Abstract:
BACKGROUND:A novel software ("Dynamic Coronary Roadmap") was developed, which offers a real-time, dynamic overlay of the coronary tree on fluoroscopy. Once the roadmap has been automatically generated during angiography it can be used for navigation during percutaneous coronary interventions (PCI). As a feasibility study, we aimed to investigate the feasibility of real-time dynamic coronary roadmapping and consecutive coronary overlay during elective PCI. METHODS AND RESULTS:We studied 936 overlay runs, created following the same amount of angiographies, which were generated during 36 PCIs. Feasibility of dynamic coronary roadmapping was analyzed using a dedicated software tool. Roadmap quality (correct dynamic imaging of the vessels without relevant artefacts or missing parts) was distinguished from overlay quality (congruence of dynamic coronary roadmapping and coronary anatomy). Additionally, we assessed procedural success and the occurrence of major cardiac and cerebrovascular events (MACCE). Roadmap quality was defined as "fit for use" in 99.5%. In 97.4% of runs overlay quality was deemed "fit for use". Overall, we observed low inter and intra observer variability (ICC R = 0.84 for roadmap quality and R = 0.75 for overlay quality). Procedural success rate was 100%. MACCE occurred in two (5.6%) patients during post-interventional in-hospital stay and were not software-related. CONCLUSIONS:Dynamic coronary roadmapping provides in > 98% of cases sufficient roadmap quality with an anatomically correct overlay of the coronary vessels with good inter and intra observer variability. Future randomized studies are warranted to test possible advantages like procedure time reduction and less consumption of contrast medium.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Piayda K,Kleinebrecht L,Afzal S,Bullens R,Ter Horst I,Polzin A,Veulemans V,Dannenberg L,Wimmer AC,Jung C,Bönner F,Kelm M,Hellhammer K,Zeus Tdoi
10.1186/s40001-018-0333-xsubject
Has Abstractpub_date
2018-07-31 00:00:00pages
36issue
1eissn
0949-2321issn
2047-783Xpii
10.1186/s40001-018-0333-xjournal_volume
23pub_type
杂志文章abstract:OBJECTIVE:Evaluating the effects of prophylactic administration of IgM-enriched immunoglobulins (IVIG) on immunological- and clinical parameters in cardiac surgical patients. PATIENTS AND METHODS:41 patients were randomized to receive either an IgM-enriched immunoglobulin (Pentaglobin(R)) preparation (1,300 ml immunog...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-12-17 00:00:00
abstract:OBJECTIVE:Identification of specific origin of lipid accumulation in the liver of patients with non-alcoholic fatty liver disease (NAFLD) is the most important step in preventing this condition. Because liver steatosis, in the obese patients without any systemic disease, can be graded easily by ultrasonography (US), we...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-02-26 00:00:00
abstract:BACKGROUND:Cardiovascular autonomic neuropathy (CAN) is rapidly growing in all populations worldwide. Baroreflex sensitivity (BRS) is easily applied as a diagnostic test to a large number of individuals in the general population. However, no study has reported the normal reference values of BRS for the CAN diagnostic t...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-19-8
更新日期:2014-02-12 00:00:00
abstract::While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2003-04-30 00:00:00
abstract::CMV infection is common in pediatric HIV-1 infected patients. We present a case report, to our knowledge the first pediatric patient, in which Addison-disease due to CMV was suspected during lifetime. We want to point out the importance of routine clinical and laboratory follow up once a HIV-1 infected child is shown ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2000-06-20 00:00:00
abstract:INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2008-11-24 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN:Randomised, double blind, placebo-controlled clinical trial. SETTING:Tertiary university clinic. SUBJECTS...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2006-08-30 00:00:00
abstract:BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-06-28 00:00:00
abstract::A fifty-year-old female presented with a one month history of progressive dyspnea, productive cough, pain of elbows and knees, and 40°C fever despite antibiotic treatment. She has been diagnosed of bronchial asthma over 25 years before admission and oral and depot glucocorticosteroids as a long-term therapy was applie...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-s2-92
更新日期:2010-11-04 00:00:00
abstract:BACKGROUND:During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-03-26 00:00:00
abstract:BACKGROUND:The concept of total mesorectal excision has revolutionised rectal cancer surgery. TME reduces the rate of local recurrence and tumour associated mortality. However, in clinical trials only 50% of the removed rectal tumours have an optimal TME quality. PATIENTS:During a period of 36 months we performed 103 ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-7-292
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Postoperative hyperthyroidism occurs in approximately one third of patients following parathyroidectomy due to primary hyperparathyroidism (PHP), but has only rarely been described in secondary hyperparathyroidism (SHP). The frequency, course, and laboratory markers of postoperative hyperthyroidism in SHP re...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-8-375
更新日期:2011-08-08 00:00:00
abstract::The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of pati...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1996-05-24 00:00:00
abstract::Tooth-colored resin-based restoration materials have gained enormous significance in recent decades. Since the composites presently available still evidence various weaknesses, intensive research continues concerning them. In this study we tested the biocompatibility of six resin-based materials (Charisma, Solitaire, ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1999-04-27 00:00:00
abstract:OBJECTIVE:The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail. METHODS:Human MSCs were isolated and cultivated onto the surface of a 3 x 3 mm porcine collagen I / III carrier. After incubation, cell cultur...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-15-1-35
更新日期:2010-01-29 00:00:00
abstract:BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are sporadic, acute worsening of symptoms. Identifying predictors of exacerbation frequency may facilitate medical interventions that reduce exacerbation frequency and severity. The objective of this study was to determine predictors of exacerbati...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-19-18
更新日期:2014-04-08 00:00:00
abstract:BACKGROUND:Bone fracture is one of the most common physical injuries in which gene expression and the microenvironment are reprogramed to facilitate the recovery process. METHODS:By specific siRNA transfection and MTT assay, we evaluated the effects of metastasis-associated gene 1 (MTA1) in osteoblast growth. To show ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0084-x
更新日期:2015-02-03 00:00:00
abstract::In Germany during the past years about 200-250 HIV infected pregnant women delivered a baby per year, a number that is currently increasing. To determine the HIV-status early in pregnancy voluntary HIV-testing of all pregnant women is recommended in Germany and Austria as part of prenatal care. In those cases, where H...
