Abstract:
BACKGROUND/OBJECTIVE:The continuous interaction of blood with artificial contact surfaces under cardiopulmonary bypass can lead to a substantial damage of blood cells and plasma factors. Surface biopolymers in oxygenation systems can help increasing the hemocompatibility, often combined with anticoagulative agents such as heparin. The poly(2-methoxyethylacrylate) [PMEA] is a new heparin-free polymer. The objective of this experimental study was to evaluate the hemocompatibility of a PMEA-coated oxygenator (Terumo Capiox RX-25) (PTX) under standardized in vitro conditions compared to two ionic-bound and one covalent-bound heparin-coated models. METHOD:Each oxygenator was mounted in a separate standardized closed circulation system. Heparinized (5 IE/mL) fresh human blood from the same donor (hemodilution: Ringer's solution) was used. Circulation time: 120 - 180 min with a flow rate of 4.0 L/min. Blood samplings: at the beginning, 5. min and every 30 min of the circulation. PARAMETERS:platelets, granulocytes, plasma factors (p-selectin, alpha-granulomeres expression, and TAT(III)-complex). After the experiment, oxygenators were dismantled and examined by scanning electron microscopy. RESULTS:All of the oxygenators led to an initial reduction of platelets and granulocytes. PTX had the lowest platelet and granulocyte reduction rates. With a lower p-selectin release compared to covalent-bound heparin-coated oxygenator and higher expression of alpha-granulomeres compared to ionic-bound heparin-coated oxygenators, the results of PTX indicated that a high number of circulating platelets were intact on the PMEA surface. TAT(III)-complex showed a steady increase in all of the oxygenators during the tests, more remarkably in PTX. In contrast to ionic-bound heparin-coated oxygenators, the electron microscopy displayed virtually no cellular accumulation on hollow fiber and housing surfaces of PTX and covalent-bound heparin-coated oxygenator. CONCLUSIONS:1. The hemocompatibility characteristics of PTX were remarkably better than ionic-bound heparin-coated oxygenators and slightly better than the covalent-bound heparin-coated model under in vitro conditions. 2. The PMEA coating can be a useful alternative for patients with heparin-associated disorders. 3. The clinical feasibility of PTX should be evaluated under in vivo conditions.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Baykut D,Bernet F,Wehrle J,Weichelt K,Schwartz P,Zerkowski HRsubject
Has Abstractpub_date
2001-07-30 00:00:00pages
297-305issue
7eissn
0949-2321issn
2047-783Xjournal_volume
6pub_type
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-9-413
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 共识发展会议,杂志文章,评审
doi:
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-014-0074-4
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journal_title:European journal of medical research
pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-019-0365-x
更新日期:2019-01-28 00:00:00