hygiene aid, possible differences between the effectivity of electric and manual toothbrushes sho...
journal_title：European journal of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2001-01-29 00:00:00
abstract：:The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of pati...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1996-05-24 00:00:00
abstract：:Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granu...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-07-28 00:00:00
abstract：:Right ventricle (RV) dysfunction is a key outcome determinant and a leading cause of death for patients with chronic thromboembolic pulmonary hypertension (CTEPH). In this report, we followed the 5-year clinical journey of a patient with CTEPH. The tricuspid pressure gradient was significantly increased in the early p...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0112-x
更新日期：2015-03-02 00:00:00
abstract：BACKGROUND:The aim of the study was to test for human papilloma virus (HPV) infection and human telomerase RNA component (hTERC) gene amplification in tissues derived from esophageal cancer, in esophagus displaying atypical hyperplasia and in normal tissue, and to analyze the relationship between them and discuss wheth...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783X-18-11
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:Changes in therapeutic concepts can only be justified by a significant improvement of outcome parameters. Furthermore, detailed statistics of complications are needed to guarantee high quality of treatment. This study describes the new University of Munich Lung Cancer Group Database. METHODS:The MLCG-Databas...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2007-10-30 00:00:00
abstract：INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2008-11-24 00:00:00
abstract：BACKGROUND:Bone fracture is one of the most common physical injuries in which gene expression and the microenvironment are reprogramed to facilitate the recovery process. METHODS:By specific siRNA transfection and MTT assay, we evaluated the effects of metastasis-associated gene 1 (MTA1) in osteoblast growth. To show ...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/s40001-015-0084-x
更新日期：2015-02-03 00:00:00
abstract：BACKGROUND:Postoperative hyperthyroidism occurs in approximately one third of patients following parathyroidectomy due to primary hyperparathyroidism (PHP), but has only rarely been described in secondary hyperparathyroidism (SHP). The frequency, course, and laboratory markers of postoperative hyperthyroidism in SHP re...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-8-375
更新日期：2011-08-08 00:00:00
abstract：INTRODUCTION:Mitochondrial dysfunction plays a central role in the general pathogenesis of non-alcoholic fatty liver disease (NAFLD), increasing the risk of developing steatosis and subsequent hepatocellular inflammation. We aimed to assess hepatic mitochondrial function by a non-invasive (13)C-methionine breath test (...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：10.1186/2047-783x-16-6-258
更新日期：2011-06-21 00:00:00
abstract：BACKGROUND:We aimed to analyze the association between hypertension and deep vein thrombosis (DVT) after orthopedic surgery. METHODS:Relevant studies were identified by a search of PubMed, Embase, China National Knowledge Infrastructure, Wanfang, the Chinese Biomedical Literature, and Weipu database until December 201...
journal_title：European journal of medical research
pub_type： 杂志文章,meta分析
doi：10.1186/s40001-016-0207-z
更新日期：2016-03-22 00:00:00
abstract：:While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：2003-04-30 00:00:00
abstract：:Echinocandins represent the newest class of antifungal agents. Currently, three echinocandins, anidulafungin, caspofungin and micafungin are licensed for clinical use in various indications. They act as inhibitors of β-(1,3)-glucan synthesis in the fungal cell wall and have a favorable pharmacological profile. They ha...
journal_title：European journal of medical research
pub_type： 杂志文章,评审
doi：10.1186/2047-783x-16-4-159
更新日期：2011-04-28 00:00:00
abstract：:The aim of the study was to investigate whether cholecystokinin, neurotensin, and cholinergic mechanisms act as mediators of bile salt-stimulated exocrine pancreatic secretion. Ten fasting healthy subjects provided with a double-lumen tube received 2, 4, and 6 g cattle bile and 200, 400, and 600 mg Na-taurodeoxycholat...
journal_title：European journal of medical research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
