Abstract:
OBJECTIVE:Evaluating the effects of prophylactic administration of IgM-enriched immunoglobulins (IVIG) on immunological- and clinical parameters in cardiac surgical patients. PATIENTS AND METHODS:41 patients were randomized to receive either an IgM-enriched immunoglobulin (Pentaglobin(R)) preparation (1,300 ml immunoglobulin, equivalent to 65 g protein) combined with routine antibiotic prophylaxis (Group A; n = 20, 1 drop-out), or routine antibiotic prophylaxis plus placebo (Group B; n = 20). Patients were comparable with respect to their APACHE II score, comorbidity, coronary risk, operating time, clamp, and ischemic time. Endotoxin and endotoxin neutralizing capacity (ENC) were determined by a kinetic turbidimetric Limulus amebocyte lysate (LAL) assay with internal standardization. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF)-alpha, soluble TNF-Receptor I (sTNF-R1), and interleukin-10 (IL-10) were determined by ELISA. Data analysis was performed by area under the curve (AUC) calculation and ANOVA for endotoxin neutralizing capacity and by ANOVA for all other cases. RESULTS:All patients survived. Endotoxin plasma levels were generally but not significantly higher in group A than in controls, while the difference in endotoxin neutralizing capacity (ENC) reached significance. IL-6, TNF-alpha, IL-10 and TNF-R1 were not different between both groups, however. There were significantly less patients with signs of inflammation (fever, leukocytosis, hypotension) in group A (group A n = 2; group B n = 9; p<0.05). This was paralleled by a slightly reduced hospitalization period in group A patients compared to group B patients (A:12.05 +/- 3.66 vs. B:13.45 +/- 3.72 days; n.s.). All data are given as mean +/- standard deviation (SD). CONCLUSION:The results of this study support that IgM-enriched IVIG preparation are effective when used prophylactically in patients undergoing procedures with cardiopulmonary bypass. The mechanisms of endotoxin neutralization and the effect of the host immune status on the efficacy of IVIG treatment remain to be elucidated.
journal_name
Eur J Med Resjournal_title
European journal of medical researchauthors
Friedrich I,Silber RE,Baumann B,Fischer C,Holzheimer RGsubject
Has Abstractpub_date
2002-12-17 00:00:00pages
544-9issue
12eissn
0949-2321issn
2047-783Xjournal_volume
7pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:To compare the effect of totally thoracoscopic with conventional, open repair of atrial septal defect. METHODS:Forty atrial septal defect cases were divided into two groups by surgical approach: totally thoracoscopic approach (group A, n = 20) and conventional open approach (group B, n = 20). In group A, su...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:10.1186/2047-783X-19-13
更新日期:2014-03-11 00:00:00
abstract::Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer sur...
journal_title:European journal of medical research
pub_type: 社论
doi:10.1186/s40001-018-0359-0
更新日期:2019-01-03 00:00:00
abstract:OBJECTIVE:Efavirenz (EFV) plasma levels have been discussed as a predictor of treatment failure in HIV infected patients. The aim of this prospective, open-labeled, case-control study was to evaluate pretreated patients in regards to efavirenz plasma levels and efficacy of therapy. METHODS:Blood samples were obtained ...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-07-24 00:00:00
abstract::Among primary hepatic malignancies, sarcomas represent a minority of 2 %. Of those, primary hepatic angiosarcoma is the most common one. In the past its incidence has been related to the exposure of certain chemicals like thorotrast, vinyl-chloride or arsenic. - Patients suffering from this aggressive, highly vascular...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-12-14 00:00:00
abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-08-17 00:00:00
abstract:INTRODUCTION:In utero and/or childhood environmental tobacco smoke exposure is well known to adversely affect lung function and to depreciate child's health in many ways. Fewer studies have assessed the long-term effects on COPD development and disease severity in later adulthood. METHODS:COPD patients were interviewe...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-s4-27
更新日期:2009-12-07 00:00:00
abstract::Determination of fecal excretion of the serum proteinase inhibitor alpha(1)-antitrypsin (AAT) is established for quantification of intestinal protein loss. It was demonstrated to be increased both in quiescent and in active inflammatory bowel diseases (IBD, Crohn's disease and ulcerative colitis). The (patho)physiolog...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1998-02-21 00:00:00
abstract:OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...
journal_title:European journal of medical research
pub_type: 杂志文章,多中心研究
doi:10.1186/2047-783x-14-4-171
更新日期:2009-04-16 00:00:00
abstract::The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity. Expression of Gbeta3s, the gene product of GNB3 associated with the GNB3 825T-allele, causes increased signal transduction which may contribute to pat...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2003-03-27 00:00:00
abstract::More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...