journal_title:European journal of medical research
pub_type: 共识发展会议,杂志文章,评审
doi:
更新日期:2004-06-30 00:00:00
abstract:BACKGROUND:The current pilot study compares the impact of an intravenous infusion of Ringer's lactate to an acetate-based solution with regard to acid-base balance. The study design included the variables of the Stewart approach and focused on the effective strong ion difference. Because adverse hemodynamic effects hav...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-17-21
更新日期:2012-07-06 00:00:00
abstract:BACKGROUND:Acute lung injury (ALI) is a serious clinical syndrome with a high rate of mortality. In this study, the effects of triptolide on lipopolysaccharide (LPS)-induced ALI in rats were investigated. METHODS:Sixty-five male Sprague Dawley rats(approved by ethics committee of the First Affiliated Hospital of Sooch...
journal_title:European journal of medical research
pub_type: 杂志文章,收录出版
doi:10.1186/2047-783X-18-58
更新日期:2013-12-17 00:00:00
abstract:BACKGROUND:Sonography has become the imaging technique of choice for guiding intraoperative interventions in abdominal surgery. Due to artefacts from residual air content, however, videothoracoscopic and open intraoperative ultrasound-guided thermoablation of lung malignancies are impossible. Lung flooding is a new met...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-23
更新日期:2013-07-10 00:00:00
abstract:UNLABELLED:Prolonged immobilization of severely ill, bed-ridden patients results in formation of pressure ulcers following inappropriate tissue blood perfusion, and local activation of leukocyte - endothelial cell interactions (L/EC). Various treatment modalities were implemented to improve local microcirculation with ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-04-20 00:00:00
abstract:INTRODUCTION:Recombinant human growth hormone (r-hGH) has demonstrated efficacy in treating HIV-associated wasting (HAW), however, HAW has become less prominent since the introduction of highly active antiretroviral therapy (HAART). Recent studies suggest that patients receiving HAART may still experience HAW. We inves...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2002-03-28 00:00:00
abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-08-17 00:00:00
abstract::Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-10-433
更新日期:2009-09-28 00:00:00
abstract:BACKGROUND:In pursuit of improvement in cardiopulmonary resuscitation (CPR), new technologies for the measurement and assessment of CPR quality are implemented. In our study, we assessed the kinematics of the rescuer during continuous chest compression (CCC-CPR). The proper performance of the procedure is a survival pr...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-019-0369-6
更新日期:2019-02-08 00:00:00
abstract:OBJECTIVE:The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). METHODS:Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF,...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0194-5
更新日期:2016-01-08 00:00:00
abstract::We investigated the hypothesis that religious commitment could help counter general affective distress, accompanying depressive symptoms, in older age. A total of 34 older adults, all catholic believers, completed self-reported questionnaires on the presence of depressive symptoms, religiosity, health, worry, and the ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-16-9-401
更新日期:2011-09-12 00:00:00
abstract:BACKGROUND:Fingertip injuries treated with occlusive dressings (ODs) lead to nearly scar-free, functionally, and aesthetically pleasing results. We hypothesized that paracrine factors in the wound fluid (secretome) may influence migration and proliferation of mesenchymal stem cells (MSCs) and fibroblasts and modulate t...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-018-0357-2
更新日期:2018-12-26 00:00:00
abstract:BACKGROUND:The purpose was to explore possible risk factors of facet joint violation induced by adjacent superior vertebral pedicle screw during the minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF). METHODS:A total of 69 patients with lumbar degenerative disease, who underwent MIS-TLIF were...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0174-9
更新日期:2015-09-24 00:00:00