journal_title:European journal of medical research
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-20 00:00:00
abstract::In ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1997-10-30 00:00:00
abstract:BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant tumor syndrome predisposing to predominantly colorectal and endometrial cancer. In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MS...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2005-01-28 00:00:00
abstract::Photoplethysmography enables non-invasive investigation of the volume pulse in the microvasculature of patients. We previously have shown that time-discrete analysis enables identification of highly reproducible characteristics of the volume pulse in absolute values. The method would be of particular interest, if the ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:1998-05-12 00:00:00
abstract:BACKGROUND:During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2007-03-26 00:00:00
abstract:BACKGROUND:Melasma is a common hypermelanosis of the face. The use of a classical Q-switched ruby laser (QSRL) to treat melasma is discussed controversially and is associated with frequent adverse effects, such as hyper- or hypopigmentation. Recently a fractional-mode (FRx) QSRL was developed to minimize the adverse ef...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-43
更新日期:2013-11-14 00:00:00
abstract::Possible effects of electromagnetic fields on human brain activity were studied. In a single-blind, cross-over-designed and placebo-controlled study 36 volunteers were exposed firstly to an electromagnetic field originating form a MediLine "MEGA-WAVE 150/1" therapy instrument and secondly to a field originating from a...
journal_title:European journal of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-10-16 00:00:00
abstract:BACKGROUND:Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure and thereby entails higher morbidity and mortality in trauma patients. Pro- and anti-inflammator...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-7-284
更新日期:2009-07-22 00:00:00
abstract:BACKGROUND:Since the new 2009 guidelines for left subclavian artery (LSA) management using thoracic endovascular aortic repair (TEVAR), a few studies have been published about alternative LSA management. The objective of this study was to present the follow-up results of covered or revascularized LSA during TEVAR. MET...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-015-0147-z
更新日期:2015-05-31 00:00:00
abstract:UNLABELLED:Prolonged immobilization of severely ill, bed-ridden patients results in formation of pressure ulcers following inappropriate tissue blood perfusion, and local activation of leukocyte - endothelial cell interactions (L/EC). Various treatment modalities were implemented to improve local microcirculation with ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-04-20 00:00:00
abstract::The immunological environment of leukemic blasts in the bone marrow might play a decisive role in determining an individual's risk for relapse. In order to identify potential predictors of relapse and to elucidate the mechanisms of immune control of leukemic blasts we examined the expression of cytokines, costimulator...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2006-03-27 00:00:00
abstract::Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783x-14-10-433
更新日期:2009-09-28 00:00:00
abstract::While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2003-04-30 00:00:00
abstract:BACKGROUND:The expression of heparanase (HPSE) was associated with postoperative metastatic recurrence in patients with hepatocellular carcinoma (HCC). The six E-box binding sites in the core promoter of the HPSE gene suggested that transcription factors of E-box such as upstream stimulatory factor (USF) might regulate...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-014-0045-9
更新日期:2014-08-23 00:00:00
abstract:BACKGROUND:Osteoporosis affects 200 million people worldwide and places an enormous economic burden on society. We aim to identify the feature genes that are related to osteoprotegerin in osteoporosis and to perform function analysis with DNA microarray from human bone marrow. METHODS:We downloaded the gene expression...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-18-15
更新日期:2013-06-03 00:00:00
abstract:BACKGROUND:Sepsis leads to severe inflammatory and cardiac dysfunction. This study aimed to explore the clinical value of miR-495 in sepsis, as well as its role in sepsis-induced inflammation and cardiac dysfunction. METHODS:105 sepsis patients were recruited; receiver operating characteristic (ROC) curve was plotted ...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-019-0396-3
更新日期:2019-11-26 00:00:00
abstract:BACKGROUND:Resternotomy in cardiac surgery is considered a risk factor for postoperative complications. Previous studies have demonstrated an ambiguous relationship between resternotomy and clinical outcomes. Registry data from a mixed population of durable circulatory support devices suggest that history of cardiac su...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-017-0289-2
更新日期:2017-11-15 00:00:00
abstract:BACKGROUND:Cardiovascular autonomic neuropathy (CAN) is rapidly growing in all populations worldwide. Baroreflex sensitivity (BRS) is easily applied as a diagnostic test to a large number of individuals in the general population. However, no study has reported the normal reference values of BRS for the CAN diagnostic t...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-19-8
更新日期:2014-02-12 00:00:00
abstract:BACKGROUND:The Orthogonal Polarization Spectral (OPS) imaging technique has been introduced for in vivo assessment of microcirculation in humans. Unclear remains, whether the new technique would allow for accurate investigations of the colon microcirculation with respect to the unique conditions of the microvasculature...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:
更新日期:2001-12-17 00:00:00
abstract:BACKGROUND:Current evidence regarding the prognostic relevance of urinary sodium-to-potassium ratio (Na-to-K ratio), as an indicator of diet quality is limited. This study was conducted to investigate whether urinary Na-to-K ratio could be related to habitual dietary patterns, in a general population. METHODS:This stu...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/s40001-020-00476-5
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:The current pilot study compares the impact of an intravenous infusion of Ringer's lactate to an acetate-based solution with regard to acid-base balance. The study design included the variables of the Stewart approach and focused on the effective strong ion difference. Because adverse hemodynamic effects hav...
journal_title:European journal of medical research
pub_type: 杂志文章
doi:10.1186/2047-783X-17-21
更新日期:2012-07-06 00:00:00